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20 resultsShowing papers similar to Chemoprophylaxis of precancerous lesions in patients who are at a high risk of developing colorectal cancer (Review)
ClearRole of dietary nutrients and metabolism in colorectal cancer.
This review examines how dietary nutrients including glucose, amino acids, lipids, vitamins, and prebiotics may influence colorectal cancer risk and progression. The study discusses metabolic interactions between tumor cells, the tumor microenvironment, and gut microbiota, suggesting that nutritional factors play a meaningful role in shaping these complex biological processes.
CHEMOPREVENTIVE POTENTIAL OF ALCOHOLIC EXTRACT OF A POLYHERBAL ( Phyllanthus amarus, Euphorbia hirta and Azadirachta indica) RECIPE AGAINST BENZO(a)PYRENE INDUCED LUNG CARCINOGENESIS IN ALBINO MICE
Researchers assessed the chemopreventive potential of an alcoholic extract of a polyherbal preparation including Phyllanthus amarus in a precancerous lesion model, measuring effects on biomarkers of oxidative stress and inflammation. The herbal extract reduced key biomarkers compared to untreated controls, supporting further investigation of plant-derived compounds as adjuncts in cancer chemoprevention.
The Influence of Ultra-Processed Food on Colorectal Cancer: A Systematic Review
This systematic review of 24 studies found an association between diets high in ultra-processed foods and increased colorectal cancer incidence. The harmful effects are driven by high levels of sugar, fat, red meat, and additives in these foods, compounded by sedentary lifestyles and obesity.
Erchen Decoction Alleviates High-Fat Diet + AOM/DSS-Induced CRC by Ameliorating Cholesterol-Bile Acid Metabolism Disorder through Regulating FXR and the Gut Microbiota
Researchers found that Erchen Decoction, a traditional Chinese medicine formula, alleviates colorectal cancer progression in a high-fat diet mouse model by correcting cholesterol-bile acid metabolism disorders through modulation of FXR signaling and gut microbiota composition.
Uncovering the Anticancer Potential of Polydatin: A Mechanistic Insight
This review examines the anticancer mechanisms of polydatin, a natural stilbenoid compound, detailing its ability to inhibit tumor growth through antioxidant, anti-inflammatory, and apoptotic pathways across multiple cancer types.
The Potential Role and Effective Components of Sanyeqing as the Potential Therapeutic Candidates for IBD and CRC
This review examines the phytochemical constituents of Sanyeqing (a traditional medicinal plant) and their therapeutic potential for inflammatory bowel disease and colorectal cancer, identifying anti-inflammatory and anti-tumor mechanisms that could complement conventional treatments.
Bioactive compounds as potential alternative treatments to prevent cancer therapy-induced male infertility
This review examines bioactive compounds like curcumin and resveratrol as potential non-invasive approaches to help preserve male fertility during cancer treatment. Researchers summarize evidence that these natural compounds may offer chemo-protective effects at the testicular level without the cost and invasiveness of conventional fertility preservation methods. The study suggests that nutritional therapies could complement existing strategies, particularly for younger patients where sperm cryopreservation is not feasible.
Cancer and Food-Related Risks: A Review
This review examines the relationship between diet, food-related environmental exposures, and cancer risk, covering evidence for carcinogenic dietary patterns, contaminants in food including persistent organic pollutants and heavy metals, and the emerging concern of microplastics as potential carcinogens. The authors emphasize that dietary risk is multi-factorial and that improving food safety standards remains a key prevention lever.
The clinical relevance of microplastic exposure on colorectal cancer: A systematic review
This systematic review of four studies found that microplastic accumulation in colorectal cancer tissue (25.9-32.2 particles/g) was significantly higher than in healthy controls, with polyamide, polycarbonate, and polypropylene as the most common polymers detected. While a causal relationship has not been established, the evidence points to microplastics as a potential environmental factor in colorectal cancer development.
Associations between microplastics in human feces and colorectal cancer risk
In a study of 258 colorectal cancer patients and 493 healthy controls, researchers found significantly higher levels of microplastics in the stool of cancer patients, with those in the highest exposure group having 11 times the odds of colorectal cancer. This is one of the first studies in humans to provide epidemiological evidence of a potential link between microplastic exposure and cancer risk, though more research is needed to determine if the relationship is causal.
