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61,005 resultsShowing papers similar to Effects of food contact material-related nanoplastics on 3T3-L1 cell uptake and lipid metabolism
ClearImpact of polyethylene terephthalate and polylactic acid nanoplastics on cellular uptake and lipid metabolism in differentiated 3T3-L1 adipocytes
Researchers studied how nanoplastics made from PET (common in bottles) and PLA (a biodegradable plastic) affect fat cells in laboratory cultures, finding that both types were taken up by adipocytes and disrupted lipid metabolism. PET nanoplastics promoted fat accumulation while PLA nanoplastics triggered fat breakdown, suggesting different plastic types may have distinct effects on metabolic processes. The findings indicate that nanoplastics released from everyday items like tea bags could potentially interfere with energy balance in fat tissue.
Dietary exposure to polystyrene nanoplastics impairs fasting-induced lipolysis in adipose tissue from high-fat diet fed mice
Researchers demonstrated that fluorescent polystyrene nanoplastics accumulate in the white adipose tissue of mice and can traffic across adipocyte cells. The study found that dietary exposure to nanoplastics impaired fasting-induced fat breakdown in mice fed a high-fat diet, suggesting that nanoplastics may interfere with lipid metabolism and potentially play a role in obesity progression.
Cellular mechanisms of microplastic and nanoparticle exposure and its relationship with metabolic diseases: Literature review
This literature review examined how microplastic and nanoparticle exposure affects cellular mechanisms related to metabolic disease, finding evidence that these contaminants disrupt insulin signaling, alter lipid metabolism, and may contribute to the development of metabolic syndrome.
Are microplastics in food a risk factor for obesity: Current evidence, mechanistic pathways and emerging health risks associated with human exposure
This review examines the emerging evidence linking microplastic and nanoplastic exposure to metabolic dysfunction and potential obesity risk. Researchers found that these particles have been detected in multiple human tissues and may contribute to inflammation, hormonal disruption, gut microbiome changes, and altered fat cell development. While animal and laboratory studies support a plausible connection, the study notes that direct evidence in humans is still limited and further research is needed.
Oral exposure to nanoplastics altered lipid profiles in mouse intestine
Researchers exposed mice to nanoplastics orally for 14 days and found significant changes in lipid profiles within their intestinal tissue, even without visible tissue damage. The nanoplastics disrupted key fat metabolism pathways and triggered signs of abnormal cellular cleanup processes called autophagy. The study suggests that nanoplastic ingestion may alter how the gut processes fats, with potential implications for metabolic health.
Polystyrene nanoplastics dysregulate lipid metabolism in murine macrophages in vitro
Researchers investigated the effects of polystyrene nanoplastics on immune cell metabolism and found that macrophages exposed to nanoplastics transformed into lipid-laden foam cells. The study suggests that nanoplastic exposure dysregulates lipid metabolism in immune cells, with implications for understanding how these particles may interact with the immune system at the cellular level.
Biological exposure to microplastics and nanoplastics and plastic additives: impairment of glycolipid metabolism and adverse effects on metabolic diseases
This review examines how exposure to micro- and nanoplastics disrupts the body's ability to process sugars and fats, potentially contributing to diabetes, obesity, and atherosclerosis. The plastics cause inflammation and oxidative stress, damage gut bacteria, trigger insulin resistance, and increase fat buildup in the liver. For people who already have metabolic conditions, plastic exposure may make their disease worse.
Mixtures of polystyrene micro and nanoplastics affects fat and glucose metabolism in 3T3-L1 adipocytes and zebrafish larvae
Exposure to a mixture of micro- and nanoplastics increased fat production and impaired the body's ability to use insulin and process sugar in both cell and zebrafish experiments. The plastic mixture triggered inflammation, boosted fat-storing genes, and suppressed insulin signaling pathways. These findings suggest that microplastic exposure could contribute to obesity and type 2 diabetes.
Exposure to polystyrene nanoplastics impairs lipid metabolism in human and murine macrophages in vitro
Researchers exposed human and mouse macrophages to polystyrene nanoplastics and found that the particles disrupted lipid metabolism in these immune cells. The study observed that nanoplastic exposure altered how macrophages process and store fats, which could affect their ability to function properly. These findings suggest that nanoplastic accumulation in immune cells may interfere with normal metabolic processes at the cellular level.
Polystyrene nanoplastics induce glycolipid metabolism disorder via NF-κB and MAPK signaling pathway in mice
Researchers fed mice polystyrene nanoplastics and found that the particles disrupted the animals' ability to regulate blood sugar and fat metabolism. The nanoplastics triggered oxidative stress and inflammation in the liver, activating signaling pathways that led to insulin resistance and abnormal fat accumulation. The study provides evidence that nanoplastic exposure may contribute to metabolic disorders through specific molecular mechanisms involving the NF-kB and MAPK pathways.
Eco-toxicity of nano-plastics and its implication on human metabolism: Current and future perspective
This review examines the sources, bioaccumulation pathways, and potential health effects of nanoplastics on human metabolism. Researchers found that nanoplastics can enter the body primarily through ingestion of contaminated food and packaging, and evidence suggests they may interfere with metabolic pathways and contribute to organ dysfunction. The study highlights that significant knowledge gaps remain in assessing the human health risks of nanoplastic exposure.
Human exposure to micro- and nanoplastics: a mechanistic perspective of health risks associated with metabolic and reproductive functions
This review examines how micro- and nanoplastics enter the human body through food, air, and skin contact, and the mechanisms by which they may disrupt metabolic and reproductive health. Researchers describe how these particles are absorbed through the gut, enter the bloodstream, and accumulate in organs where they can trigger inflammation, oxidative stress, and hormonal disruption. The evidence indicates that micro- and nanoplastics, particularly those carrying endocrine-disrupting chemicals, may pose significant risks to fertility and metabolic function.
