We can't find the internet
Attempting to reconnect
Something went wrong!
Hang in there while we get back on track
Papers
61,005 resultsShowing papers similar to Screening for subvisible particles in pharmaceutical formulations – a case study
ClearMicroplastics’ Shape and Morphology Analysis in the Presence of Natural Organic Matter Using Flow Imaging Microscopy
Researchers introduced an innovative flow imaging microscopy approach for rapidly identifying and quantifying microplastics in wastewater treatment plant samples. The study demonstrates that this method can simultaneously capture and classify polyethylene and polystyrene particles while also analyzing how natural organic matter affects microplastic shape and morphology.
Micro-plastics as a source of contaminaion in pharmaceuticals
This review examined how microplastics contaminate pharmaceutical manufacturing environments and products, discussing the potential health risks of plastic particle exposure through medicines and the pathways by which microplastics enter pharmaceutical supply chains.
Evaluation of Ceramic Membrane Filtration for Alternatives to Microplastics in Cosmetic Formulations Using FlowCam Analysis
Ceramic membrane crossflow filtration was evaluated for removing silica powder and cornstarch—common microplastic alternatives in cosmetics—with FlowCam particle analysis revealing high removal efficiency and insights into particle behavior that can guide greener cosmetic formulation strategies.
Morphologically-Directed Raman Spectroscopy as an Analytical Method for Subvisible Particle Characterization in Therapeutic Protein Product Quality
Researchers tested a method called Morphologically-Directed Raman Spectroscopy (MDRS) to identify and chemically characterize tiny particles in injectable drug products, successfully identifying over 90% of particles between 19 and 100 micrometers. This technique could improve quality control for pharmaceuticals and has parallels to methods used to identify microplastic particles in environmental samples.
A Comparison of Different Approaches for Characterizing Microplastics in Selected Personal Care Products
Researchers compared particle size analysis, light microscopy, and imaging flow cytometry combined with micro-FTIR spectroscopy for characterizing microplastics in personal care products, finding that methodology choice significantly affects quantification results and highlighting the need for standardized approaches.
Determination of the pharmaceuticals–nano/microplastics in aquatic systems by analytical and instrumental methods
Researchers reviewed analytical and instrumental methods for detecting pharmaceutical compounds associated with nano- and microplastic particles in aquatic systems. They examined how pharmaceuticals bind to plastic particles and the combined environmental risks these mixtures pose to water sources and marine life. The study identifies gaps in current detection capabilities and calls for improved methods to assess the combined impact of these co-occurring pollutants.
Flow cytometry as new promising detection tool for micro and submicron plastic particles
Researchers evaluated flow cytometry as a tool for detecting and counting micro- and submicron plastic particles in environmental and biological samples. The method offered rapid throughput and the ability to distinguish plastic particles from biological material, but required careful optimization for complex matrices.
Flow cytometry as new promising detection tool for micro and submicron plastic particles
Researchers evaluated flow cytometry as a detection tool for micro- and nanoplastics, testing its ability to rapidly identify and count plastic particles in environmental and biological samples. Results demonstrated that flow cytometry offers a promising high-throughput approach for microplastic detection compared to more time-intensive conventional methods.
The micro-, submicron-, and nanoplastic hunt: A review of detection methods for plastic particles
This review systematically summarizes detection and characterization methods for micro-, submicron-, and nanoplastics, providing recommendations for method validation, standardization, and analytical pathways suited to different sample types and research goals.
Challenges in Determining the Size Distribution of Nanoparticles in Consumer Products by Asymmetric Flow Field-Flow Fractionation Coupled to Inductively Coupled Plasma-Mass Spectrometry: The Example of Al2O3, TiO2, and SiO2 Nanoparticles in Toothpaste
This study developed a method for determining the size of nanoparticles in consumer products like toothpaste using asymmetric flow field-flow fractionation coupled to mass spectrometry. The methodology has direct relevance to detecting and characterizing nanoplastic particles in personal care products and other consumer goods.
From qualitative to quantitative measurement of small microplastics using multi-detector field flow fractionation coupled offline to microscopy and raman spectroscopy
This study developed an analytical method combining multi-detector field flow fractionation with offline microscopy and Raman spectroscopy to move from simply identifying microplastics to accurately measuring their quantity in small size ranges. Improved quantification methods are critical because current inconsistencies in measurement approaches make it difficult to set health-based exposure limits or compare contamination levels across studies.
From qualitative to quantitative measurement of small microplastics using multi-detector field flow fractionation coupled offline to microscopy and raman spectroscopy
This study developed an analytical method combining multi-detector field flow fractionation with offline microscopy and Raman spectroscopy to move from simply identifying microplastics to accurately measuring their quantity in small size ranges. Improved quantification methods are critical because current inconsistencies in measurement approaches make it difficult to set health-based exposure limits or compare contamination levels across studies.
