Papers

20 results
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Article Tier 2

Advancements in Assays for Micro- and Nanoplastic Detection: Paving the Way for Biomonitoring and Exposomics Studies

This review surveys the latest methods for detecting micro and nanoplastics in human tissues and bodily fluids, including blood, breast milk, stool, and lung tissue. Current detection techniques have significant limitations in sensitivity and standardization, making it difficult to accurately measure how much plastic is in people's bodies. Developing better, scalable detection methods is essential for understanding the true extent of human microplastic exposure and its health consequences.

2024 The Annual Review of Pharmacology and Toxicology 18 citations
Article Tier 2

Effects of Microplastics on the Human Body and Methods of Detection

This review summarized how microplastics and nanoplastics enter the human body through ingestion, inhalation, and skin contact, and outlined current detection methods used to identify them in biological samples. The authors found that while evidence of tissue accumulation is growing, health effect thresholds and standardized exposure metrics are still lacking.

2025 Korea Industrial Technology Convergence Society
Article Tier 2

Microplastics: challenges of assessment in biological samples and their implication for in vitro and in vivo effects

This review covers how microplastics enter the human body through ingestion and inhalation, the challenges of detecting and measuring them in biological samples, and the evidence for harmful effects ranging from inflammation to hormonal disruption. Standardising methods for measuring microplastics in tissues and bodily fluids is a key obstacle to advancing human health research. The review provides a useful framework for understanding what we know and what still needs to be established about microplastic risks to people.

2023 Research Square (Research Square)
Article Tier 2

Detection of nano- and microplastics in mammalian tissue

This review examined methods for detecting nano- and microplastics in mammalian tissue, surveying analytical approaches as concerns grow about accumulation in biological systems. The paper discussed how continuous fragmentation and environmental accumulation are increasing the likelihood of tissue uptake across multiple organ systems.

2024 Zenodo (CERN European Organization for Nuclear Research)
Article Tier 2

Microplastics: challenges of assessment in biological samples and their implication for in vitro and in vivo effects

This review examines the challenges of detecting and assessing microplastics in biological samples, noting that analytical limitations and lack of standardized methods hinder our understanding of health effects. The study highlights that humans are exposed to microplastics primarily through ingestion and inhalation, and that more long-term studies with standardized protocols are needed to understand the full scope of potential biological impacts.

2023 Environmental Science and Pollution Research 7 citations
Systematic Review Tier 1

Microplastics and Nanoplastics in human tissues: Systematic review of evidence, analytical protocols, and methodological challenges

This systematic review pulls together evidence on microplastics and nanoplastics found in human tissues like lungs, liver, and placenta. It confirms that tiny plastic particles are accumulating in our bodies, though detection methods still vary widely between studies, making it hard to compare results.

2026 Talanta Open
Article Tier 2

Morphological and chemical characterization of nanoplastics in human tissue

Researchers developed methods to visualize and chemically characterize nanoplastics that have accumulated in human tissue samples. They were able to identify plastic particles smaller than one micrometer within tissue using advanced microscopy and spectroscopy techniques. The study provides some of the first direct evidence of nanoscale plastic accumulation in the human body, which is essential for designing future health effects research.

2025 2 citations
Article Tier 2

Separation and Detection of Microplastics in Human Exposure Pathways: Challenges, Analytical Techniques, and Emerging Solutions

This review examines the challenges of detecting and measuring microplastics in human tissues and body fluids, where they have been confirmed to exist. Current methods struggle with very small particles (nanoplastics) and lack standardized procedures, making it hard to accurately assess how much plastic is in our bodies. The authors highlight promising new technologies like microfluidic systems and AI-assisted analysis that could improve our ability to measure human exposure.

2025 Journal of Xenobiotics 5 citations
Article Tier 2

Microplastics, an Emerging Concern: A Review of Analytical Techniques for Detecting and Quantifying Microplatics

This review surveyed analytical methods for detecting and quantifying microplastics published from 2000 to 2018, covering visual identification, spectroscopic, and pyrolysis-based techniques across environmental, food, and biological matrices. The authors identify the lack of standardized methods as a major barrier to generating comparable data on microplastic prevalence and health implications.

2019 Analytical Methods in Environmental Chemistry Journal 82 citations
Article Tier 2

Microplastic Exposure and Human Health: Advancing Risk Assessment and Future Research Directions

This review synthesizes recent evidence that microplastics are present in human blood, respiratory tissue, placenta, and gut, examines proposed toxicological mechanisms, and identifies priorities for improving risk assessment frameworks and exposure measurement methods.

