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61,005 resultsShowing papers similar to Acute Toxicity Assessment of Orally Administered Microplastic Particles in Adult Male Wistar Rats
ClearIn vivo test of acute exposure of polyethylene microplastics on kidney and liver of Rattus norvegicus Wistar strain rats
Researchers exposed male rats to a single dose of polyethylene microplastics and monitored them for 14 days, finding significant changes in body weight, elevated markers of kidney and liver stress in blood tests, and visible tissue abnormalities under microscopy. The results indicate that even short-term, high-dose microplastic exposure can cause measurable organ damage in mammals.
Renal and Hepatotoxic Effects of Polyethylene Terephthalate Microplastics in Chronically Exposed Albino Rats
Researchers exposed albino rats to different doses of PET microplastics for 90 days and measured kidney and liver function markers. They found that chronic exposure led to significant changes in serum urea, creatinine, and liver enzymes, suggesting potential kidney and liver damage at higher doses. The study also found that water stored in PET containers exposed to sunlight showed similar toxic effects, raising concerns about everyday plastic container use.
Early Physiological and Biochemical Responses to Short-Term Oral Exposure to Microplastic Particles in Male Wistar Rats
Scientists fed rats tiny plastic particles from water bottles and found changes in their blood chemistry and drinking habits within just 24 hours, even though the rats appeared healthy on the outside. This study suggests that microplastics—which people consume daily through food and drinks—might start affecting our bodies much faster than previously thought. The research highlights the need to better understand these immediate effects, as they could lead to bigger health problems over time.
Dose‐Dependent Toxicological Effects of Polyvinyl Chloride and Polystyrene Microplastics on Wistar Albino Rats
Researchers fed rats PVC and polystyrene microplastics at different doses for eight weeks and observed significant changes including weight loss, elevated blood glucose, increased cholesterol and liver enzymes, and signs of oxidative stress. The study suggests that oral microplastic exposure at these levels can cause dose-dependent toxicological effects across multiple organ systems in mammals.
A single oral exposure to polyethylene terephthalate microplastics causes mild metabolic and gastrointestinal disruption: dose and sex determinants
Researchers gave male and female rats a single oral dose of PET microplastics derived from cryomilled nurdles and monitored metabolic rate, gene expression, and blood biomarkers for 18 hours, finding sex- and dose-dependent effects including decreased metabolic rate, altered duodenal gene expression in males, and elevated LDL in females, suggesting mild but measurable systemic disruption.
A single oral exposure to polyethylene terephthalate microplastics causes mild metabolic and gastrointestinal disruption: dose and sex determinants
Researchers gave male and female rats a single oral dose of PET microplastics derived from cryomilled nurdles and monitored metabolic rate, gene expression, and blood biomarkers for 18 hours, finding sex- and dose-dependent effects including decreased metabolic rate, altered duodenal gene expression in males, and elevated LDL in females, suggesting mild but measurable systemic disruption.
Polyethylene microplastics disrupt renal function, mitochondrial bioenergetics, redox homeostasis, and histoarchitecture in Wistar rats
Researchers gave rats polyethylene microplastics orally for 28 days and found dose-dependent kidney damage, including impaired filtration, electrolyte imbalances, and tissue inflammation. The microplastics depleted antioxidant defenses, increased oxidative stress markers, and disrupted mitochondrial energy production in kidney cells, identifying the kidneys as a critical target of microplastic toxicity.
A single oral exposure to polyethylene terephthalate microplastics causes mild metabolic and gastrointestinal disruption: dose and sex determinants
Researchers gave male and female rats a single oral dose of PET microplastics at 5 or 50 mg/kg and monitored metabolic rate, respiratory exchange ratio, and tissue gene expression for 18 hours, finding sex- and dose-dependent disruptions including decreased metabolic rate, altered duodenal gene expression in males, and increased serum LDL in females, suggesting mild but measurable metabolic and gastrointestinal effects.
Kidney and Liver Disorders Due to Microplastic Exposure: Chronic in Vivo Study in Male White Rats
Male white rats were chronically exposed to microplastics (particles 5 mm or smaller) to assess kidney and liver toxicity, with exposure resulting from environmental weathering and ultraviolet irradiation of plastic materials. The study found measurable histopathological and biochemical damage in both organs, confirming that long-term microplastic exposure causes organ-level injury in mammals.
Chronic Microplastic Exposure Dose‐Dependently Induces Liver Failure via Oxidative Stress, Inflammation, and Apoptosis in Rats
This animal study found that chronic exposure to polyethylene microplastics caused dose-dependent liver damage in rats over just four weeks. Higher doses led to increased markers of liver injury, oxidative stress, inflammation, and cell death, suggesting that ongoing microplastic ingestion could harm liver health over time.
Nanoplastics-induced oxidative stress, antioxidant defense, and physiological response in exposed Wistar albino rats
Researchers orally exposed Wistar rats to polystyrene nanoplastics at multiple doses for five weeks and observed dose-dependent increases in oxidative stress. The study found significant alterations in liver and kidney function markers, disrupted energy metabolism, and changes in antioxidant enzyme activity, suggesting that nanoplastic exposure may affect multiple organ systems in mammals.
