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61,005 resultsShowing papers similar to Pulmonary toxicity assessment of polypropylene, polystyrene, and polyethylene microplastic fragments in mice
ClearPulmonary Toxicity of Polystyrene, Polypropylene, and Polyvinyl Chloride Microplastics in Mice
Researchers tested the lung toxicity of three common microplastic types (polystyrene, polypropylene, and polyvinyl chloride) in mice and found that all three caused pulmonary inflammation, but through different mechanisms. Polyvinyl chloride produced the most severe inflammatory response, while polystyrene and polypropylene showed distinct patterns of immune activation. The study suggests that the type of plastic inhaled matters for understanding respiratory health risks from airborne microplastics.
Microplastics and nanoplastics, emerging pollutants, increased the risk of pulmonary fibrosis in vivo and in vitro: A comparative evaluation of their potential toxicity effects with different polymers and size
Researchers compared the lung toxicity of microplastics and nanoplastics made from polystyrene, polyethylene, and polypropylene in mice and human lung cells. They found that all particle types induced signs of pulmonary fibrosis, inflammation, and tissue remodeling, with polystyrene nanoplastics causing the most severe effects. The study suggests that smaller nanoplastic particles and certain polymer types may pose greater risks to lung health.
Deleterious effects of microplastics and nanoplastics on rodent lungs: a systematic review
This systematic review summarizes research on how inhaled micro- and nanoplastics affect the lungs in animal studies. The findings show these particles can cause lung inflammation, tissue damage, and immune responses, suggesting that breathing in airborne microplastics may pose real risks to respiratory health.
Investigation of Pulmonary Inflammatory Responses Following Intratracheal instillation of and Inhalation exposure to Polypropylene Microplastics
Researchers conducted short-term pulmonary toxicity studies by exposing mice to polypropylene microplastics via intratracheal instillation and inhalation, finding dose-dependent inflammatory responses in lung tissue that confirm inhalation as a significant exposure route of concern.
In vivo toxicity assessment of microplastics in Balb/C mice : study of inhalation exposure and its inflammatory effects
Researchers examined the in vivo toxicity of inhaled microplastics in Balb/C mice, studying pulmonary inflammation, oxidative stress, and systemic effects following repeated inhalation exposure. The study found dose-dependent lung inflammation and evidence of particle translocation to other organs.
Microplastics inhalation: evidence in human lung tissue
Microplastic particles were found in human lung tissue samples collected during surgery, confirming that people inhale and retain microplastics in pulmonary tissue, with polypropylene and polyethylene terephthalate among the polymers identified, raising concerns about chronic respiratory and inflammatory effects.
Chronic lung tissue deposition of inhaled polyethylene microplastics may lead to fibrotic lesions
In a mouse study, inhaled polyethylene microplastics accumulated in lung tissue over 90 days of repeated exposure, causing chronic inflammation, immune changes, and early signs of lung scarring (fibrosis). Even at the lowest doses, the microplastics triggered inflammatory cell buildup and thickening of lung walls. These findings suggest that long-term breathing of airborne microplastics could lead to permanent lung damage, which is concerning given rising levels of plastic particles in indoor and outdoor air.
Size-Dependent Pulmonary Toxicity and Whole-Body Distribution of Inhaled Micro/Nanoplastic Particles in Male Mice from Chronic Exposure
Researchers exposed mice to airborne micro- and nanoplastic particles through normal breathing over an extended period and found the highest accumulation in the lungs, followed by the blood and spleen. Surprisingly, the larger 1-micrometer microplastics caused more severe lung damage than the smaller 80-nanometer particles, triggering inflammation, cell death, and scarring. These findings highlight that breathing in airborne plastic particles poses real health risks, with particle size playing an important role in the type of damage caused.
Presence of airborne microplastics in human lung tissue
Researchers examined human lung tissue from autopsies and found microplastic particles and fibers in 13 out of 20 samples. The most common plastics were polyethylene and polypropylene, with particles smaller than 5.5 micrometers. This study provides direct evidence that inhaled microplastics accumulate in human lungs, raising concerns about potential long-term effects on respiratory health.
Polystyrene microplastic particles: In vitro pulmonary toxicity assessment
Researchers tested the effects of polystyrene microplastics on human lung cells in the laboratory and found that the particles triggered inflammation and oxidative stress. The microplastics also weakened the protective barrier function of lung tissue by depleting key structural proteins. The study suggests that inhaling microplastics may increase the risk of respiratory problems by damaging the lung's natural defenses.
Size- and polymer-dependent toxicity of amorphous environmentally relevant micro- and nanoplastics in human bronchial epithelial cells
This study examined how the size and type of plastic particles affect their toxicity to human lung cells. Researchers tested environmentally relevant micro- and nanoplastics with irregular shapes, rather than the uniform spheres typically used in lab studies, to better mimic real-world exposure. The findings contribute to a growing understanding that particle size and polymer composition both matter when assessing the potential health risks of inhaling airborne plastic particles.
