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61,005 resultsShowing papers similar to Drosophila melanogaster as a Bioindicator in Comparative Copper and Lead Toxicology: Exploring the Health Implications of Heavy Metal Exposure
ClearDrosophila melanogaster as sentinel organism for hazard identification of environmental contaminants
This review highlights how the common fruit fly (Drosophila melanogaster) is being used as a model organism to study the toxic effects of environmental pollutants, including microplastics, nanomaterials, and heavy metals. Researchers found that fruit flies offer genetic tools and measurable endpoints like survival, reproduction, and behavior that make them valuable for identifying hazards and discovering biomarkers. The study underscores the fruit fly's growing role in advancing our understanding of how environmental contaminants affect living organisms.
Drosophila melanogaster as a dynamic in vivo model organism reveals the hidden effects of interactions between microplastic/nanoplastic and heavy metals
Researchers used Drosophila melanogaster as an in vivo model to reveal that interactions between micro/nanoplastics and heavy metals produce combined toxic effects that are more severe than exposure to either contaminant alone.
Drosophila melanogaster as a tractable eco-environmental model to unravel the toxicity of micro- and nanoplastics
This review summarizes research using fruit flies as a model to study how micro- and nanoplastics harm living organisms. Studies show these tiny plastic particles cause oxidative stress, inflammation, DNA damage, and reproductive problems in flies, with males being more vulnerable than females -- findings that may help us understand similar risks in humans.
Drosophila melanogaster as an indispensable model to decipher the mode of action of neurotoxic compounds
This review assessed Drosophila melanogaster as a model organism for studying the neurotoxic mechanisms of environmental contaminants, highlighting its genetic similarity to mammals and well-characterized neural architecture. The authors catalogued how different categories of neurotoxicants including pesticides, heavy metals, and plastic-associated chemicals affect Drosophila behavior and brain development.
Nanoplastics and Microplastics and Their Impact on Male Reproduction—Uncovering the Hidden Hazards Using the Drosophila Model
Using Drosophila as a model organism, researchers investigated the impact of micro- and nanoplastics on male reproductive health, finding that exposure impaired reproductive output and sperm quality. The study validates Drosophila as an ethical, cost-effective model for assessing reproductive toxicity of microplastics.
Exposure to microplastics cause gut damage, locomotor dysfunction, epigenetic silencing, and aggravate cadmium (Cd) toxicity in Drosophila
Researchers used fruit flies as a model to study the effects of microplastics alone and combined with cadmium, a toxic metal commonly used in plastic production. They found that microplastics caused size-dependent gut damage and enhanced cadmium's harmful effects on movement and gene regulation through epigenetic silencing. The study demonstrates that microplastics can amplify the toxicity of co-occurring environmental contaminants and suggests Drosophila as a useful tool for rapid microplastic toxicity screening.
Interactions of ingested polystyrene microplastics with heavy metals (cadmium or silver) as environmental pollutants: a comprehensive in vivo study using drosophila melanogaster
This study used fruit flies to investigate how polystyrene microplastics interact with two heavy metal pollutants — cadmium and silver — after ingestion. The combined exposures demonstrated that microplastics can alter the toxic effects of heavy metals, supporting the concern that microplastics act as carriers that change how harmful metals affect living organisms.
Application of Drosophila Melanogaster as the Test Object for Assessing the Environmental Status of Environmental Objects and Ecosystems
This is a Ukrainian-language abstract describing the use of fruit flies as test organisms for assessing ecological conditions — not a full research article with detailed findings to summarize.
Drosophila melanogaster as potential alternative animal model for evaluating acute inhalation toxicity
Researchers tested fruit flies as an alternative animal model for studying inhalation toxicity of common antimicrobial chemicals. They found that higher exposure concentrations led to lower survival rates and impaired movement and neurological responses in the flies. The study suggests that fruit flies could serve as a reliable and efficient model for evaluating the harmful effects of inhaled substances.
The effects of microplastics and nanoplastics upon history, policies, and Drosophila melanogaster
This study examined the effects of microplastics and nanoplastics on the fruit fly Drosophila melanogaster, finding that dietary exposure to these pervasive environmental contaminants causes measurable biological harm and making the case for stronger regulatory policies.
Effects of cadmium on oxidative stress and cell apoptosis in Drosophila melanogaster larvae
Researchers exposed fruit fly larvae to increasing doses of cadmium — a heavy metal pollutant — and found rising levels of DNA damage, oxidative stress (cell-damaging reactive oxygen), and activation of cell death genes, even at lower concentrations. The findings add to evidence that heavy metal contamination, which often accompanies plastic pollution in the environment, causes serious genetic and cellular harm to developing organisms.
Study on Chemically-induced Diet Alteration of Drosophila Melanogaster
This study used Drosophila melanogaster as an in vivo model to assess how chemical compounds — including plastic-associated chemicals — alter feeding behavior and development, evaluating the fruit fly's diet alteration response as a sensitive toxicity endpoint for environmental contaminant screening.
