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Papers
20 resultsShowing papers similar to Correlation Between Tumor Differentiation and Biomarkers in Hepatocellular Carcinoma: Implications for Early Diagnosis and Treatment
ClearIdentification and validation of novel signature associated with hepatocellular carcinoma prognosis using Single-cell and WGCNA analysis
This study identified a novel gene signature associated with hepatocellular carcinoma using TCGA datasets and validated key molecular targets with potential prognostic and therapeutic significance. The findings advance understanding of the molecular mechanisms driving liver cancer progression.
Endoplasmic Reticulum Stress-related Classification for Prognosis Prediction in Hepatocellular Carcinoma
Researchers used gene expression data to create an endoplasmic reticulum stress-based classification system for predicting outcomes in liver cancer patients. The model identified patient subgroups with significantly different survival rates.
Endoplasmic Reticulum Stress-Related Signature for Predicting Prognosis and Immune Features in Hepatocellular Carcinoma
Researchers developed a four-gene endoplasmic reticulum stress-based prognostic model for hepatocellular carcinoma using bioinformatics approaches, finding that higher risk scores correlated with advanced tumor stage, HBV infection, and worse survival outcomes. The model also predicted differences in immune cell infiltration profiles, suggesting potential utility for guiding immunotherapy decisions.
Characterization of Microplastics in Human Gastric Cancer and Control Tissues and Analysis of Associated Genetic Features
Researchers detected and characterized microplastics in human gastric cancer tissue and adjacent healthy tissue, finding significantly higher microplastic concentrations in cancer tissue, and used transcriptome sequencing to explore potential molecular mechanisms linking microplastic exposure to gastric cancer development.
Exposure to microplastics and liver oncogenesis: A comprehensive review on molecular mechanisms and pathogenic pathways
Researchers reviewed mechanisms by which microplastic exposure may promote liver cancer, identifying oxidative stress, mitochondrial dysfunction, inflammatory signaling, and epigenetic disruption as key pathways, while noting that microplastics can also carry heavy metals and organic pollutants that synergistically amplify hepatotoxic and carcinogenic risk.
Serum Glutamic Oxalacetic Transaminase Activity as an Index of Liver Cell Injury: a Preliminary Report
Researchers investigated serum glutamic oxalacetic transaminase (SGOT) activity as a biomarker for liver cell injury, presenting preliminary evidence that elevated enzyme levels in serum correlate with hepatocellular damage and could serve as a diagnostic index.
Syringodium isoetifolium Fosters an Antioxidant Defense System, Modulates Glycolytic Enzymes and Protects Membrane Integrity in DEN-induced Hepatocellular Carcinoma in Albino Wistar Rats
This paper is not about microplastics; it investigates the anti-cancer properties of Syringodium isoetifolium seagrass extract in a rat model of liver cancer, finding reduced tumor growth and restored liver tissue architecture.
CYP2E1 deficit mediates cholic acid-induced malignant growth in hepatocellular carcinoma cells
This paper is not about microplastics. It investigated how cholic acid, a bile acid, promotes liver cancer cell growth through a mechanism involving the CYP2E1 enzyme and autophagy signaling pathways. The study is focused on liver cancer biology and has no connection to microplastic pollution.
Microplastics and nanoplastics: Emerging drivers of hepatic pathogenesis and metabolic dysfunction
This review examines emerging evidence linking micro- and nanoplastic exposure to liver disease, including metabolic dysfunction-associated liver disease, cirrhosis, and liver cancer. Researchers found that these particles may contribute to liver damage through oxidative stress, inflammation, and disruption of metabolic pathways. The study highlights the need for further research into how environmental plastic contamination may be influencing the rising rates of liver disease worldwide.
The Expectation and Reality of the HepG2 Core Metabolic Profile
This meta-analysis of 56 metabolomic datasets identified 288 core metabolites in HepG2 liver cells, revealing significant gaps and inconsistencies in how metabolomic studies report and standardize their findings. While focused on cell biology methodology rather than microplastics, HepG2 cells are commonly used in toxicology studies to assess the effects of microplastic exposure on liver function.
