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61,005 resultsShowing papers similar to Tumorigenic and tumoricidal properties of exosomes in cancers; a forward look
ClearMicroplastics as emerging carcinogens: from environmental pollutants to oncogenic drivers
This review examines growing evidence that microplastics and nanoplastics may play a role in cancer development, with these particles found in human tumor tissues from the lungs, colon, stomach, breast, and other organs. The particles appear to promote cancer through chronic inflammation, oxidative stress, DNA damage, and disruption of key cancer-related signaling pathways. While direct proof of causation in humans is still lacking, the accumulating evidence from lab studies, animal experiments, and human tissue analysis suggests microplastics deserve serious attention as potential contributors to cancer risk.
Microplastic and Extracellular Vesicle Interactions: Recent Studies on Human Health and Environment Risks
This review explores the newly discovered relationship between microplastics and extracellular vesicles, tiny particles that cells use to communicate with each other. Evidence indicates that microplastics can alter how these vesicles are distributed and what molecular signals they carry, potentially disrupting normal cell communication. Understanding this interaction could provide important insights into how microplastic exposure may contribute to inflammation, metabolic changes, and other health effects.
The Relationship Between Microplastics and Nanoplastics with Cancer: An Emerging Health Concern
This review explores the emerging relationship between micro- and nanoplastic exposure and cancer risk in humans. Researchers summarized evidence suggesting that microplastics can carry carcinogenic substances and may trigger inflammatory and oxidative stress pathways linked to tumor development. The study highlights that while early evidence raises concern, more research is needed to establish clear causal connections between plastic particle exposure and specific cancer types.
Evaluating the relationship between microplastics and nanoplastics contamination and diverse cancer types development
This review examines growing evidence that micro- and nanoplastics found in human tissues may contribute to cancer development through several pathways. These tiny particles can generate harmful molecules called reactive oxygen species, cause chronic inflammation, and disrupt cell growth signals, all of which are known to promote cancer. While long-term, high-level exposure likely poses the greatest risk, more research is needed to understand the full cancer-related dangers of microplastic exposure.
The micro(nano)plastics perspective: exploring cancer development and therapy
This review explores the emerging link between microplastics and cancer development. Microplastics can trigger chronic inflammation, oxidative stress, and hormone disruption, all of which are known pathways that may promote cancer growth. Interestingly, researchers are also studying whether engineered microplastics could be used as drug carriers for cancer therapy, though long-term effects remain unclear.
From exposure to oncogenesis: a review on the multifaceted roles of microplastics in tumor initiation and progression
This review examined the evidence linking microplastic exposure to tumor initiation and progression, covering physical, chemical, and inflammatory mechanisms by which MPs may promote oncogenesis. The authors conclude that while current evidence is largely preclinical, accumulating data warrant serious concern about microplastics as environmental carcinogens.
Microplastics and Nanoplastics in Cancer Progression: Biology and Public Health
This review examines emerging evidence that microplastics and nanoplastics may contribute to cancer-related processes by crossing biological barriers and accumulating in tissues. The study highlights that these particles can cause oxidative stress, inflammation, DNA damage, and barrier dysfunction at the cellular level, and may promote tumor-supporting processes including angiogenesis and immune evasion.
Microscopic menace: exploring the link between microplastics and cancer pathogenesis
This review examines the growing evidence linking microplastic exposure to cancer development in humans. Microplastics can accumulate in the body and trigger inflammation, oxidative stress, and other biological changes associated with tumor growth. While more clinical research is needed, the review highlights that microplastics should be taken seriously as a potential factor in cancer risk.
Nanotechnology in cancer treatment: revolutionizing strategies against drug resistance
This review explores how nanotechnology is being used to overcome drug resistance in cancer treatment, using materials like carbon nanotubes, dendrimers, and liposomes to deliver drugs more precisely to tumors. While not directly about microplastics, the nanomaterial strategies discussed share relevance with understanding how nano-sized plastic particles interact with human cells and tissues.
Insights into the potential carcinogenicity of micro- and nano-plastics.
This review examined existing evidence on the carcinogenic potential of micro- and nano-plastics, finding studies demonstrating genotoxicity, oxidative DNA damage, disruption of cell signaling, and tumor-promoting effects, while noting that direct human carcinogenicity data remain limited and mechanistic pathways require further investigation.
Do microplastics (MPs) and nanoplastics (NPs) directly contribute to human carcinogenesis?
This review examines whether microplastics and nanoplastics could directly contribute to cancer development in humans. Evidence from lab and animal studies shows these particles can cause DNA damage, chronic inflammation, oxidative stress, and disrupt important cancer-related signaling pathways. While a direct causal link to human cancer has not been proven yet, the review argues that microplastics should be considered potential cancer-promoting agents that warrant urgent further research.
Role of microplastics in the tumor microenvironment (Review)
This review examines how microplastics may help tumors grow by influencing the environment around cancer cells. Microplastics can interact with immune cells, connective tissue cells, blood vessel cells, and the tissue scaffolding around tumors in ways that may promote cancer progression and inflammation. While more research is needed, the findings raise important questions about whether chronic microplastic exposure could affect cancer development in humans.