Recent insights into uptake, toxicity, and molecular targets of microplastics and nanoplastics relevant to human health impacts
This review summarizes what scientists know about how tiny plastic particles enter the human body and cause harm at the cellular level, including through inflammation, oxidative stress, and disruption of important cell signaling pathways. Americans are estimated to consume tens of thousands to millions of micro- and nanoplastic particles per year, and these particles can penetrate cells and tissues throughout the body.
Untoward Effects of Micro- and Nanoplastics: An Expert Review of Their Biological Impact and Epigenetic Effects
This expert review examined the biological and epigenetic effects of micro- and nanoplastics on living organisms. The study suggests that while intestinal uptake of plastic particles appears relatively low and size-dependent, nanoplastics may dysregulate molecular signaling pathways, alter gut microbiota composition, and induce transgenerational epigenetic changes potentially linked to metabolic disorders.
Polystyrene Nanoplastics Induce Lipid Metabolism Disorder by Activating the PERK-ATF4 Signaling Pathway in Mice
Mice exposed to polystyrene nanoplastics developed abnormal fat buildup in their livers through a specific stress pathway in cells called the endoplasmic reticulum. The nanoplastics activated a signaling chain (PERK-ATF4) that ramped up fat-producing genes, leading to excess fat droplets in liver tissue -- a finding that helps explain how nanoplastic exposure could contribute to liver disease and metabolic problems.
Nano-and Microplastics Migration from Plastic Food Packaging into Milk and Dairy Products: Impact on Nutrient Digestion, Absorption, and Metabolism
This review examined how nano- and microplastics migrate from plastic food packaging into milk and dairy products, discussing their potential impacts on nutrient digestion, absorption, and metabolism in the human body.
Size-Dependent Disruption of Lipid Metabolism by Polystyrene Micro- and Nanoplastics in Caenorhabditis elegans Revealed Through Multi-Omics and Functional Genetic Validation
Researchers used the model organism C. elegans to study how polystyrene particles of different sizes affect lipid metabolism, finding that both 100-nanometer and 1-micrometer particles disrupted fat storage and lipid processing. Multi-omics analysis identified four core genes governing the size-dependent metabolic disruption, and elevated levels of specific lipid metabolites confirmed that microplastics can meaningfully interfere with lipid homeostasis.
Nanoplastic Exposure at Environmental Concentrations Disrupts Hepatic Lipid Metabolism through Oxidative Stress Induction and Endoplasmic Reticulum Homeostasis Perturbation
A study in fish found that nanoplastics at environmentally realistic concentrations accumulated in the liver and disrupted fat metabolism, causing a condition similar to fatty liver disease. Smaller nanoplastics (100 nanometers) caused more severe damage than larger microplastics by disrupting protein processing in cells and triggering oxidative stress. These findings raise concerns that nanoplastics in the environment could affect liver health in fish and potentially in humans who consume contaminated seafood.
[The effect and mechanism of exposure to polystyrene nanoplastics on lipid metabolism in mice liver].
Researchers exposed mice to 20 nm polystyrene nanoplastics and investigated the effects on hepatic lipid metabolism using multi-omics approaches. Nanoplastic exposure disrupted lipid metabolic pathways in the liver, causing significant changes in lipid accumulation and related gene expression, suggesting a mechanism by which nanoplastic ingestion may contribute to metabolic disorders.
Effects of micro- and nanoplastic exposure on macrophages: a review of molecular and cellular mechanisms
This review details how macrophages, key immune cells, respond when they engulf micro- and nanoplastics. The particles trigger inflammatory signaling, damage mitochondria and lysosomes, cause excessive production of harmful reactive oxygen species, and can lead to cell death, while in fat tissue they promote fat buildup and insulin resistance.
Association between exposure to microplastics and lipid disorders: A case-control study
Researchers conducted a case-control study examining the association between internal microplastic exposure and lipid metabolism disorders. The study found that microplastic exposure was significantly associated with lipid disorders, providing novel evidence that microplastics may adversely affect lipid metabolism in humans.
A metabolomics perspective on the effect of environmental micro and nanoplastics on living organisms: A review
This review examines how scientists use metabolomics, the study of small molecules produced by cellular processes, to understand the toxic effects of microplastics and nanoplastics on living organisms. The research shows that these plastic particles disrupt metabolism in consistent ways across species, affecting energy production, fat processing, and amino acid pathways. These shared metabolic disruptions across different organisms suggest that microplastics could cause similar metabolic problems in humans.
Impact of food matrices on the characteristics and cellular toxicities of ingested nanoplastics in a simulated digestive tract
Researchers investigated how different food components affect the toxicity of polystyrene nanoplastics as they pass through a simulated human digestive system. They found that fat molecules helped stabilize and disperse the nanoplastics during digestion, increasing their uptake by intestinal cells and worsening cellular damage. The study suggests that the type of food consumed alongside nanoplastic-contaminated items could significantly influence how much harm the particles cause in the gut.
Polyvinyl chloride nanoplastics induce lipid metabolism reprogramming of macrophages
This study found that polyvinyl chloride nanoplastics trigger lipid metabolism reprogramming in macrophages, promoting foam cell formation through a lipoprotein-mediated pathway, suggesting a potential mechanism linking nanoplastic exposure to cardiovascular disease risk.