Potential toxicity of microplastics on vertebrate liver: A systematic review and meta–analysis
This meta-analysis of 118 studies found that microplastics damage vertebrate livers by inducing oxidative stress and intracellular toxicity, altering biotransformation processes, and disrupting lipid metabolism. Organisms at earlier life stages, exposed to smaller particles, and for longer durations showed the greatest liver damage, with catalase, GST, reactive oxygen species, and alkaline phosphatase levels progressively increasing with microplastic concentration.
Early Predictor Tool of Disease Using Label-Free Liquid Biopsy-Based Platforms for Patient-Centric Healthcare
Algorithmic analysis of patient-derived cell clusters from liquid biopsy samples was combined with tumor models to develop an early disease prediction tool applicable across cancer types. The approach offers a label-free, non-invasive method for early cancer detection that could supplement or reduce reliance on conventional tissue biopsy.
Surface topography of nanoplastics modulates their internalization and toxicity in liver cells
Researchers found that the surface topography of nanoplastics significantly affects their internalization and toxicity in liver cells, revealing that surface roughness and texture modulate how these particles interact with cellular systems.
Polycarbonate nanoplastics and the in vitro assessment of their toxicological impact on liver functionality
Researchers found that polycarbonate nanoplastics and molecular by-products formed during photodegradation both induce toxicity toward hepatocellular functions in liver cell models, demonstrating dual harmful effects from a single degradation process.
The Relationship Between Microplastic Samples in Blood and The Stage of Epithelial Ovarian Cancer at Dr. M. Djamil Padang General Hospital
Researchers investigated the relationship between microplastic levels detected in blood samples and the staging of epithelial ovarian cancer in patients at a hospital in Padang, Indonesia. The study suggests a potential association between blood microplastic burden and cancer stage, though further research is needed to understand the nature of this relationship and any underlying mechanisms.
Identification of functional immune and neuronal tumour cells in glioma
Researchers developed the Single Cell Rule Association Mining (SCRAM) computational tool to integrate RNA-inferred genomic alterations with co-occurring cell type signatures at single-cell resolution, applying it to glioma to identify functional immune and neuronal tumour cells and distinguish tumour from non-tumour cells with greater precision than existing annotation algorithms.
Machine-Learning-Based Bibliometric Analysis of Pancreatic Cancer Research Over the Past 25 Years
Machine learning and semantic analysis were applied to 25 years of pancreatic cancer research publications indexed under medical subject headings, mapping past and current research themes and predicting future directions. The study demonstrates that computational bibliometric methods can reveal evolving research priorities in cancer science more efficiently than traditional literature reviews.
New Progress in Zebrafish Liver Tumor Models: Techniques and Applications in Hepatocellular Carcinoma Research
This review summarizes advances in using zebrafish as models for studying liver cancer, covering techniques like transplantation, genetic modification, and chemical induction. While focused on cancer research methods rather than microplastics directly, zebrafish are increasingly used to study how microplastic exposure affects liver health. The liver tumor models described here could be valuable tools for investigating whether chronic microplastic exposure contributes to liver disease.
Microplastics exacerbate tissue damage and promote carcinogenesis following liver infection in mice
In a mouse study, microplastics significantly worsened liver damage during infection and activated cancer-related genetic pathways, including the tumor suppressor genes p53 and p21. Analysis of liver gene activity showed that microplastics intensified carcinogenesis pathways compared to infection alone, and big data analysis found a correlation between microplastic pollution and human liver cancer rates. While not proof of direct causation, this study raises the possibility that microplastic exposure could promote cancer development in damaged tissues.
Mitochondrial Quality Control and Metabolic Reprogramming in Hepatocellular Carcinoma: Implications for Immunotherapy and Treatment Resistance
Scientists reviewed research showing that liver cancer cells damage the tiny energy factories (mitochondria) inside immune cells, making it harder for the body's natural defenses to fight the cancer. When immune cells can't get enough energy, they become "exhausted" and stop working properly against tumors. The researchers suggest that targeting these energy problems in cells could help improve cancer treatments and make immunotherapy work better for liver cancer patients.