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20 resultsShowing papers similar to Exacerbation of polyethylene microplastics in animal models of DSS-induced colitis through damage to intestinal epithelial cell conjunctions
ClearInfluence of Microplastics on Morphological Manifestations of Experimental Acute Colitis
Researchers fed polystyrene microplastics to mice for six weeks and found that healthy mice developed changes in their colon lining, including altered mucus composition and immune cell populations. When mice with experimentally induced colitis also consumed microplastics, their intestinal inflammation was significantly more severe. The study suggests that microplastic exposure may worsen inflammatory bowel conditions.
Influence of Microplastics on Manifestations of Experimental Chronic Colitis
Researchers studied whether consuming microplastics worsens chronic colon inflammation in mice. While microplastics alone did not cause visible damage to healthy intestines, they significantly increased the severity of colitis symptoms, including more ulcers and greater inflammatory cell infiltration, in mice with pre-existing colon inflammation. The findings suggest that microplastic exposure may be particularly concerning for individuals who already have inflammatory bowel conditions.
An inverted in vitro triple culture model of the healthy and inflamed intestine: Adverse effects of polyethylene particles.
Using a laboratory model of the human intestinal lining, researchers tested how polyethylene microplastics affect intestinal cells and found they disrupted the barrier function of the gut wall. A compromised intestinal barrier allows larger molecules and particles to pass into the body, which could amplify the health effects of microplastic ingestion.
Polyethylene terephthalate microplastics affect gut microbiota distribution and intestinal damage in mice
Mice exposed to PET microplastics, the type commonly found in plastic bottles, developed intestinal inflammation, changes in gut bacteria, and signs of a weakened gut barrier. Even at relatively low doses, the microplastics increased liver stress markers and disrupted the protective mucus layer in the colon, suggesting that everyday PET plastic exposure could contribute to digestive health problems.
Polyvinyl chloride microplastics induced gut barrier dysfunction, microbiota dysbiosis and metabolism disorder in adult mice
Researchers exposed adult mice to PVC microplastics for 60 days and observed significant damage to the intestinal barrier, including reduced mucus production and increased gut permeability. The exposure also caused notable shifts in gut bacteria composition and altered metabolic profiles in ways associated with intestinal injury. These findings suggest that chronic microplastic ingestion may disrupt gut health by weakening the intestinal lining and changing the microbiome.
Polystyrene microplastics aggravate inflammatory damage in mice with intestinal immune imbalance
Researchers found that polystyrene microplastics caused significantly worse inflammatory damage in mice that already had compromised intestinal immune systems compared to healthy mice. The microplastics increased inflammatory markers, disrupted gut bacteria, and caused more severe tissue damage in the vulnerable animals. The study suggests that individuals with pre-existing gut health issues may be more susceptible to the harmful effects of microplastic exposure.
Oral exposure to polyethylene microplastics alters gut morphology, immune response, and microbiota composition in mice
Researchers fed mice polyethylene microplastics of two sizes commonly found in human stool for six weeks and examined the effects on gut health. The study found that microplastic exposure altered gut structure, disrupted immune cell function, changed gene expression related to inflammation and gut barrier integrity, and shifted the composition of gut bacteria. Mice exposed to both sizes simultaneously showed the most severe effects, suggesting that real-world exposure to mixed microplastic sizes may compound the damage.
Polystyrene micro- and nanoplastics aggravates colitis in a mouse model – effects on biodistribution, macrophage polarization, and gut microbiome
Researchers found that polystyrene micro- and nanoplastics aggravated colitis symptoms in a mouse model, increasing gut permeability, inflammatory cytokine levels, and tissue damage compared to controls. The study provides mechanistic evidence linking microplastic exposure to worsening of inflammatory bowel conditions.
Cytotoxicity of UV-degradated polystyrene nanoplastics in co-culture model of inflammatory bowel disease.
Researchers exposed intestinal co-culture models representing inflammatory bowel disease to UV-degraded polystyrene nanoplastics, finding greater cytotoxicity compared to pristine particles. The results suggest that people with IBD may be more vulnerable to nanoplastic-induced gut damage than healthy individuals.
Oral exposure to polyethylene microplastics exacerbates the effects of a Western-style diet on the digestive tract of adult male mice
Researchers investigated how oral exposure to polyethylene microplastics interacts with a Western-style diet to affect the digestive tract of mice over 90 days. The study found that microplastics exacerbated diet-related intestinal disruption, suggesting that dietary context plays an important role in determining the health impact of microplastic ingestion.