Nanomaterials in Drug Delivery: Strengths and Opportunities in Medicine
This review covers how nanomaterials are being used to improve drug delivery for treating cancer and infections, offering better targeted therapy with fewer side effects. While not directly about microplastics, the research on how nanoparticles interact with human tissues provides insight into how similarly sized nanoplastics might behave once inside the body.
Microplastics and cancer
This review examines evidence linking microplastics to cancer risk, noting that microplastics have been detected at higher concentrations in human tumor tissues than adjacent healthy tissue, and that they can act as vectors for carcinogens while inducing oxidative stress, inflammation, and genotoxicity.
The Impact of Microplastics on Biological Systems: A Focus on Extracellular Vesicles and miRNA Profiles
This review examines how microplastics affect biological systems with a focus on extracellular vesicles, discussing how MP exposure alters vesicle release and composition in ways that may propagate cellular stress signals throughout tissues and contribute to systemic health effects.
The alarming link between environmental microplastics and health hazards with special emphasis on cancer
This review describes how microplastics enter the human body through the nose, skin, and mouth, then penetrate cells where they can alter gene expression, fuel inflammation, disrupt hormone signaling, and promote uncontrolled cell growth. Studies have linked microplastic exposure to cancers of the lungs, blood, breast, prostate, and ovaries, though the precise molecular mechanisms still need further investigation.
Microplastics and Cancer: A Comprehensive Review of Their Impact on Tumor Progression and Mechanisms of Carcinogenesis
This comprehensive review examines the growing body of evidence linking microplastic exposure to various types of cancer, including colorectal, lung, liver, and breast cancers. Researchers found that microplastics and nanoplastics may promote tumor progression through mechanisms including oxidative stress, chronic inflammation, and disruption of cellular signaling pathways. While the evidence is still emerging, the study highlights the need for further research into the potential cancer-related risks of widespread microplastic exposure.
Rising Concern About the Carcinogenetic Role of Micro-Nanoplastics
This review examined the emerging concern that micro- and nanoplastics may play a role in cancer development, either directly or by carrying chemical carcinogens into the body. Researchers noted that while direct evidence is still limited, the rising incidence of certain cancers in younger populations alongside increasing environmental plastic contamination has raised important questions. The study calls for more focused research to understand whether long-term microplastic exposure may contribute to cancer risk and what preventive measures might be warranted.
Advances in Immunomodulatory Mechanisms of Mesenchymal Stem Cells-Derived Exosome on Immune Cells in Scar Formation
This review examines how exosomes, tiny vesicles released by stem cells, can modulate immune responses and reduce excessive scarring during wound healing. While not directly about microplastics, the immune pathways discussed, particularly inflammation and tissue repair signaling, overlap with those disrupted by microplastic exposure. Understanding these healing mechanisms provides context for how microplastic-driven inflammation might interfere with normal wound repair and tissue recovery in the body.
Micro and nanoplastics in human carcinogenesis: Insights from in vitro studies
This narrative review compiles in vitro evidence on the carcinogenic effects of micro- and nanoplastics across multiple cancer types, examining mechanisms including oxidative stress, DNA damage, immune dysregulation, and epigenetic changes identified in cell culture experiments.
From Exposure to Oncogenesis: the Role of Microplastics and Associated Pollutants in Cancer - a Literature Review
This literature review examined the growing evidence linking microplastic exposure to cancer development. Microplastics have been found in human lung, liver, and colon tissue, and research suggests they may promote cancer through chronic inflammation, oxidative stress, and by carrying known carcinogens like heavy metals and persistent organic pollutants into the body.
Distinct targeting and uptake of platelet and red blood cell‐derived extracellular vesicles into immune cells
This study examined how tiny vesicles (small bubble-like particles) released by platelets and red blood cells interact with immune cells. Platelet-derived vesicles were taken up by certain immune cells much faster than red blood cell vesicles, and neither type affected T-cells. While not directly about microplastics, the research is relevant because it helps scientists understand how small particles in the blood, including nanoplastics, might interact with the immune system.
Microplastics – A Growing Concern as Carcinogens in Cancer Etiology: Emphasis on Biochemical and Molecular Mechanisms
This review describes how microplastics smaller than 5 mm can enter human cells and promote cancer development through multiple pathways, including DNA damage, oxidative stress, chronic inflammation, and disruption of cell growth controls. Microplastics also carry other contaminants into the body, and their accumulation in tissues raises concerns about long-term cancer risk, particularly in the lungs, skin, and digestive system.
Anti-tumor activities of immunotoxins made of monoclonal antibody B3 and various forms of Pseudomonas exotoxin
This paper discusses the prevalence of micro- and nanoplastics and the health concerns they raise, particularly noting that nanoplastics are believed to be more toxic because they can pass through biological barriers. A key challenge is developing reliable detection methods for particles smaller than 1 micrometer.