Interactions of Ingested Polystyrene Microplastics with Heavy Metals (Cadmium or Silver) as Environmental Pollutants: A Comprehensive In Vivo Study Using Drosophila melanogaster
Researchers used Drosophila larvae to study polystyrene microplastic interactions with cadmium and silver, visualizing plastic passage through the intestinal barrier into hemolymph and finding that co-exposure to metals and microplastics produced synergistic toxic effects.
Transgenerational effects on development following microplastic exposure in Drosophila melanogaster
Researchers fed Drosophila melanogaster flies plastic-supplemented food and found that while treated flies showed changes in fertility and sex ratio, their unexposed offspring had shorter larval development and reduced adult size, demonstrating transgenerational developmental effects from parental microplastic exposure.
No evidence for behavioral or physiological effects of nanoplastics ingestion in the fruit fly Drosophila melanogaster
Researchers exposed Drosophila melanogaster to low and high concentrations of nanoplastics (1 µg/g and 1 mg/g) across several generations and measured emergence rate, mitochondrial activity, metabolism, body mass, and locomotion. No significant behavioral or physiological effects were detected, suggesting Drosophila may be less sensitive to nanoplastics than aquatic species.
Nanoplastics exacerbate lead exposure-induced developmental neurotoxicity by disrupting gut integrity in Drosophila
Researchers used Drosophila fruit flies to show that co-exposure to nanoplastics and lead is more neurodevelopmentally damaging than lead alone, with nanoplastics promoting lead accumulation in neural tissue, disrupting gut integrity, and worsening oxidative stress, learning deficits, and motor impairment — with female flies showing greater sensitivity.
Effects of PET microplastics on the physiology of Drosophila
Researchers used Drosophila fruit flies as a model to study the physiological effects of PET microplastics, finding that ingestion affected reproduction, lifespan, and gut function. The study suggests that even common plastic types found in food packaging can have measurable biological effects when consumed by living organisms.
Polypropylene microplastics affect the physiology in Drosophila model
Researchers found that polypropylene microplastics negatively affected the physiology of Drosophila fruit flies, complementing earlier work on polyethylene terephthalate microplastics and demonstrating that different polymer types can impair organism health.
A comparison of carbon dot and CdTe quantum dot toxicity in Drosophila melanogaster
Researchers compared the toxicity of carbon dots and cadmium telluride quantum dots using fruit flies as a model organism. They found that carbon dots were significantly less toxic than the cadmium-based quantum dots. The study suggests that carbon-based nanomaterials may offer a safer alternative for applications where quantum dots are currently used.
Toxicological Profile of Polyethylene Terephthalate (PET) Microplastic in Ingested Drosophila melanogaster (Oregon R+) and Its Adverse Effect on Behavior and Development
Researchers fed PET microplastics to fruit flies and found that the particles accumulated in their bodies and caused dose-dependent declines in movement, climbing ability, and survival rates. Higher microplastic concentrations also slowed the flies' development from larvae to adults. While fruit flies are a simple model organism, these behavioral and developmental effects suggest that chronic microplastic ingestion could impair neurological and physiological functions in animals exposed through their diet.
Polyethylene microplastics affect behavioural, oxidative stress, and molecular responses in the Drosophila model
Fruit flies exposed to polyethylene microplastics showed reduced climbing and crawling ability, increased oxidative stress, and activation of genes involved in cell death and stress responses. The microplastics overwhelmed the flies' antioxidant defenses and triggered the same cellular damage pathways associated with disease in mammals. Since fruit flies share many biological pathways with humans, these findings suggest that microplastic exposure could cause similar oxidative damage and stress responses in human cells.
Assessing genotoxic effects of plastic leachates in Drosophila melanogaster
Researchers exposed fruit flies to chemicals leached from conventional and oxodegradable polypropylene and polyethylene plastics and found that while the flies appeared healthy on the surface, their DNA suffered chromosomal damage and genetic instability in neural tissue. These findings raise concern that plastic leachates — chemicals that seep out of plastic waste — may carry hidden genetic risks for organisms living in contaminated soil.
MultigenerationalEffects of Weathered PolyethyleneMicroplastics on Drosophila melanogaster
Researchers tracked multigenerational effects of weathered polyethylene microplastics on Drosophila melanogaster, finding that fitness effects including reduced fecundity and lifespan became more pronounced in later generations even when offspring were not directly exposed.
Exposure to polystyrene microplastic beads causes sex-specific toxic effects in the model insect Drosophila melanogaster
Researchers fed fruit flies (Drosophila) polystyrene microplastics and found toxic effects that differed between males and females. Exposed flies showed changes in feeding behavior, digestion, and excretion, with females experiencing greater reproductive impacts. This study is significant because it demonstrates that microplastic toxicity can be sex-specific, suggesting that health effects in humans might also differ between men and women.