2025 Theoretical and Natural Science
Article Tier 2

Microplastic Identification and Quantification in Biological Samples

This review examines methods for identifying and quantifying microplastics in biological samples, noting the urgent need for standardized protocols as plastic particles accumulate in marine, terrestrial, and human environments. The paper discusses human exposure routes through ingestion, inhalation, and dermal contact, and highlights gaps in understanding microplastic effects on coagulation and other biological processes.

2024 Proceedings of IMPRS
Article Tier 2

Microplastics in Humans: A Critical Review of Biomonitoring Evidence and Immune–Metabolic Associations

This review critically evaluates the current evidence on microplastic detection in human tissues and biological fluids, focusing on methodological challenges and the potential biological mechanisms of action. Researchers found significant variation across studies due to differences in analytical techniques and sample handling protocols. The study highlights emerging evidence linking microplastic presence in the body to immune and metabolic disruptions, while noting that standardized detection methods are urgently needed.

2025 Applied Sciences 1 citations
Clinical Trial Tier 1

Microplastics: Clinical Trials Perspectives

This mini review covers the current state of clinical research on microplastics in the human body. Tiny plastic particles have been found in human blood and organs, but studying their effects is challenging due to a lack of standardized methods and ethical guidelines for human trials. The paper highlights that while lab and animal studies provide early data, much more work is needed to understand what microplastics do inside us.

2022 International Journal of Environment and Health Sciences
Article Tier 2

Detection of microplastics in human tissues and organs: A scoping review

This scoping review summarizes studies that have detected microplastics in various human tissues and organs. The review found that microplastics enter the body through multiple routes and have distinct characteristics depending on where they accumulate. The variety of analytical techniques used across studies makes direct comparisons difficult, highlighting the need for standardized methods.

2024 Journal of Global Health 130 citations
Article Tier 2

Microplastics and nanoplastics: Exposure and toxicological effects require important analysis considerations

This review highlights that while microplastics and nanoplastics have been found in human tissues and linked to several diseases, the actual toxic effects are still unclear because researchers use very different methods to study them. The authors call for standardized testing approaches so that results can be compared reliably, which is critical for determining what levels of exposure actually pose a risk to human health.

2024 Heliyon 29 citations
Article Tier 2

Spectro‐Microscopic Techniques for Studying Nanoplastics in the Environment and in Organisms

This review examined spectro-microscopic techniques available for detecting and studying nanoplastics in environmental and biological samples. The study highlights that detecting nanoplastics remains challenging because their small size falls below the detection limits of common analytical tools, and their chemical composition is similar to organic matrices, making identification difficult.

2022 Angewandte Chemie International Edition 55 citations
Article Tier 2

Methodologies to characterize, identify and quantify nano- and sub-micron sized plastics in relevant media for human exposure: a critical review

This review critically evaluated methodologies for characterizing, identifying, and quantifying nano- and sub-micron sized plastics in media relevant to human exposure, highlighting analytical gaps and the need for standardized approaches.

2022 Environmental Science Advances 27 citations
Article Tier 2

Human biomonitoring of microplastics and health implications: A review

This review compiles 91 studies showing that microplastics have been detected in human blood, urine, stool, lung tissue, breast milk, semen, and placenta, confirming widespread human exposure. While our bodies have some ability to clear these particles, microplastics that accumulate in tissues may trigger inflammation, oxidative stress, gut disruption, and reproductive problems. The authors stress that more standardized monitoring methods are needed to fully understand the health consequences.

2023 Environmental Research 83 citations
Article Tier 2

A critical viewpoint on current issues, limitations, and future research needs on micro- and nanoplastic studies: From the detection to the toxicological assessment.

This critical review examines the current methods for detecting and characterizing micro- and nanoplastics in various environmental samples, as well as reported toxic effects from in vivo and in vitro studies. The authors found that while substantial effort has been made to understand microplastic behavior, the scientific community is still far from a complete understanding of how these particles behave in biological systems. The review calls for improved standardized protocols and more studies focused on uptake kinetics, accumulation, and biodistribution.

2019 Environmental Research 163 citations
Article Tier 2

Chemical Analysis of Microplastics and Nanoplastics: Challenges, Advanced Methods, and Perspectives

This review covers the latest laboratory methods for detecting and measuring microplastics and nanoplastics in environmental samples like water, food, and air. Identifying these tiny particles is extremely challenging because they vary enormously in size, shape, and plastic type, and concentrations can differ by billions of times between samples. Better standardized detection methods are essential for accurately understanding how much microplastic humans are actually exposed to.

2021 Chemical Reviews 927 citations