Microplastics induced ileum damage: Morphological and immunohistochemical study
Researchers fed mice different concentrations of polyethylene microplastics for 15 days and found significant damage to the small intestine (ileum), including shortened villi, increased mucus-producing cells, and elevated markers of cell death. The damage was dose-dependent, with the highest concentration causing the most severe effects, and some damage persisted even after a 15-day recovery period. This study provides detailed evidence that microplastic ingestion can physically damage the gut lining in mammals.
Exposure to polyethylene microplastics exacerbate inflammatory bowel disease tightly associated with intestinal gut microflora
This study found that polyethylene microplastics, one of the most common types found in everyday products, worsened inflammatory bowel disease symptoms by disrupting the gut microbiome. The microplastics changed the balance of gut bacteria in ways that increased intestinal inflammation. These findings suggest that swallowing microplastics through food and drinks could make existing bowel conditions worse or contribute to gut inflammation in otherwise healthy people.
Microplastics perturb colonic epithelial homeostasis associated with intestinal overproliferation, exacerbating the severity of colitis
Researchers found that microplastic exposure disrupted the balance of cell growth and differentiation in the colon lining of mice, triggering overproliferation of intestinal stem cells through activation of the Notch signaling pathway. While microplastics alone caused only mild inflammation, they significantly worsened the severity of experimentally induced colitis, leading to more severe weight loss, tissue damage, and inflammation. The study suggests that microplastic exposure may increase vulnerability to inflammatory bowel conditions.
Microplastic: A potential threat to human and animal health by interfering with the intestinal barrier function and changing the intestinal microenvironment
This review summarizes current research on how microplastics disrupt the gut environment in both animals and humans, focusing on damage to the intestinal barrier. Studies show that microplastic exposure can cause oxidative damage, inflammation, destruction of the gut lining, thinning of the protective mucus layer, and disruption of beneficial gut bacteria. While direct human evidence is still limited, the growing body of animal research suggests that microplastics could pose a meaningful threat to intestinal health.
Polystyrene micro- and nanoplastics in a colitis mouse model – effects on biodistribution, macrophage polarization, and gut microbiome
Researchers exposed colitis mouse models to polystyrene micro- and nanoplastics to test whether MNP exposure worsens inflammatory bowel disease, finding that MNPs altered biodistribution and exacerbated inflammatory responses in animals with pre-existing gut inflammation.
Polystyrene microplastics exposure increases the disruption of intestinal barrier integrity and gut microbiota homeostasis during obesity and aging
Researchers found that polystyrene microplastic exposure worsened intestinal barrier dysfunction in mice on high-fat diets, with the combination of obesity and microplastic exposure producing greater gut permeability and inflammation than either factor alone, suggesting compounding risks in metabolically vulnerable individuals.
Perturbation of gut microbiota plays an important role in micro/nanoplastics-induced gut barrier dysfunction
Researchers investigated how micro- and nanoplastics disrupt gut barrier function in mice, finding that different surface chemistries caused varying levels of damage. The study suggests that these plastic particles harm the gut by altering the gut microbiome, which then leads to inflammation and weakening of the intestinal barrier that normally keeps harmful substances out of the body.
Microplastic effects on mouse colon in normal and colitis conditions: A literature review
This literature review examined studies on how microplastic exposure affects the mouse colon under both normal and inflammatory conditions. Evidence indicates that microplastics may contribute to intestinal inflammation and could worsen existing colitis. The review highlights the need for further research to better understand how microplastic ingestion may influence gut health in humans.
Polyethylene microplastics affect the distribution of gut microbiota and inflammation development in mice
Researchers fed mice different concentrations of polyethylene microplastics for five weeks and found significant changes in gut bacteria composition and signs of intestinal inflammation. Higher doses increased bacterial diversity and altered the balance of specific bacterial species, while triggering immune responses and inflammation in the colon and duodenum. The study provides evidence that microplastic ingestion can disrupt the gut microbiome and promote intestinal inflammation in mammals.
The enhancement in toxic potency of oxidized functionalized polyethylene-microplastics in mice gut and Caco-2 cells
Researchers found that when polyethylene microplastics undergo oxidation in the environment, they become significantly more toxic to the gut than their unoxidized counterparts. In experiments with mice and human intestinal cells, oxidized microplastics caused more severe intestinal inflammation and disrupted the gut barrier. The study suggests that the environmental weathering of plastic waste may increase its biological harm, which is an important factor often overlooked in toxicity assessments.