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61,005 resultsShowing papers similar to Multivariate Analysis of Protein–Nanoparticle Binding Data Reveals a Selective Effect of Nanoparticle Material on the Formation of Soft Corona
ClearAn integrative method for evaluating the biological effects of nanoparticle-protein corona.
Researchers developed an integrative method combining dynamic light scattering, transmission electron microscopy, and cellular assays to evaluate how protein corona formation on nanoplastic surfaces alters their biological interactions, finding that corona composition significantly changes cellular uptake pathways and cytotoxicity profiles.
Structure of soft and hard protein corona around polystyrene nanoplastics—Particle size and protein types
Researchers characterized the protein corona that forms around polystyrene nanoplastics of different sizes, finding that particle size influences which proteins bind and how tightly, with implications for nanoplastic toxicity and biological uptake.
Assessment on interactive prospectives of nanoplastics with plasma proteins and the toxicological impacts of virgin, coronated and environmentally released-nanoplastics
Researchers found that nanoplastics quickly coat themselves in blood proteins, forming a multi-layered "corona" that changes the proteins' shape and makes them biologically harmful; these protein-coated nanoplastics caused more DNA and cell damage in human blood cells than bare nanoplastics. The study highlights the need to regulate nanoplastics in medical products and better understand how they accumulate in the body.
Uptake of extracellular vesicles into immune cells is enhanced by the protein corona
This study found that a protein coating (called a "corona") that forms around nanoparticles in blood actually increases their uptake by human immune cells called monocytes. While this research focused on extracellular vesicles and liposomes rather than plastic particles, the finding is relevant to microplastics research because similar protein coronas form on plastic nanoparticles in the body, potentially influencing how immune cells interact with them.
Protein at liquid solid interfaces: Toward a new paradigm to change the approach to design hybrid protein/solid-state materials
Researchers review protein adsorption behavior at solid-liquid interfaces, proposing a new classification of proteins as "hard" or "soft" based on their structural stability upon adsorption, which helps predict how proteins form coronas on nanoparticle and material surfaces — a key consideration for nanoplastic-protein interactions in biological environments.
Protein–Nanoparticle Interaction: Corona Formation and Conformational Changes in Proteins on Nanoparticles
This review examines how proteins adsorb onto the surfaces of nanoparticles to form a protein corona, which significantly alters the particles' biological behavior and functionality. Researchers describe how the corona can cause conformational changes in proteins that lead to unexpected immune responses, altered cellular uptake, and changes in toxicity. The findings are relevant to understanding how nanoplastics interact with biological systems, since protein corona formation is a key factor governing their environmental and health effects.
Strong binding between nanoplastic and bacterial proteins facilitates protein corona formation and reduces nanoplastics toxicity
Researchers demonstrated that bacteria-derived proteins adsorb strongly onto nanoplastic surfaces to form a 'protein corona,' altering nanoplastic morphology and reducing their toxicity to bacterial cells — with the degree of protection varying by surface chemistry, as amino-modified nanoplastics showed the greatest reduction in oxidative damage after corona formation.
The Challenges and Opportunities of Protein Coronas for Nanoscale Biomolecular Sensing
Researchers reviewed how protein layers that naturally form around nanoscale objects in biological fluids affect the performance of tiny biosensors. They found that this protein coating can block sensors from detecting target molecules, but new strategies are emerging to work around or even take advantage of this effect. The study is relevant to understanding how nanoplastics behave in the body, since similar protein layers form around plastic nanoparticles and influence their biological interactions.
Artificial engineering of the protein corona at bio-nano interfaces for improved cancer-targeted nanotherapy
Researchers reviewed how engineering the protein corona — the layer of proteins that coats nanoparticles in biological fluids — through modifications like PEGylation and protein pre-coating can improve nanoparticle targeting for cancer drug delivery by controlling how immune cells recognize and clear the particles.
The crucial role of a protein corona in determining the aggregation kinetics and colloidal stability of polystyrene nanoplastics
Time-resolved dynamic light scattering was used to study how protein coronas — protein layers that form on nanoplastics in biological or environmental fluids — control the aggregation kinetics and colloidal stability of polystyrene nanoplastics. Protein identity and concentration profoundly shifted nanoplastic behavior, with implications for how these particles move and persist in natural water systems.
Impact of Protein Corona Formation and Polystyrene Nanoparticle Functionalisation on the Interaction with Dynamic Biomimetic Membranes Comprising of Integrin
Researchers studied how polystyrene nanoparticles interact with blood proteins and cell membranes to understand potential health effects of nanoplastic exposure. They found that when blood proteins coat the nanoparticles, forming a so-called protein corona, it actually reduces the particles' ability to damage cell membranes. The study suggests that the body's natural protein coating of nanoplastics may offer some protection against membrane disruption, though the long-term implications remain unclear.
