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61,005 resultsShowing papers similar to Combined effect of polystyrene nanoplastic and di-n-butyl phthalate on testicular health of male Swiss albino mice: analysis of sperm-related parameters and potential toxic effects
ClearChemical Cocktail: Understanding PSNP and DBP Impact on Testicular Health of Swiss albino mice
A 60-day study in male mice found that polystyrene nanoplastics and the common plasticizer di-n-butyl phthalate (DBP) each impaired sperm quality and testicular structure, but combining the two caused even greater damage — including tubular degeneration, oxidative stress, and structural lesions — than either substance alone. This suggests that real-world simultaneous exposures to nanoplastics and chemical additives they carry could pose compounded reproductive health risks.
Polystyrene nanoplastics aggravated dibutyl phthalate-induced blood-testis barrier dysfunction via suppressing autophagy in male mice
In a mouse study, polystyrene nanoplastics combined with dibutyl phthalate (a common plasticizer chemical) caused significantly worse damage to the blood-testis barrier than either substance alone. The nanoplastics carried the phthalate into the reproductive system, where the combination reduced sperm quality, impaired sperm development, and damaged the protective barrier around the testes. This research shows how nanoplastics can make other common plastic chemicals more dangerous to male fertility.
Polystyrene nanoparticles enhance the adverse effects of di-(2-ethylhexyl) phthalate on male reproductive system in mice
Researchers investigated the combined reproductive toxicity of polystyrene nanoparticles and the plasticizer DEHP in male mice over 35 days. The study found that co-exposure to nanoparticles and DEHP produced enhanced adverse effects on sperm quality and testicular tissue compared to either substance alone, suggesting nanoplastics may amplify the endocrine-disrupting effects of plasticizers.
Combined effects of polystyrene nanoplastics and lipopolysaccharide on testosterone biosynthesis and inflammation in mouse testis
Researchers found that polystyrene nanoplastics combined with bacterial toxins (LPS) caused worse damage to mouse testicles than either substance alone, reducing sperm count, lowering testosterone levels, and increasing inflammation. Since microplastics in the environment can carry bacteria and their toxins, this combination exposure is realistic. The findings suggest that nanoplastic pollution could amplify the reproductive harm caused by bacterial infections in males.
Combined exposure to titanium nanoparticles and nanoplastics damages the male reproductive system and sperm activity
This study assessed the effects of combined TiO2 nanoparticles and polystyrene nanoplastics on male reproductive function in animal models, finding that co-exposure caused greater damage to sperm motility, testicular structure, and hormone levels than either material alone. The results raise concerns about combined environmental exposure to two common industrial nanomaterials.
Polystyrene nanoplastics aggravate reproductive system damage in obese male mice by perturbation of the testis redox homeostasis
Researchers found that polystyrene nanoplastics worsened reproductive damage in male mice already fed a high-fat diet, reducing sperm quality and testosterone production beyond what obesity alone caused. The nanoplastics disrupted the protective blood-testis barrier and increased oxidative stress in reproductive tissues. The study suggests that nanoplastic exposure combined with obesity may create compounding risks to male fertility.
Co-exposure to polystyrene nanoplastics and hexachlorocyclohexane induces enhanced human sperm toxicity in vitro
Scientists found that when human sperm are exposed to both tiny plastic particles (nanoplastics) and a pesticide chemical at the same time, it causes much more damage than either substance alone. The combination severely reduced sperm's ability to swim and function properly, which could contribute to male fertility problems. This suggests that the growing presence of microplastics in our environment might make other harmful chemicals even more dangerous to reproductive health.
The single and combined effects of decabromodiphenyl ethane and mixed microplastics on male mice reproductive toxicity
Researchers investigated the combined reproductive toxicity of mixed microplastics and the flame retardant DBDPE in male mice over seven weeks. The study found that DBDPE alone decreased sex hormone levels and sperm count, and when combined with microplastics, the effects on testicular damage, sperm malformation, and oxidative stress were compounded, suggesting that microplastics may amplify the toxicity of co-occurring chemical contaminants.