Spectro‐Microscopic Techniques for Studying Nanoplastics in the Environment and in Organisms
This review examines spectro-microscopic techniques for detecting and characterizing nanoplastics (under 1 um) in environmental and biological matrices, arguing that effective analysis requires combining particle imaging with chemical characterization of the same particles, and highlighting methods capable of simultaneous morphological and chemical identification.
In-flow single particle detection of sub-100 micron microplastics
Researchers developed an in-flow single particle detection method for identifying microplastics smaller than 100 microns. The study addresses the particular concern around sub-100 micron microplastics, which are more likely to be ingested by organisms and are harder to detect using conventional methods.
Impact of Microplastic Contaminants on Drug Stability and Safety
Researchers reviewed how microplastic contaminants may alter the stability, bioavailability, and safety of pharmaceutical products by adsorbing drug compounds and releasing them unpredictably. Survey data from pharmaceutical quality assurance professionals and literature synthesis identified specific mechanisms by which MPs could degrade drug formulations, flagging an underexplored drug safety concern.
Matrix Overloading Effects on Size-Resolved Quantification of Low-Concentration Nanoplastics in Complex Environmental Matrices Using Asymmetric Flow Field-Flow Fractionation
Researchers developed a size-resolved method for quantifying nanoplastics in the 20-200 nm range in environmental water samples using asymmetric flow field-flow fractionation. The study identified important analytical artifacts from matrix overloading effects that can occur when measuring low-concentration nanoplastics in complex environmental samples, providing guidance for more accurate quantification methods.
Pharmaceuticals and micro(nano)plastics in the environment: Sorption and analytical challenges
This review examines how pharmaceutical residues and micro- and nanoplastics interact in water environments, finding that microplastics can adsorb medications and alter their environmental behavior. Factors like plastic type, surface area, and biological film growth all influence these interactions, but very few studies have been conducted under real-world conditions. The authors highlight persistent analytical challenges and the need for field-based research to understand actual risks.
Novel methodology for identification and quantification of microplastics in biological samples
Researchers validated a protocol for identifying and quantifying polyethylene microplastics in biological samples, finding that membrane filtration caused particle retention problems and that flow cytometry offered a more reliable alternative for analysis of biological digests.
Physicochemical characterization and quantification of nanoplastics: applicability, limitations and complementarity of batch and fractionation methods
Researchers evaluated a suite of techniques for measuring the size, shape, and chemical makeup of nanoplastics — plastic particles smaller than 1 micrometer — and found that no single method works for all sample types, especially when particles vary in size or clump together. Combining multiple complementary techniques is essential for reliable nanoplastic characterization, particularly in complex environmental or biological samples.
Flow Raman Spectroscopy for the Detection and Identification of Small Microplastics
Researchers developed a new method using flow Raman spectroscopy to detect and identify individual microplastic particles as small as 4 micrometers while they move through water. Unlike current methods that require complex sample preparation, this technique could work in real time for monitoring food and drinking water quality. The method can distinguish between different plastic types even after they have been weathered by the environment.
Matrix OverloadingEffects on Size-Resolved Quantificationof Low-Concentration Nanoplastics in Complex Environmental MatricesUsing Asymmetric Flow Field-Flow Fractionation
Researchers developed a size-resolved nanoplastic quantification method using asymmetric flow field-flow fractionation with on-channel preconcentration, identifying and characterizing matrix overloading effects that cause analytical artifacts when measuring nanoplastics in complex environmental water samples.
Finding the tiny plastic needle in the haystack: how field flow fractionation can help to analyze nanoplastics in food
This review assessed field flow fractionation (FFF) as an analytical method for detecting and characterizing nanoplastics in food, noting that conventional techniques lack the resolution to identify nano-sized plastic particles in complex food matrices. FFF was identified as a promising tool for generating the exposure data needed for nanoplastic risk assessment.
Micro(nano)plastics as a vector of pharmaceuticals in aquatic ecosystem: Historical review and future trends
This systematic review examines how microplastics and nanoplastics in water can absorb and carry pharmaceutical drugs, creating a combined pollution threat. When medications attach to tiny plastic particles in rivers and oceans, they may become more harmful to aquatic life and potentially to humans who consume contaminated seafood or water. The research traces how this emerging double-threat has grown since 2018 and identifies key knowledge gaps.
A promising method for fast identification of microplastic particles in environmental samples: A pilot study using fluorescence lifetime imaging microscopy
Researchers piloted fluorescence lifetime imaging microscopy as a fast method for identifying microplastic particles in environmental samples. The study suggests this technique could simplify microplastic analysis by potentially eliminating the need for extensive extraction steps, enabling more direct identification of plastic particles in complex matrices.