We can't find the internet
Attempting to reconnect
Something went wrong!
Hang in there while we get back on track
Papers
61,005 resultsShowing papers similar to Transcriptomic Analysis Reveals the Flavonoid Biosynthesis Pathway Involved in Rhizome Development in Polygonatum cyrtonema Hua
ClearComprehensive transcriptomic and metabolomic analyses of one-year-old and two-year-old Polygonatum cyrtonema Hua
Researchers compared transcriptomic and metabolomic profiles of one-year-old and two-year-old organisms to understand how aging alters gene expression and metabolic pathways, identifying age-associated changes in stress response, immune function, and energy metabolism. The multi-omics approach revealed coordinated shifts across molecular levels that provide a baseline for understanding age-related physiological change.
Sakuranetin: A multifaceted study from plant resistance to pharmacological activity
This review synthesized 15 years of research on sakuranetin, a plant flavonoid, covering its biosynthesis, role in plant stress resistance, and pharmacological activities including anti-inflammatory, antiviral, and anticancer properties.
The Traditional Chinese Medicine in Treating Diabetic Nephropathy: A Bibliometric Analysis
This bibliometric analysis reviews research trends on Traditional Chinese Medicine for treating diabetic nephropathy. The study identifies key research hotspots including the clinical efficacy of herbal treatments and their pharmacological mechanisms, with improving oxidative stress and regulating gut microbiota highlighted as promising directions for future investigation.
Integration of transcriptomics and metabolomics reveals the mechanism of Lycium barbarum polysaccharides inhibited MCF-7 cell proliferation
Researchers used transcriptomics and metabolomics to investigate how Lycium barbarum polysaccharides inhibit MCF-7 breast cancer cell proliferation, identifying the molecular mechanisms and signaling pathways responsible for the compound's anticancer activity at an optimal dose of 8 mg/mL.
Preparation of Polysaccharides from Qifuyin and Investigation of Their Anti-Oxidant and Regenerative Effects Based on Planaria
Researchers extracted polysaccharides from the traditional Chinese medicine formula Qifuyin using hydrothermal methods, achieving 29.9% yield and 70.1% purity, and investigated their antioxidant and regenerative effects using planaria as a model organism.
Exogenous ethephon treatment on the biosynthesis and accumulation of astragaloside IV in Astragalus membranaceus Bge. var. mongholicus (Bge.) Hsiao
Researchers investigated how exogenous ethephon (an ethylene-releasing compound) affects the biosynthesis and accumulation of astragaloside IV in hydroponically cultivated Astragalus membranaceus, measuring both content and gene expression changes to understand how ethylene signaling regulates this key secondary metabolite.
Table1_Identifying of Anti-Thrombin Active Components From Curcumae Rhizoma by Affinity-Ultrafiltration Coupled With UPLC-Q-Exactive Orbitrap/MS.DOCX
This supplementary data file accompanies a study screening herbal extracts from Curcuma for compounds that inhibit the clotting enzyme thrombin, using liquid chromatography-mass spectrometry. The research identifies natural plant compounds with potential anticoagulant properties from traditional medicinal plants.
Mechanisms for iron oxide nanoparticle alleviation of nanoplastic-induced stress in Perilla frutescens revealed by integrated physiological and transcriptomic analysis
Researchers found that iron oxide nanoparticles (IONPs) added to soil reduced polystyrene nanoplastic uptake in Perilla frutescens plants by 24–46%, improved plant height and biomass by 20–34%, and mitigated nanoplastic-induced oxidative stress by upregulating photosynthesis and flavonoid biosynthesis genes.
Transcriptome Analysis Reveals the Genes Involved in Bifidobacterium Longum FGSZY16M3 Biofilm Formation
Scientists analyzed gene expression in a beneficial gut bacterium during biofilm formation, identifying key genetic networks involved. This microbiome research is relevant context for understanding how microplastics, which can disrupt gut bacterial communities, may affect the beneficial bacteria that protect digestive health.
The Essential Oil from Conyza bonariensis (L.) Cronquist (Asteraceae) Exerts an In Vitro Antimelanoma Effect by Inducing Apoptosis and Modulating the MAPKs, NF-κB, and PKB/AKT Signaling Pathways
Researchers investigated the anticancer potential of an essential oil extracted from Conyza bonariensis against melanoma cells in laboratory experiments. They found that the oil's major compound interacted with key signaling pathways involved in cell survival and induced programmed cell death in melanoma cells. The study suggests this plant-derived compound may warrant further investigation as a potential source of anti-melanoma agents.
Use of untargeted metabolomics to profile the foliar metabolome of Mitragyna speciosa under varying light and water conditions
Researchers used untargeted metabolomics to profile how light intensity and water availability shape the foliar chemistry of kratom seedlings, finding that high light reduced nitrogen-based alkaloids while increasing photoprotective compounds, and that low light combined with low water triggered an antioxidant stress response.
Integrated metabolomics and transcriptomics reveal the role of calcium sugar alcohol in the regulation of phenolic acid biosynthesis in Torreya grandis nuts
Integrated metabolomics and transcriptomics analysis of Torreya grandis nuts revealed a new regulatory module—Ca2+-AP2-HCT—that links calcium-sugar alcohol signaling to phenolic acid biosynthesis, expanding understanding of how calcium fertilizers influence plant secondary metabolism.
