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61,005 resultsShowing papers similar to In vivo test of acute exposure of polyethylene microplastics on kidney and liver of Rattus norvegicus Wistar strain rats
ClearAcute Toxicity Assessment of Orally Administered Microplastic Particles in Adult Male Wistar Rats
Researchers gave adult male rats a single oral dose of microplastics made from PET water bottles and found that even this one-time exposure altered markers of liver, heart, and kidney function. Higher doses also reduced food intake and increased signs of oxidative stress, which is cell damage caused by harmful molecules. This study suggests that even brief microplastic exposure could trigger early changes in organ function, raising questions about the cumulative effect of daily human exposure through food and water.
Kidney and Liver Disorders Due to Microplastic Exposure: Chronic in Vivo Study in Male White Rats
Male white rats were chronically exposed to microplastics (particles 5 mm or smaller) to assess kidney and liver toxicity, with exposure resulting from environmental weathering and ultraviolet irradiation of plastic materials. The study found measurable histopathological and biochemical damage in both organs, confirming that long-term microplastic exposure causes organ-level injury in mammals.
Polyethylene microplastics disrupt renal function, mitochondrial bioenergetics, redox homeostasis, and histoarchitecture in Wistar rats
Researchers gave rats polyethylene microplastics orally for 28 days and found dose-dependent kidney damage, including impaired filtration, electrolyte imbalances, and tissue inflammation. The microplastics depleted antioxidant defenses, increased oxidative stress markers, and disrupted mitochondrial energy production in kidney cells, identifying the kidneys as a critical target of microplastic toxicity.
Exploring the Impacts of Polyethylene Microplastics on Rat Liver
Wistar rats exposed to polyethylene microplastics at 0.1–5 mg/kg for 4 weeks showed dose-dependent PE accumulation in liver tissue confirmed by fluorescence microscopy, with histopathological signs of liver injury despite no significant change in body weight.
Renal and Hepatotoxic Effects of Polyethylene Terephthalate Microplastics in Chronically Exposed Albino Rats
Researchers exposed albino rats to different doses of PET microplastics for 90 days and measured kidney and liver function markers. They found that chronic exposure led to significant changes in serum urea, creatinine, and liver enzymes, suggesting potential kidney and liver damage at higher doses. The study also found that water stored in PET containers exposed to sunlight showed similar toxic effects, raising concerns about everyday plastic container use.
Dose‐Dependent Toxicological Effects of Polyvinyl Chloride and Polystyrene Microplastics on Wistar Albino Rats
Researchers fed rats PVC and polystyrene microplastics at different doses for eight weeks and observed significant changes including weight loss, elevated blood glucose, increased cholesterol and liver enzymes, and signs of oxidative stress. The study suggests that oral microplastic exposure at these levels can cause dose-dependent toxicological effects across multiple organ systems in mammals.
Chronic Microplastic Exposure Dose‐Dependently Induces Liver Failure via Oxidative Stress, Inflammation, and Apoptosis in Rats
This animal study found that chronic exposure to polyethylene microplastics caused dose-dependent liver damage in rats over just four weeks. Higher doses led to increased markers of liver injury, oxidative stress, inflammation, and cell death, suggesting that ongoing microplastic ingestion could harm liver health over time.
Microplastic Exposure Impairs Weight Gain, Reproduction, Blood Glucose Levels, and Organ Health in Rats (Rattus norvegicus)
Rats orally exposed to microplastic solutions at 1–10% concentrations over 28 days showed dose-dependent impairment of weight gain, reproductive function, blood glucose regulation, and organ health compared to controls—providing mammalian in vivo evidence that microplastic ingestion causes systemic physiological harm.
Microplastics exposure altered hematological and lipid profiles as well as liver and kidney function parameters in albino rats (Rattus norvegicus)
Researchers fed albino rats different concentrations of microplastics for 28 days and measured changes in blood, liver, kidney, and lipid profiles. They found dose-dependent effects including reduced immune cell counts suggesting immunosuppression, lower red blood cell levels indicating anemia, and altered liver and kidney function markers. The study provides evidence that microplastic ingestion may affect multiple organ systems and blood health in a way that worsens with higher exposure levels.
Early Physiological and Biochemical Responses to Short-Term Oral Exposure to Microplastic Particles in Male Wistar Rats
Scientists fed rats tiny plastic particles from water bottles and found changes in their blood chemistry and drinking habits within just 24 hours, even though the rats appeared healthy on the outside. This study suggests that microplastics—which people consume daily through food and drinks—might start affecting our bodies much faster than previously thought. The research highlights the need to better understand these immediate effects, as they could lead to bigger health problems over time.
The Histopathological and Genetic Effects of Long-Term Treatment with High-Molecular-Weight Polyvinyl Chloride on Various Organs of Young Wistar Rats
Researchers fed young Wistar rats food containing 1% or 2% polyvinyl chloride for eight weeks, finding histopathological damage to the intestines, liver, kidney, and spleen, along with genetic effects including DNA fragmentation, demonstrating organ-level toxicity of chronic PVC microplastic ingestion.
