Papers

61,005 results
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Article Tier 2

Nanoplastics in the Environment and the Effects on the Zebrafish

This study reviewed the effects of nanoplastic exposure on zebrafish, covering how these tiny particles affect development, organ function, behavior, and reproductive success. Zebrafish are a widely used model organism for toxicology, and findings in this species provide insight into potential effects in other vertebrates including humans.

2019 American Journal of Engineering and Applied Sciences 2 citations
Article Tier 2

From particle size to brain function: a zebrafish-based review of micro/nanoplastic-induced neurobehavioral toxicity and mechanistic pathways

This review uses zebrafish as a model to examine how micro- and nanoplastics cause neurobehavioral toxicity, linking particle size to brain function disruption. Researchers summarize evidence that these plastic particles impair fish behavior and cause molecular-level damage in the nervous system. The findings highlight the growing concern that micro- and nanoplastics are emerging neurotoxicants in aquatic environments.

2025 Environmental Science Nano 3 citations
Article Tier 2

O Modelo Zebrafish e sua Contribuição ao Meio Ambiente

This Brazilian review examined zebrafish as a model organism for testing water quality and the toxicity of micropollutants including microplastics in wastewater. Zebrafish are increasingly used as a standard test system for evaluating the biological effects of microplastic exposure because their genetics and physiology closely mirror human responses.

2021
Article Tier 2

Are Zebrafish Affected by Tiny Plastics in Our Environment?

This article, written for a general audience, explains how polystyrene nanoplastics added to zebrafish egg water penetrate multiple organs and alter swimming behavior and gene expression in developing fish. The findings illustrate why zebrafish are a valuable model for understanding how environmental nanoplastics may affect vertebrate health.

2025 Frontiers for Young Minds
Article Tier 2

Zebrafish Insights into Nanomaterial Toxicity: A Focused Exploration on Metallic, Metal Oxide, Semiconductor, and Mixed-Metal Nanoparticles

This review summarizes research on how various nanomaterials, including nano-sized plastics, affect zebrafish, which are commonly used as stand-ins for studying human health effects. Exposure to nanomaterials caused developmental defects, organ damage, behavioral changes, and reproductive problems in zebrafish. These findings help scientists understand the potential health risks of nanomaterial exposure to humans and the environment.

2024 International Journal of Molecular Sciences 35 citations
Article Tier 2

Behavioral Studies of Zebrafish Reveal a New Perspective on the Reproductive Toxicity of Micro- and Nanoplastics

This review summarizes existing research on how micro- and nanoplastics affect the behavior and reproductive health of zebrafish, a common lab model for studying human biology. The findings suggest that tiny plastic particles can disrupt reproductive behavior and act as hormone-like chemicals, and that behavioral changes in fish may serve as early warning signs of reproductive harm that could be relevant to understanding human health risks.

2024 Toxics 34 citations
Article Tier 2

SUCUL EKOSiSTEMDE MiKRO VE NANOPLASTiKLER / MICRO AND NANOPLASTICS IN AQUATIC ECOSYSTEM

This Turkish-language review covers micro- and nanoplastics in aquatic ecosystems, examining their sources, distribution, and toxic effects on aquatic organisms. Evidence suggests these tiny particles can cross intestinal walls and even breach the blood-brain barrier, posing systemic health risks.

2019 Türk Bilimsel Derlemeler Dergisi
Article Tier 2

Effects of Microplastics and Nanoplastics on Neurodevelopment and Neurodegeneration in Zebrafish

This review covers how micro- and nanoplastic (MNP) exposure affects neurodevelopment and neurodegeneration in zebrafish, summarising evidence on impaired neurodevelopment, behavioural changes, and markers of neurodegeneration from studies using various polymer types and exposure routes. It frames zebrafish as a key model for understanding MNP neurotoxicity.