The protein corona from nanomedicine to environmental science
Researchers reviewed the state of protein corona research — the spontaneous coating of proteins onto nanoparticle surfaces in biological environments — highlighting how artificial intelligence could accelerate the field and how mechanistic insights could improve both nanomedicine therapeutics and environmental safety assessments.
Soft and Hard Interactions between Polystyrene Nanoplastics and Human Serum Albumin Protein Corona
The structure of protein coronas formed when polystyrene nanoplastics interact with human serum albumin (HSA) was analyzed, finding that nanoplastic size and pH influenced whether hard (irreversible) or soft (exchangeable) corona formed, with weak but size-dependent interactions occurring despite the overall low affinity. The study provides mechanistic insight into how nanoplastics may interact with blood proteins upon entering the human circulatory system.
Unravelling protein corona formation on pristine and leached microplastics
Researchers found that when microplastics encounter proteins in biological fluids, they get coated in a "protein corona" that depends heavily on the plastic's chemical additives, surface area, and how much it has been weathered in the environment. This coating changes how microplastics behave in the body, meaning toxicity studies need to account for these real-world surface changes.
Nanoplastics and Protein Corona - Investigating the Corona Structure and their Biological Impacts
This PhD thesis investigated how proteins from biological fluids coat the surface of nanoplastics, forming a 'protein corona' that changes how nanoplastics interact with cells and tissues. The protein corona is important because it alters the biological behavior of nanoplastics once they enter the body, potentially affecting how harmful they are.
Environmental dimensions of the protein corona
Researchers reviewed how nanomaterials entering natural environments acquire an "eco-corona" — a coating of proteins and other biomolecules that alters how organisms recognize and interact with the particles — and called for targeted research into how this coating changes during food chain transfer and affects ecotoxicity.
Essential protocols for decoding the composition and the functional effects of the nanoparticle protein corona
This review provides updated methodological guidance for studying nanoparticle protein coronas — the host protein layers that form around nanoparticles — including shot-gun proteomics, in-gel digestion, and TMT proteomics approaches relevant to medical and pharmacological nanoparticle development.
Surface hydrophobicity and rigidity determines protein corona on orally delivered nanoparticles treating colitis
Researchers showed that surface hydrophobicity and rigidity of orally delivered nanoparticles determine the composition of the colitis-specific intestinal protein corona, with high-rigidity, high-hydrophobicity particles attracting more macrophage-targeting proteins and achieving superior therapeutic outcomes in a rat colitis model.
Thermodynamic Analysis of Protein-Nanoparticle Interactions Links Binding Affinity and Structural Stability
Researchers examined how protein charge distribution influences adsorption onto polystyrene nanoparticles by engineering a series of lysozyme variants and analyzing binding affinity through thermodynamic analysis. They found that electrostatic properties of proteins strongly govern corona formation kinetics and structural stability when nanoplastics enter biological fluids.
Combining confocal microscopy, dSTORM, and mass spectroscopy to unveil the evolution of the protein corona associated with nanostructured lipid carriers during blood–brain barrier crossing
Confocal microscopy, dSTORM, and mass spectrometry were combined to track how the protein corona on nanostructured lipid carriers evolved during blood-brain barrier crossing, finding that corona composition changed dynamically and influenced nanoparticle stability and cell targeting.
Exploring the interactions between protein coronated CdSe quantum dots and nanoplastics
Researchers investigated how protein coatings (coronas) that form on quantum dot nanoparticles affect their interactions with nanoplastics in the environment. These particle-particle interactions can alter how both quantum dots and nanoplastics behave, move, and accumulate in biological systems.
Unravelling protein corona formation on pristine and leached microplastics
When microplastics enter biological fluids or protein-rich environments, proteins coat their surface to form a 'protein corona' that changes how the particles behave in living systems. This study explored how the physical and chemical properties of pristine versus weathered microplastics influence corona formation, finding that surface changes caused by environmental aging significantly alter protein binding. Understanding this process matters because the protein coat — not the plastic itself — is often what cells and organisms first encounter.
Aquatic organisms modulate the bioreactivity of engineered nanoparticles: focus on biomolecular corona
This review examines how aquatic organisms influence the bioreactivity of engineered nanoparticles through the formation of a biomolecular corona in environmental settings. Researchers found that biological molecules shed by organisms can coat nanoparticle surfaces and significantly alter their behavior, toxicity, and fate in aquatic ecosystems beyond what standard laboratory toxicity studies capture.
Protein corona alleviates adverse biological effects of nanoplastics in breast cancer cells
Scientists discovered that when nanoplastics enter human blood, proteins naturally coat their surface forming a "protein corona," and this coating actually reduces some of the harmful effects of the plastics on breast cancer cells. Without the protein coating, nanoplastics stuck to cell membranes and disrupted important signaling pathways, but coated particles were safely captured inside cellular compartments. This finding suggests that the body may have some natural defense against nanoplastics in the bloodstream, though the long-term effects of this process remain unknown.