Effects of secondary microplastic on the respiratory system of BALB/c mice
Researchers exposed BALB/c mice to secondary microplastics derived from environmentally weathered plastic and assessed respiratory system effects. Secondary MPs caused greater pulmonary inflammation and oxidative stress than virgin particles, suggesting that real-world aged plastics carry higher respiratory toxicity risks than pristine particles used in most laboratory studies.
Repeated inhalation exposure to polystyrene nanoplastics induced sustained pulmonary injury and fibrosis in mice.
Scientists exposed mice to tiny plastic particles found in air pollution and discovered these particles caused serious lung damage and scarring that didn't heal even weeks after exposure stopped. The smallest plastic particles were the most harmful, spreading from the lungs to other organs like the heart and liver. This research suggests that breathing in nanoplastics from everyday sources like car tire wear and plastic waste could pose long-term risks to human lung health.
A Review on Polypropylene Microplastics and Respiratory Toxicity
This review of existing research shows that tiny plastic particles from polypropylene (a common plastic used in food containers and clothing) are now found in the air we breathe and even in human lung tissue. When these microplastics get into our lungs, they can cause inflammation and damage that may lead to breathing problems and other health issues. The findings suggest we need to better understand and reduce our exposure to these plastic particles in our daily environment.
Investigation of pulmonary inflammatory responses following intratracheal instillation of and inhalation exposure to polypropylene microplastics
Rats exposed to polypropylene microplastics through both inhalation and direct lung delivery developed inflammatory responses in their lungs, including increased immune cells and tissue changes. Even at relatively low concentrations, the microplastics triggered pulmonary inflammation, supporting concerns that breathing in airborne microplastics could contribute to respiratory health problems in humans.
Fabrication of microplastic and nanoplastic particles and fibres for use in pulmonary toxicity studies
Researchers developed fabrication methods to produce micro- and nanoplastics from three environmentally relevant polymers (polyamide, polypropylene, and PET) in both particle and fiber shapes, addressing a critical gap in pulmonary toxicity research where most studies use only polystyrene spheres.
Detrimental effects of microplastic exposure on normal and asthmatic pulmonary physiology
Researchers exposed both healthy and asthmatic mice to airborne microplastics and found significant lung inflammation, immune activation, and increased mucus production in both groups. Microplastic particles were taken up by immune cells called macrophages, and gene analysis revealed changes in immune response, cellular stress, and cell death pathways. The study suggests that inhaling microplastics may worsen respiratory health in both normal and vulnerable populations.
Fabrication of microplastic and nanoplastic particles and fibres for use in pulmonary toxicity studies
Researchers developed methods to fabricate polyamide, polystyrene, and polyethylene terephthalate micro/nanoplastics in particle and fiber forms of respirable dimensions, addressing the limitation that most pulmonary toxicity studies have used only commercially available polystyrene spheres.
Sub-acute polyethylene microplastic inhalation exposure induced pulmonary toxicity in wistar rats through inflammation and oxidative stress
Researchers exposed rats to airborne polyethylene microplastics through inhalation for 28 days and found significant signs of lung damage. The exposed animals showed increased inflammation markers, elevated oxidative stress, and tissue changes in the lungs compared to controls. The study provides evidence that breathing in microplastic particles from degraded plastic bags and bottles may cause pulmonary toxicity.
Influence of the polymer type on the impact of microplastic particles
Researchers compared the cellular effects of polystyrene, polyethylene, PVC, and PLA microparticles on murine macrophages and epithelial cells, assessing uptake and cytotoxicity. All polymer types were ingested by macrophages, but the degree of cytotoxicity varied by polymer composition.
Fabrication of microplastic and nanoplastic particles and fibres for use in pulmonary toxicity studies
Researchers developed fabrication methods for polyamide, polystyrene, and polyethylene terephthalate micro/nanoplastics in both particle and fiber forms, producing respirable-sized test materials with verified chemical purity for use in more environmentally realistic lung toxicity studies.
Size-Dependent PulmonaryToxicity and Whole-Body Distributionof Inhaled Micro/Nanoplastic Particles in Male Mice from Chronic Exposure
Researchers used a whole-body inhalation exposure system to chronically expose male mice to polystyrene micro- and nanoplastics at environmental concentrations and tracked particle distribution and lung toxicity. Nanoplastics (80 nm) showed greater tissue transport than microplastics (1 µm), with highest accumulation in lungs followed by blood and spleen, and both sizes disrupted oxidative balance and antioxidant defenses.
Airborne polystyrene microplastics and nanoplastics induce nasal and lung microbial dysbiosis in mice
Researchers found that airborne polystyrene microplastics and nanoplastics can induce microbial dysbiosis in the nasal passages and lungs of mice. The study showed that both micro- and nanoplastics altered airway microbiota composition, with microplastics having a stronger influence on lung bacterial communities, suggesting that inhaled plastic particles may disrupt respiratory microbial balance.
Detection and Analysis of Microplastics in Human Sputum
Researchers analyzed sputum (mucus from the lungs) from 22 patients with respiratory diseases and found microplastics in every single sample, identifying 21 different plastic types. Polyurethane was the most common type detected, and most particles were smaller than 500 micrometers. This study provides direct evidence that humans are inhaling microplastics, with factors like smoking and medical procedures increasing the amount found in the respiratory tract.