Nanoplastics-induced oxidative stress, antioxidant defense, and physiological response in exposed Wistar albino rats
Researchers orally exposed Wistar rats to polystyrene nanoplastics at multiple doses for five weeks and observed dose-dependent increases in oxidative stress. The study found significant alterations in liver and kidney function markers, disrupted energy metabolism, and changes in antioxidant enzyme activity, suggesting that nanoplastic exposure may affect multiple organ systems in mammals.
Microplastic exposure and its consequences for renal and urinary health: systematic review of in vivo studies
This systematic review examines animal studies on how microplastic exposure affects the kidneys and urinary system. The evidence suggests that microplastics can accumulate in kidney tissue and may cause inflammation and oxidative stress, raising concerns about potential long-term effects on human kidney health as our exposure to these particles continues to grow.
Effects of Orally Ingested Microplastics on the Structure and Function of the Kidneys
This study reviewed the structural and functional effects of orally ingested microplastics on kidney tissue, synthesizing experimental evidence from animal and in vitro studies. Microplastic exposure was consistently associated with kidney histopathology including inflammation and fibrosis, with particle size, shape, and polymer type influencing the severity of renal damage.
Microplastics in motion: Genotoxic and redox imbalance impacts of systemic exposure in a murine model
Researchers injected polyethylene microplastics into mice and found the particles accumulated in the blood, liver, and kidneys, with DNA damage detected in peripheral blood. The study revealed complex organ-specific oxidative and nitrosative stress responses, suggesting that systemic microplastic exposure can trigger genotoxicity and disrupt redox balance in multiple tissues.
Effects of Polystyrene Microplastics on Human Kidney and Liver Cell Morphology, Cellular Proliferation, and Metabolism
Researchers exposed human kidney and liver cells to polystyrene microplastics of different sizes and concentrations to assess their effects on cell health. They found that microplastics altered cell shape, reduced proliferation, and disrupted cellular metabolism, with smaller particles generally causing more damage. The findings suggest that microplastics reaching internal organs could have measurable effects at the cellular level.
The effect of polystyrene foam in different doses on the blood parameters and relative mass of internal organs of white mice
Researchers fed white mice different doses of polystyrene foam over 42 days and found dose-dependent changes in blood biochemical parameters and relative organ masses, providing evidence that ingested microplastics affect metabolism and internal organ function in mammals.
Dose-dependent alteration in hepatic and cerebral glucose metabolism following exposure to polystyrene microplastic in Wistar rats
Researchers exposed Wistar rats to polystyrene microplastics and observed dose-dependent changes in glucose metabolism in both the liver and brain. The study suggests that microplastic exposure may disrupt normal metabolic processes, with higher doses leading to more pronounced alterations in hepatic and cerebral glucose handling.
Polystyrene microplastics induced nephrotoxicity associated with oxidative stress, inflammation, and endoplasmic reticulum stress in juvenile rats
This study found that polystyrene microplastics caused kidney damage in young rats through a combination of oxidative stress, inflammation, and a cellular stress response called endoplasmic reticulum stress. The microplastics also reduced body weight growth and affected multiple organs including the heart and ovaries. These findings suggest that microplastic exposure during development could be particularly harmful to kidney health in young, growing organisms.
Tissue accumulation of microplastics in mice and biomarker responses suggest widespread health risks of exposure
Researchers fed mice polystyrene microplastics of two sizes and tracked where the particles accumulated in the body, finding them in the liver, kidneys, and gut with distribution patterns depending on particle size. Biochemical analysis revealed that microplastic exposure disrupted energy and fat metabolism, caused oxidative stress, and altered markers of neurotoxicity in the blood. The study provides evidence that microplastics can accumulate in mammalian tissues and may pose widespread health risks.
Microplastics and Kidneys: An Update on the Evidence for Deposition of Plastic Microparticles in Human Organs, Tissues and Fluids and Renal Toxicity Concern
This review summarizes the growing evidence that microplastics are found throughout the human body, including in the placenta, lungs, liver, heart, blood, and breast milk. While direct evidence for kidney damage in humans is still lacking, animal studies show that microplastics can cause kidney inflammation, cell death, and oxidative stress. The findings highlight that microplastics are accumulating in virtually every human organ, though the long-term health consequences remain unclear.
Effect of Polystyrene Microplastics Exposure on Blood Parameters in Mice
Researchers exposed mice to polystyrene microplastics in drinking water over four weeks and found increased white blood cell counts, elevated liver enzymes indicating hepatic injury, and altered kidney function markers. The study suggests that subchronic oral microplastic exposure induces inflammatory responses and disrupts liver and kidney function, with no significant recovery observed after a two-week withdrawal period.
Reproductive and metabolic toxic effects of polystyrene microplastics in adult female Wistar rats: a mechanistic study
Researchers gave female rats polystyrene microplastics orally for 45 days and found disruptions to both metabolic and reproductive hormone levels, including increased cholesterol, insulin resistance, and altered sex hormones. The microplastics also caused liver fibrosis and elevated inflammatory markers. The study suggests that chronic microplastic exposure may contribute to metabolic and endocrine disruption in mammals.
Manifestation of polystyrene microplastic accumulation in tissues of vital organs including brain with histological and behaviour analysis on Swiss albino mice
Researchers exposed rats to polystyrene microplastics and examined accumulation in vital organs including the brain, liver, kidney, and gut, finding tissue-specific deposition that was associated with behavioral changes and organ-level pathological effects.