Mechanism of P-Hydroxy Benzyl Alcohol Against Cerebral Ischemia Based on Metabonomics Analysis
Researchers investigated how p-hydroxybenzyl alcohol, an active compound from the traditional medicinal plant Gastrodia elata, protects against brain damage caused by reduced blood flow. Using metabolomics in cell and rat models, they identified that the compound works by improving mitochondrial function and reducing excessive autophagy through a specific signaling pathway. The study provides new molecular targets that could inform future treatments for cerebral ischemia.
Bioactive Compounds and Their Derivatives: An Insight into Prospective Phytotherapeutic Approach against Alzheimer’s Disease
Researchers reviewed natural bioactive compounds from plant sources for their potential neuroprotective effects related to Alzheimer's disease. The study highlights how these compounds may modulate molecular mechanisms involved in disease development, while noting challenges such as limited bioavailability and blood-brain barrier permeability.
Comparative Transcriptome Combined with Morphophysiological Analyses Revealed Carotenoid Biosynthesis for Differential Chilling Tolerance in Two Contrasting Rice (Oryza sativa L.) Genotypes
Researchers used comparative transcriptomics to find that carotenoid biosynthesis is a critical pathway for cold tolerance in rice, with cold-tolerant varieties showing higher carotenoid gene expression and pigment accumulation that protects chloroplasts during chilling stress. This study focuses on plant biology and crop science with no direct connection to microplastic research.
Uncovering the Anticancer Potential of Polydatin: A Mechanistic Insight
This review examines the anticancer mechanisms of polydatin, a natural stilbenoid compound, detailing its ability to inhibit tumor growth through antioxidant, anti-inflammatory, and apoptotic pathways across multiple cancer types.
Metabolism and Transcriptome Stress in Diatom Phaeodactylum tricornutum for Value‐Added Products
Researchers investigated how microplastic exposure acts as an environmental stressor on the marine diatom Phaeodactylum tricornutum, examining transcriptomic and metabolic responses including upregulation of genes involved in lipid and fucoxanthin biosynthesis that could be leveraged for value-added bioproduct applications.
Potential application of traditional Chinese medicine in cerebral ischemia—Focusing on ferroptosis
This review examined evidence for traditional Chinese medicine compounds in treating cerebral ischemia by targeting ferroptosis, an iron-dependent form of regulated cell death. Multiple TCM-derived compounds including flavonoids and alkaloids showed neuroprotective effects through ferroptosis pathway inhibition in experimental ischemia models.
Sciadopitysin attenuates paraquat induced renal toxicity by modulating Nrf2/Keap-1 pathway in male albino rats
Researchers investigated whether the plant compound sciadopitysin could protect against kidney damage caused by the herbicide paraquat in rats. They found that sciadopitysin significantly reduced oxidative stress and inflammation in the kidneys by activating the Nrf2/Keap-1 protective pathway. The study suggests that natural biflavonoid compounds may help mitigate organ damage from toxic environmental chemical exposures.
Exposure to polyethylene terephthalate microplastics induces reprogramming of flavonoids metabolism and gene regulatory networks in Capsicum annuum
Researchers exposed pepper seedlings to PET microplastics and found that the particles significantly disrupted the plants' production of flavonoids, which are beneficial compounds that protect both the plant and human consumers. The microplastics altered gene activity in pathways responsible for flavonoid production, reducing the nutritional quality of the peppers. This suggests that microplastic-contaminated soil could lower the health benefits of vegetables people eat, even when the plants appear to grow normally.
[Screening of quality markers and activity verification of Glycyrrhizae Radix et Rhizoma based on small molecule compound-protein interaction].
Researchers screened 27 chemical compounds in licorice root (Glycyrrhizae Radix) to identify quality markers by measuring how strongly each compound binds to mouse organ proteins. Seven active components were identified, and their anti-inflammatory and antioxidant properties were confirmed in a cell model where macrophages were stressed using microplastics.
Comparative Transcriptome Combined with Morphophysiological Analyses Revealed Carotenoid Biosynthesis for Differential Chilling Tolerance in Two Contrasting Rice (Oryza sativa L.) Genotypes
This paper is not about microplastics; it uses comparative transcriptomics and physiological analysis to investigate how two rice cultivars differ in their tolerance to cold-stress-induced leaf chlorosis.
Beneficial effect of Xuebijing against Pseudomonas aeruginosa infection in Caenorhabditis elegans
Researchers found that the traditional Chinese medicine formulation Xuebijing protected Caenorhabditis elegans against Pseudomonas aeruginosa infection by enhancing immune pathways and reducing bacterial colonization, providing mechanistic insight into its clinical use for treating sepsis.
Relationship between Phenotypes and Chemical Profiling of Boesenbergia rotunda Collected from Different Habitats of Northern Thailand
This is a plant science study on the morphological, genetic, and phytochemical diversity of fingerroot (Boesenbergia rotunda) landraces from Northern Thailand; it is not a microplastics research paper.