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20 resultsShowing papers similar to Bioactive compounds as potential alternative treatments to prevent cancer therapy-induced male infertility
ClearApigetrin ameliorates doxorubicin prompted testicular damage: biochemical, spermatological and histological based study
Researchers tested whether the flavonoid apigetrin could protect rat testicular tissue from damage caused by the chemotherapy drug doxorubicin. They found that doxorubicin caused significant oxidative stress, inflammation, hormone imbalance, and tissue damage in the testes, but co-administration of apigetrin substantially reduced these harmful effects. The study suggests that natural plant compounds may help protect reproductive health during cancer treatment.
Quercetin alleviates cyclophosphamide-induced premature ovarian insufficiency in mice by reducing mitochondrial oxidative stress and pyroptosis in granulosa cells
Researchers found that quercetin, a natural plant compound, protected mouse ovaries from chemotherapy-induced damage by reducing harmful oxidative stress in mitochondria and suppressing a form of inflammatory cell death called pyroptosis, suggesting it could help preserve fertility in patients undergoing cancer treatment.
Pharmacotherapeutic potential of ginkgetin against polystyrene microplastics–instigated testicular toxicity in rats: A biochemical, spermatological, and histopathological assessment
In a rat study, polystyrene microplastics caused significant damage to the testes, including reduced sperm quality, oxidative stress, and tissue inflammation, but the natural plant compound ginkgetin was able to partially reverse this damage. Ginkgetin worked by boosting antioxidant defenses and reducing the inflammatory response triggered by the microplastics. This suggests that natural antioxidant compounds might help protect male reproductive health from the harmful effects of microplastic exposure.
New Insight on the In Vitro Effects of Melatonin in Preserving Human Sperm Quality
Researchers found that melatonin protects human sperm quality against cadmium-induced oxidative stress in vitro, preserving motility, viability, DNA integrity, and mitochondrial function while reducing lipid peroxidation over 24 hours of exposure.
The Possible Protective Effect of Luteolin in a Thioacetamide Rat Model of Testicular Toxicity
This animal study tested whether luteolin, a natural plant compound with antioxidant properties, could protect against testicular toxicity caused by thioacetamide. The study establishes an animal model for studying reproductive toxicity and evaluates whether natural antioxidants can mitigate oxidative damage to sperm-producing tissues.
Attenuative effect of astilbin on polystyrene microplastics induced testicular damage: Biochemical, spermatological and histopathological-based evidences
Researchers found that astilbin, a natural plant compound, significantly reduced testicular damage caused by polystyrene microplastic exposure in rats. The microplastics disrupted hormone levels, sperm quality, and testicular tissue structure, but astilbin treatment counteracted these effects by boosting antioxidant defenses and reducing inflammation. The study suggests that natural antioxidant compounds may offer protective benefits against the reproductive harm associated with microplastic exposure.
Evaluation of possible attenuative role of chrysoeriol against polyethylene microplastics instigated testicular damage: A biochemical, spermatogenic and histological study
Researchers investigated whether the plant compound chrysoeriol could protect against testicular damage caused by polyethylene microplastics in a rat model. The study found that microplastic exposure reduced antioxidant enzyme activity and increased inflammation markers, while co-administration of chrysoeriol showed a protective effect by mitigating oxidative stress and preserving sperm quality.
Curcumin Attenuates Zearalenone-Induced Reproductive Damage in Mice by Modulating the Gut Microbe–Testis Axis
Researchers investigated whether curcumin, a compound from turmeric, could protect mice from reproductive damage caused by the food-contaminating toxin zearalenone. They found that curcumin improved sperm quality and testicular health by restoring beneficial gut bacteria and reducing inflammation through the gut-testis connection. The study suggests that gut microbiome modulation could be a pathway for protecting reproductive health from environmental toxins.
Curcumin Ameliorates Microplastic-Induced Testicular Inflammatory Damage by Suppressing NLRP3 and WNT/β-Catenin Signaling Pathway Activation
Researchers exposed rodents to microplastics and found the particles triggered two inflammation pathways — NLRP3 inflammasome and WNT/beta-catenin signaling — that together damaged testicular tissue and disrupted sperm-supporting cells. Treatment with curcumin, a compound found in turmeric, suppressed both pathways and largely restored normal function, pointing toward potential natural interventions for microplastic-related reproductive harm.