Synergistic assault of DEHP and MPs: Unmasking the ER stress-triggered autophagic injury male fertility
Researchers found that mice co-exposed to microplastics and the common plasticizer DEHP through drinking water experienced severe impairment of male reproductive function, including disrupted testicular structure, declining sperm quality, and hormonal dysregulation. The combined exposure activated endoplasmic reticulum stress and triggered excessive autophagy, contributing to reproductive damage beyond what either pollutant caused alone. The study highlights the significant risks of simultaneous exposure to microplastics and plastic additives for male fertility.
Arsenic and polystyrene-nano plastics co-exposure induced testicular toxicity: Triggers oxidative stress and promotes apoptosis and inflammation in mice.
Combined exposure of mice to polystyrene nanoplastics and arsenic caused greater testicular damage than either pollutant alone, with co-exposure triggering amplified oxidative stress, apoptosis, and inflammatory signaling in testicular tissue, pointing to compounding reproductive toxicity from these co-occurring environmental contaminants.
Oral exposure to polystyrene nanoplastics reduced male fertility and even caused male infertility by inducing testicular and sperm toxicities in mice
Researchers fed male mice polystyrene nanoplastics of different sizes (25, 50, and 100 nm) for 56 days and found that all sizes reduced fertility and some caused complete infertility. The nanoplastics accumulated in the testes, causing oxidative stress, cell death, and inflammation that damaged sperm and reproductive tissue. This study raises concerns that human exposure to nanoplastics through food and water could contribute to declining male fertility.
Combined effect of polystyrene microplastics and cadmium on rat blood-testis barrier integrity and sperm quality
Researchers exposed male rats to polystyrene microplastics and cadmium, both separately and together, and found that both substances damaged testicular tissue, disrupted the blood-testis barrier, and reduced sperm quality. Notably, the combined exposure was less severe than cadmium alone, likely because microplastics absorbed some cadmium in the gut and reduced its bioavailability. The study also found for the first time that microplastics trigger autophagy in reproductive cells as a protective response.
Exposure to polystyrene nanoplastics impairs sperm metabolism and pre-implantation embryo development in mice
This study found that male mice given polystyrene nanoplastics by mouth showed significant harm to sperm function and early embryo development, with changes in gene expression that could affect offspring. The findings raise concerns that nanoplastic exposure could impair male fertility and potentially pass harmful effects to the next generation.
The emerging risk of exposure to nano(micro)plastics on endocrine disturbance and reproductive toxicity: From a hypothetical scenario to a global public health challenge
Researchers administered polystyrene nanoplastics orally to male rats for five weeks and found significant reductions in testosterone, LH, and FSH levels, sperm DNA damage, altered testicular gene expression, and dose-dependent histological lesions, indicating that nanoplastic exposure disrupts the hormonal axis governing male reproductive function.
The male reproductive toxicity after nanoplastics and microplastics exposure: Sperm quality and changes of different cells in testis
A mouse study compared the reproductive toxicity of nanoplastics versus microplastics and found that both damaged the testes after 12 weeks of exposure, but microplastics caused more severe harm in some measures. The plastics disrupted sperm production, caused inflammation and oxidative stress, and damaged the cells that support sperm development. These findings suggest that plastic particle exposure could contribute to male fertility problems, with different particle sizes affecting reproductive health through different biological pathways.
Prenatal and postnatal exposure to polystyrene microplastics induces testis developmental disorder and affects male fertility in mice
Researchers exposed pregnant mice and their offspring to polystyrene microplastics from gestation through early life and found significant disruption to testicular development and male reproductive function. The exposed males showed reduced sperm quality, lower testosterone levels, and structural damage to testicular tissue. The study suggests that early-life microplastic exposure may have lasting effects on male fertility.