2025
Article Tier 2

Zebrafish: An emerging model to study microplastic and nanoplastic toxicity

This review highlights zebrafish as an increasingly valuable model organism for studying the toxic effects of micro- and nanoplastics due to their transparent embryos, genetic similarity to humans, and ease of laboratory use. Researchers summarized existing zebrafish studies showing that plastic particles can cross biological barriers and accumulate in tissues, causing various toxic effects. The study positions zebrafish research as a key tool for advancing our understanding of how plastic particle exposure affects living organisms.

2020 The Science of The Total Environment 434 citations
Article Tier 2

Comprehensive review of ecological risks and toxicity mechanisms of microplastics in freshwater: Focus on zebrafish as a model organism

This comprehensive review examines how microplastics affect zebrafish, a widely used laboratory model, covering impacts on the gut, liver, reproductive system, nervous system, and immune function. Researchers found that microplastics can cause oxidative stress, inflammation, and disruption of gut bacteria across multiple organ systems. The review highlights that zebrafish studies provide valuable insights into the biological mechanisms by which microplastics may affect freshwater organisms and, potentially, human health.

2025 Aquatic Toxicology 4 citations
Article Tier 2

In vivo biotoxicological assessment of nanoplastics and microplastics predicted using the zebrafish model

This review summarises zebrafish studies on the toxicity of nanoplastics and microplastics, covering developmental, reproductive, neurological, and organ-level effects. It discusses how findings in this widely used model organism may predict human health outcomes and calls for standardised exposure protocols.

2025 PeerJ
Article Tier 2

Research progress of model animal zebrafish in toxicity evaluation of microplastics

This review examines the use of zebrafish as a model organism for evaluating the toxicity of microplastics, synthesizing research on how microplastic exposure affects development, reproduction, and physiological function in this well-established vertebrate model. The authors highlight zebrafish as a particularly valuable system for mechanistic toxicology studies given its genetic tractability and the breadth of endpoints assessable across life stages.

2022 SHILAP Revista de lepidopterología 1 citations
Article Tier 2

Nanoplastics Cause Neurobehavioral Impairments, Reproductive and Oxidative Damages, and Biomarker Responses in Zebrafish: Throwing up Alarms of Wide Spread Health Risk of Exposure

Researchers exposed adult zebrafish to polystyrene nanoplastics and found that the particles accumulated in the brain, liver, intestine, and gonads, causing significant behavioral and physiological changes. The fish showed disrupted energy metabolism, oxidative stress, and altered locomotion, aggression, and predator avoidance behaviors. The findings raise concerns about the widespread health risks of nanoplastic exposure, as these particles are small enough to cross biological membranes.

2020 International Journal of Molecular Sciences 410 citations
Article Tier 2

Microplastics in Limnic Ecosystems - Investigation of Biological Fate and Effects of Microplastic Particles and Associated Contaminants in Zebrafish (Danio rerio)-

This doctoral thesis investigated how microplastics and their associated chemical contaminants affect zebrafish (Danio rerio) in freshwater environments, including ingestion, tissue accumulation, and toxicological effects. The research demonstrates that microplastics can act as vectors for pollutants like pesticides and pharmaceuticals, compounding their harmful effects on aquatic organisms.

2020 heiDOK (Heidelberg University) 5 citations
Article Tier 2

Research Progress of Zebrafish Model in Aquatic Ecotoxicology

This review examines how zebrafish are used as model organisms to study the toxic effects of environmental pollutants in water, including microplastics. Zebrafish are ideal because they reproduce quickly, are inexpensive to maintain, and allow researchers to study effects at the genetic, cellular, and whole-organism level. The paper provides a reference guide for scientists choosing model animals for aquatic toxicology research.

2023 Water 48 citations
Article Tier 2

Study of the effects of nanoplastics ingestion in a freshwater fish ( Danio rerio )

Researchers exposed zebrafish to polystyrene nanoplastics and found evidence of intestinal damage, oxidative stress, and behavioral changes. The study adds to growing evidence that nanoplastics in freshwater environments can harm fish health, with potential implications for the health of ecosystems and fish-eating humans.