Metabolic–endocrine remodelling of the testis under polystyrene nanoplastic exposure: Intervention by organ-specific phytocomplexes of Nelumbo nucifera
Researchers found that polystyrene nanoplastics impair testosterone production and sperm quality in male rats by inducing testicular oxidative stress and disrupting cholesterol and energy metabolism, and showed that extracts from lotus plant organs — especially the rhizome — significantly protected testicular function through antioxidant and anti-inflammatory mechanisms.
Oxidative Stress and Male Fertility: Promising Role of Nutraceuticals
This paper is not about microplastics; it reviews the role of oxidative stress in male infertility and the potential of nutraceuticals (antioxidant-rich dietary supplements) to improve sperm quality and hormonal profiles, with no connection to microplastic research.
Transcriptomics and metabolomics reveal functional nanoplastics-induced male reproductive damage and resveratrol antagonistic effects
Scientists found that tiny plastic particles called nanoplastics can seriously damage male fertility in mice by harming sperm production and causing inflammation in the testicles. The good news is that resveratrol, a natural compound found in red grapes and wine, was able to protect against much of this damage. This research matters because nanoplastics are everywhere in our environment and food supply, and this study suggests they could be affecting human male fertility too.
Bioactive Compounds and Their Derivatives: An Insight into Prospective Phytotherapeutic Approach against Alzheimer’s Disease
Researchers reviewed natural bioactive compounds from plant sources for their potential neuroprotective effects related to Alzheimer's disease. The study highlights how these compounds may modulate molecular mechanisms involved in disease development, while noting challenges such as limited bioavailability and blood-brain barrier permeability.
Protective effect of Cordycepin on blood-testis barrier against pre-puberty polystyrene nanoplastics exposure in male rats
Young male rats exposed to polystyrene nanoplastics during a critical growth period developed lasting damage to their reproductive system, including lower sperm quality and weakened barriers protecting developing sperm cells. A natural compound called cordycepin partially reversed this damage by reducing inflammation and oxidative stress, suggesting possible protective strategies against reproductive harm from plastic pollution.
Protective effect of Luffa cylindrica fermentation liquid on cyclophosphamide-induced premature ovarian failure in female mice by attenuating oxidative stress, inflammation and apoptosis
Researchers tested a fermented extract from loofah plants (Luffa cylindrica) as a treatment for chemotherapy-induced ovarian failure in mice, finding it significantly restored hormone levels and reduced ovarian cell damage by suppressing inflammation and cell death pathways. The results suggest this natural fermentation product may help protect fertility in women undergoing toxic chemotherapy treatments.
Pinostrobin alleviates testicular and spermatological damage induced by polystyrene microplastics in adult albino rats
Researchers found that pinostrobin, a natural flavonoid, alleviated testicular damage and sperm abnormalities induced by polystyrene microplastics in rats, suggesting it may be a potential therapeutic candidate for microplastic-related reproductive toxicity.
Toxic effect of polyethylene microplastic on testicles and ameliorative effect of luteolin in adult rats: Environmental challenge
Researchers found that polyethylene microplastics caused significant testicular toxicity in adult rats including reduced sperm quality and testosterone levels, while luteolin treatment ameliorated these effects through its antioxidant and anti-inflammatory properties.
Astragalus Polysaccharides Ameliorate the Toxic Effects of Polystyrene Nanoplastics on Boar Sperm
Scientists found that tiny plastic particles called nanoplastics can damage sperm cells by causing harmful chemical reactions, but a natural compound from the Astragalus plant can help protect against this damage. This study used pig sperm in lab dishes, so we don't know yet if the same protection would work in humans. The findings matter because microplastics are everywhere in our environment and food, and this research suggests natural antioxidants might help reduce their potential harm to reproductive health.
Mechanistic insight into the protective effects of fisetin against arsenic-induced reproductive toxicity in male rats
Researchers showed that arsenic — a heavy metal contaminant found alongside plastic pollution in many environments — severely damages sperm quality and hormone levels in male rats, and that the plant compound fisetin significantly reversed this damage. The results suggest fisetin may help protect male reproductive health from toxic environmental exposures.
Lycopene supplement mitigates polystyrene microplastics (PS-MPs)-induced reproductive alteration in rats via modulation of steroidogenic enzymes, inhibition of apoptosis and oxido-inflammatory reaction
Researchers found that lycopene, a natural antioxidant found in tomatoes, helped protect male rats from reproductive damage caused by polystyrene microplastic exposure. The microplastics disrupted hormone levels and sperm quality, but lycopene supplementation reduced oxidative stress and inflammation in reproductive tissues. The study suggests that dietary antioxidants may help counteract some of the harmful reproductive effects associated with microplastic exposure.