Combined exposure of PS-MPs with NaF induces Sertoli cell death and dysfunction via ferroptosis and apoptosis
This study found that polystyrene microplastics combined with sodium fluoride caused far worse damage to testicular cells in mice than either substance alone. The combination triggered both ferroptosis (iron-dependent cell death) and apoptosis (programmed cell death) in Sertoli cells, which are essential for sperm production. Since both fluoride and microplastics are common environmental contaminants, their combined effect on male reproductive health is a growing concern.
Co-exposure to polystyrene microplastics and microcystin-LR aggravated male reproductive toxicity in mice
Researchers found that exposing mice to a combination of polystyrene microplastics and microcystin-LR, a toxin produced by algae, caused more severe damage to male reproductive organs than either pollutant alone. The microplastics increased the amount of the toxin that accumulated in testicular tissue. The study suggests that the interaction between microplastics and other environmental contaminants may amplify reproductive health risks.
Toxicity to the Male Reproductive System after Exposure to Polystyrene Nanoplastics: A Macrogenomic and Metabolomic Analysis
Researchers exposed male mice to polystyrene nanoplastics of different sizes through their drinking water for four months and found significant harm to reproductive function. The nanoplastics disrupted gene activity and metabolic pathways in the gut, which was linked to reduced sperm quality and testicular damage. The study suggests that long-term nanoplastic exposure through drinking water may pose risks to male reproductive health.
Polystyrene microplastics induced male reproductive toxicity in mice
Researchers exposed male mice to polystyrene microplastics of different sizes and found that the particles accumulated in testicular tissue and entered reproductive cells. After 28 days of exposure, sperm quality and testosterone levels declined, and tissue examination revealed disorganized sperm-producing cells and inflammation. The study suggests that microplastic exposure may pose risks to male reproductive health in mammals.
Subchronic co-exposure of polystyrene nanoplastics and 3-BHA significantly aggravated the reproductive toxicity of ovaries and uterus in female mice
Researchers exposed female mice to polystyrene nanoplastics combined with 3-BHA (a food preservative) for 35 days and found that the combination caused significantly worse damage to ovaries and uterus than either substance alone. The co-exposure led to reduced organ size, hormonal disruption, increased cell death, and heightened inflammation in reproductive tissues. This is concerning because humans are regularly exposed to both nanoplastics and food additives like 3-BHA simultaneously.
Exploring the Biological Effects of Polystyrene Nanoplastics on Spermatogenesis: Insights From Transcriptomic Analysis in Mouse Spermatocytes
Researchers exposed mouse spermatocytes to polystyrene nanoplastics and observed membrane disruption, mitochondrial damage, increased oxidative stress, and DNA damage within 24 hours. Transcriptomic analysis revealed 134 genes with altered expression, many linked to critical reproductive processes like sperm development and mitochondrial organization. The study suggests that nanoplastic exposure may interfere with male reproductive health at the cellular and genetic level.
Enhanced reproductive toxicities induced by phthalates contaminated microplastics in male mice (Mus musculus)
Researchers investigated the combined reproductive toxicity of phthalate-contaminated microplastics in male mice over a 30-day exposure period. They found that microplastics enhanced the accumulation of phthalates in the liver and gut, and the combination significantly worsened reproductive damage including reduced sperm quality and testicular tissue changes. The study suggests that microplastics may amplify the harmful effects of chemical contaminants they carry by increasing their bioavailability in the body.
Maternal exposure to phthalates and nanoplastics, isolated or combined: Impacts on placental structure, development, and antioxidant defense as a trigger for maternal-fetal adversities
Researchers exposed pregnant rats to a mixture of phthalates and nanoplastics, both separately and in combination, to study effects on the placenta and fetal development. They found that combined exposure caused more severe damage to placental structure and antioxidant defenses than either contaminant alone. The study suggests that simultaneous exposure to these common plastic-derived pollutants during pregnancy may compound risks to maternal and fetal health.