Microplastic Exposure Impairs Weight Gain, Reproduction, Blood Glucose Levels, and Organ Health in Rats (Rattus norvegicus)
Rats orally exposed to microplastic solutions at 1–10% concentrations over 28 days showed dose-dependent impairment of weight gain, reproductive function, blood glucose regulation, and organ health compared to controls—providing mammalian in vivo evidence that microplastic ingestion causes systemic physiological harm.
Potential Effects of Orally Ingesting Polyethylene Terephthalate Microplastics on the Mouse Heart
This study found that mice fed PET microplastics (the type of plastic used in water bottles and food containers) developed heart damage, including broken muscle fibers, significant scarring, and cell death in heart tissue. The damage was driven by a buildup of harmful oxygen molecules (oxidative stress) that overwhelmed the heart's natural defenses. These findings raise concern about the potential cardiovascular effects of PET microplastics that humans commonly encounter in food and drink packaging.
Acute and subacute repeated oral toxicity study of fragmented microplastics in Sprague-Dawley rats
Researchers conducted acute and subacute oral toxicity studies of weathered polypropylene microplastics in rats, using realistic fragmented particles to assess health effects from dietary microplastic exposure, providing toxicological data relevant to human food safety.
Effect of Microplastic Intake on Intestinal and Pancreatic Cell Damage
Researchers investigated the effects of oral microplastic administration on the intestinal and pancreatic cells of Rattus norvegicus Wistar rats to assess organ-level damage from ingestion via contaminated food and drink. Using a quantitative experimental design, they found that oral microplastic intake impairs the function of the small intestine, large intestine, and pancreas, providing experimental evidence for cellular damage in key digestive and endocrine organs following microplastic ingestion.
Physiological stress response of the Wistar albino rats orally exposed to polystyrene nanoparticles
Rats given oral doses of polystyrene nanoparticles for five weeks showed dose-dependent increases in oxidative stress markers and changes in liver and kidney enzyme levels. The findings suggest that ingested nanoplastics can cause biochemical stress in mammals, providing data relevant to assessing human health risks.
Evaluation of Liver Function Through SGOT and SGPT Quantification in Rats Administered Polyethylene Terephthalate Microplastics
Researchers administered PET microplastics orally to white rats at doses of 0.4–1.0 mg/day and measured SGOT and SGPT liver enzyme levels, finding dose-dependent increases in both transaminases indicating hepatotoxicity even at low exposure levels.
Microplastics exposure altered hematological and lipid profiles as well as liver and kidney function parameters in albino rats (Rattus norvegicus)
Researchers fed albino rats different concentrations of microplastics for 28 days and measured changes in blood, liver, kidney, and lipid profiles. They found dose-dependent effects including reduced immune cell counts suggesting immunosuppression, lower red blood cell levels indicating anemia, and altered liver and kidney function markers. The study provides evidence that microplastic ingestion may affect multiple organ systems and blood health in a way that worsens with higher exposure levels.
Exploring the Impacts of Polyethylene Microplastics on Rat Liver
Wistar rats exposed to polyethylene microplastics at 0.1–5 mg/kg for 4 weeks showed dose-dependent PE accumulation in liver tissue confirmed by fluorescence microscopy, with histopathological signs of liver injury despite no significant change in body weight.
Preliminary study of polyethylene microplastics disrupting energy Metabolism, redox Balance, and prefrontal cortex structure in Wistar rats
Researchers examined the neurotoxic effects of polyethylene microplastics on the prefrontal cortex of rats over a 28-day oral exposure period. The study found that microplastic exposure disrupted energy metabolism, impaired mitochondrial redox balance, and triggered inflammatory responses in brain tissue, suggesting that microplastics may pose risks to neurological function.
Sub-acute polyethylene microplastic inhalation exposure induced pulmonary toxicity in wistar rats through inflammation and oxidative stress
Researchers exposed rats to airborne polyethylene microplastics through inhalation for 28 days and found significant signs of lung damage. The exposed animals showed increased inflammation markers, elevated oxidative stress, and tissue changes in the lungs compared to controls. The study provides evidence that breathing in microplastic particles from degraded plastic bags and bottles may cause pulmonary toxicity.
Toxicity and mechanism analysis of microplastics
This review summarized experimental evidence on the toxicity and mechanisms of action of microplastics across animal models, covering effects from ingestion including organ damage, oxidative stress, and immune disruption. The synthesis aimed to inform risk assessment for environmental and human health impacts of microplastic exposure.
Hematological consequences of polyethylene microplastics toxicity in male rats: Oxidative stress, genetic, and epigenetic links
Researchers gave male rats different doses of polyethylene microplastics orally for 35 days and found significant damage to blood cells and the blood-forming system. Higher doses caused oxidative stress, DNA damage, and changes in gene expression patterns related to blood cell production. The study suggests that chronic microplastic ingestion could harm the blood system through both genetic and epigenetic pathways.
Organ-specific accumulation and toxicity analysis of orally administered polyethylene terephthalate microplastics
When mice were fed tiny PET plastic particles (the kind found in water bottles and food containers), the particles accumulated mainly in the lungs and caused inflammatory damage at higher doses. The study found that male mice were more sensitive than females, and the results highlight that microplastics swallowed through food and drink can travel to and harm organs beyond the digestive system.