2021 Annals of Medicine 4 citations
Review Tier 2

Advances of microplastics ingestion on the morphological and behavioral conditions of model zebrafish: A review

This review summarizes research on how microplastic ingestion affects zebrafish, a popular lab animal that shares genetic similarities with humans. Studies show that microplastics cause a range of harmful effects in zebrafish, including abnormal behavior, oxidative stress, immune disruption, and reproductive problems, with smaller particles and higher concentrations causing the most damage. Since zebrafish are used as a model for human health, these findings raise concerns about what similar exposure levels could mean for people.

2024 Aquatic Toxicology 17 citations
Article Tier 2

Zebrafish as Model Organism in Aquatic Ecotoxicology: Current Trends and Future Perspectives

This review assessed zebrafish as model organisms for aquatic ecotoxicology, summarizing current trends and future directions in using Danio rerio to study the effects of environmental pollutants including microplastics. The authors highlight the zebrafish model's utility for integrating molecular, cellular, and whole-organism responses.

2023 IntechOpen eBooks 4 citations
Article Tier 2

Uptake Routes and Biodistribution of Polystyrene Nanoplastics on Zebrafish Larvae and Toxic Effects on Development

Researchers exposed zebrafish embryos and larvae to amino-modified polystyrene nanoplastics to study uptake routes and biodistribution. The study found that nanoplastics accumulated in target organs and caused toxic developmental effects, providing evidence that these tiny plastic fragments can penetrate biological barriers and interfere with normal development in aquatic organisms.

2023 Fishes 17 citations
Article Tier 2

Impacts of Environmental Concentrations of Nanoplastics on Zebrafish Neurobehavior and Reproductive Toxicity

Researchers exposed zebrafish to environmentally realistic levels of polystyrene nanoplastics and found they caused both brain and reproductive damage. The nanoplastics disrupted neurotransmitter signaling and impaired the hormonal pathway connecting the brain to reproductive organs, with different effects in males and females. These findings suggest that even low-level nanoplastic exposure could affect both brain function and fertility in aquatic life that humans may consume.

2024 Toxics 16 citations
Article Tier 2

A review on the impacts of nanomaterials on neuromodulation and neurological dysfunction using a zebrafish animal model

This review assessed zebrafish as a model for studying nanomaterial neurotoxicity, summarizing evidence that various engineered nanoparticles including those associated with plastics can impair zebrafish neural development, behavior, and neurotransmitter systems. The authors highlighted zebrafish as particularly useful for rapid in vivo screening of nanomaterial neurological effects.

2022 Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology 15 citations
Article Tier 2

Zebrafish embryos as a biological model to study the effects of nanoplastics

This study used zebrafish embryos as a model system to investigate the toxic effects of nanoplastics, finding developmental disruptions at concentrations relevant to environmental exposure. Zebrafish embryos are a widely used model because their transparency allows direct visualization of organ development during toxicant exposure.

2019 Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)
Article Tier 2

Size matters: Zebrafish (Danio rerio) as a model to study toxicity of nanoplastics from cells to the whole organism

Researchers used zebrafish as a model organism to study the toxic effects of polystyrene nanoplastics at both cellular and whole-organism levels. They found that smaller nanoplastic particles were taken up more readily by cells and caused greater oxidative stress and developmental abnormalities than larger particles. The study confirms that particle size is a critical determinant of nanoplastic toxicity, with the smallest particles posing the greatest biological risks.

2020 Environmental Pollution 152 citations
Article Tier 2

Influence of nanoparticles of industrial plastics on model fish Danio rerio (Hamilton, 1822)

This study examined the effects of industrial plastic nanoparticles on zebrafish (Danio rerio) at concentrations relevant to natural water bodies, focusing on their ability to penetrate living cells by endocytosis and cause toxic effects in aquatic organisms.

2024 Водные биоресурсы и среда обитания