Invisible invaders: unveiling the carcinogenic threat of microplastics and nanoplastics in colorectal cancer-a systematic review
This systematic review examines the potential link between microplastics and nanoplastics and colorectal cancer. The research highlights how these tiny particles may contribute to cancer development through mechanisms like chronic inflammation and cellular damage in the gut. While more studies are needed, the findings raise important questions about the long-term consequences of ingesting plastic particles.
The incidence of early onset colorectal cancer in Aotearoa New Zealand: 2000–2020
Researchers analyzed colorectal cancer trends in New Zealand from 2000 to 2020, finding that while overall rates declined slightly, early-onset cases (in younger adults) are rising — and rising faster among Maori — suggesting environmental or lifestyle factors, including dietary contaminants, may be contributing to this shift.
Association between Cervical Cancer and Dietary Patterns in Colombia
This ecological study examined dietary patterns in relation to cervical cancer risk in Colombia, identifying associations between specific food consumption patterns and cervical cancer incidence.
Why Is Colorectal Cancer Occurring Earlier? Metabolic Dysfunction, Underrecognized Carcinogens, and Emerging Controversies
Researchers reviewed the rising incidence of early-onset colorectal cancer in people under 50, synthesizing epidemiological, molecular, and multi-omics evidence that implicates metabolic dysfunction, accelerated epigenetic aging, gut microbiome dysbiosis, and modern environmental exposures including micro- and nanoplastics as converging contributors to this trend.
Project MEPROT: Shaping the Future of Early Onset Colorectal Cancer Prevention
This roadmap paper reviews the rising rates of early onset colorectal cancer in people under 50 and proposes a transdisciplinary research framework called Project MEPROT to accelerate the discovery of causal risk factors, including early-life and gut microbial exposures. The author highlights critical gaps in understanding how lifestyle, environmental, and microbiome-related factors contribute to cancer development at younger ages. The study calls for integrating population science, mechanistic research, and behavioral studies to develop effective prevention strategies.
A review on health benefits of marine based neutraceuticals on pancreatic cancer
This review examined health benefits of marine-based nutraceuticals for pancreatic cancer prevention and treatment, finding that bioactive compounds from marine organisms show anti-inflammatory, antioxidant, and antitumor properties with potential to complement therapies for this highly treatment-resistant malignancy.
Orally Ingested Micro- and Nano-Plastics: A Hidden Driver of Inflammatory Bowel Disease and Colorectal Cancer.
This review synthesizes evidence linking ingested micro- and nano-plastics to inflammatory bowel disease and colorectal cancer risk, proposing that microplastics act as a hidden driver of gut inflammation in vulnerable populations. The authors argue that intestinal accumulation of microplastics triggers immune and oxidative stress pathways that contribute to disease progression.
Microplastics and Colorectal Cancer: Presence in Human Colorectal Tissues and Associations with Tumor Biology- A Systematic Review
This review of 13 studies found that tiny plastic particles called microplastics are present in human colon tissues, with higher amounts found in cancerous tumors compared to healthy tissue. The research suggests these plastic particles may contribute to colon cancer development by causing inflammation and creating conditions that help tumors grow. While more research is needed to prove a direct cause-and-effect relationship, this highlights growing concerns about how plastic pollution in our environment and food supply might affect human health.
Considering the Importance of Medicinal Plants and Natural Products and Their Mechanisms of Action for Treatment of Gastrointestinal Disorders
This bibliometric analysis of over a thousand articles reviewed medicinal plants and natural products for treating gastrointestinal disorders, highlighting their anti-inflammatory, antioxidant, and gut-protective mechanisms. While not focused on microplastics, the gut-protective properties of certain natural compounds are relevant to understanding how to mitigate gastrointestinal damage from environmental contaminants.
Bioactive Compounds and Their Derivatives: An Insight into Prospective Phytotherapeutic Approach against Alzheimer’s Disease
Researchers reviewed natural bioactive compounds from plant sources for their potential neuroprotective effects related to Alzheimer's disease. The study highlights how these compounds may modulate molecular mechanisms involved in disease development, while noting challenges such as limited bioavailability and blood-brain barrier permeability.