We can't find the internet
Attempting to reconnect
Something went wrong!
Hang in there while we get back on track
Papers
20 resultsShowing papers similar to Mechanism of P-Hydroxy Benzyl Alcohol Against Cerebral Ischemia Based on Metabonomics Analysis
ClearPotential application of traditional Chinese medicine in cerebral ischemia—Focusing on ferroptosis
This review examined evidence for traditional Chinese medicine compounds in treating cerebral ischemia by targeting ferroptosis, an iron-dependent form of regulated cell death. Multiple TCM-derived compounds including flavonoids and alkaloids showed neuroprotective effects through ferroptosis pathway inhibition in experimental ischemia models.
Huperzine A ameliorates neurological deficits after spontaneous subarachnoid hemorrhage through endothelial cell pyroptosis inhibition
Researchers investigated how the compound Huperzine A affects brain damage following spontaneous subarachnoid hemorrhage in rats. They found that the treatment reduced blood-brain barrier damage and brain swelling by blocking a type of inflammatory cell death in blood vessel cells. The study suggests that Huperzine A may offer protective benefits for brain health after hemorrhagic stroke through its anti-inflammatory and antioxidant properties.
Bioactive Compounds and Their Derivatives: An Insight into Prospective Phytotherapeutic Approach against Alzheimer’s Disease
Researchers reviewed natural bioactive compounds from plant sources for their potential neuroprotective effects related to Alzheimer's disease. The study highlights how these compounds may modulate molecular mechanisms involved in disease development, while noting challenges such as limited bioavailability and blood-brain barrier permeability.
Protective Effect of Astragaloside IV against Cadmium-Induced Damage on Mouse Renal Podocytes (MPC5)
This paper is not about microplastics; it investigates how the plant compound Astragaloside IV protects kidney cells from cadmium-induced damage, examining mitochondrial and autophagy pathways.
Gastroprotective Effects of Periplaneta americana L. Extract Against Ethanol-Induced Gastric Ulcer in Mice by Suppressing Apoptosis-Related Pathways
Researchers examined the gastroprotective effects of Periplaneta americana extract against ethanol-induced gastric ulcers in mice, finding that the extract suppressed apoptosis-related pathways and protected gastric tissue from programmed cell death.
Dimethyl Bisphenolate Ameliorates Carbon Tetrachloride-Induced Liver Injury by Regulating Oxidative Stress-Related Genes
Researchers synthesized a novel compound called dimethyl bisphenolate and tested its ability to protect against chemically induced liver injury in rats and cell models. They found that the compound significantly reduced liver damage markers and oxidative stress in a dose-dependent manner, with effects comparable to the established liver protectant silymarin. The study suggests that dimethyl bisphenolate may help protect liver cells by regulating oxidative stress pathways and reducing cell death.
Nanoplastic-Induced Liver Damage Was Alleviated by Maltol via Enhancing Autophagic Flow: An In Vivo and In Vitro Study
Researchers found that nanoplastic exposure caused liver damage in mice through oxidative stress, cell death, and impaired cellular recycling processes. They then tested maltol, a compound derived from red ginseng, and found it significantly reduced the liver damage by restoring healthy autophagy and reducing oxidative stress. The study suggests that natural compounds like maltol could potentially help protect the liver from the harmful effects of nanoplastic accumulation.
Network pharmacology analysis combined with experimental validation to explore the therapeutic mechanism of salidroside on intestine ischemia reperfusion
Researchers investigated the therapeutic mechanism of salidroside for intestinal ischemia-reperfusion injury using network pharmacology and experimental validation, finding that it may target AMPK and TXNIP domains to provide protective effects.
Antioxidant Potential of Mangifera foetida Bark, Mangifera foetida Leaves, and Cinnamomum burmanii Leaves Extract in Mitigating Nanoplastic‐Induced Toxicity and Disruption of Glycolipid Metabolism
Researchers tested whether plant extracts from Mangifera foetida and Cinnamomum burmanii could reduce nanoplastic-induced metabolic disruption in rats, finding that the antioxidant compounds in these extracts partially mitigated nanoplastic-associated disruption of glycolipid metabolism.
Use of untargeted metabolomics to profile the foliar metabolome of Mitragyna speciosa under varying light and water conditions
Researchers used untargeted metabolomics to profile how light intensity and water availability shape the foliar chemistry of kratom seedlings, finding that high light reduced nitrogen-based alkaloids while increasing photoprotective compounds, and that low light combined with low water triggered an antioxidant stress response.
Hydroalcoholic extract of Haematoxylum brasiletto protects Caenorhabditis elegans from cadmium-induced toxicity
Researchers found that a plant extract from Haematoxylum brasiletto, a Mexican tree, protected the tiny roundworm Caenorhabditis elegans from cadmium poisoning, a toxic heavy metal found in industrial pollution. The results suggest the extract contains compounds that may counteract the damaging effects of cadmium exposure.
The Essential Oil from Conyza bonariensis (L.) Cronquist (Asteraceae) Exerts an In Vitro Antimelanoma Effect by Inducing Apoptosis and Modulating the MAPKs, NF-κB, and PKB/AKT Signaling Pathways
Researchers investigated the anticancer potential of an essential oil extracted from Conyza bonariensis against melanoma cells in laboratory experiments. They found that the oil's major compound interacted with key signaling pathways involved in cell survival and induced programmed cell death in melanoma cells. The study suggests this plant-derived compound may warrant further investigation as a potential source of anti-melanoma agents.
Petrosamine isolated from marine sponge Petrosia sp. demonstrates protection against neurotoxicity in vitro and in vivo
Researchers isolated a compound called petrosamine from a Brazilian marine sponge and tested its ability to protect against neurotoxicity in both human neuroblastoma cells and zebrafish embryos, finding it showed promise against hallmarks of Alzheimer's disease. The results suggest that ocean-derived compounds may offer new avenues for developing treatments for neurodegenerative diseases.
Hepatoprotective effects of astragalin against polystyrene microplastics induced hepatic damage in male albino rats by modulating Nrf-2/Keap-1 pathway
Researchers investigated whether astragalin, a natural plant compound, could protect against liver damage caused by polystyrene microplastics in rats. They found that microplastic exposure triggered oxidative stress and inflammation in the liver, but astragalin treatment restored antioxidant enzyme activity and reduced damage. The study suggests that natural compounds may help counteract some of the harmful effects microplastics have on liver health.
The Impact of Microalgae and Their Bioactive Compounds on Liver Well-being in Rats Subjected to Synthetic Phenolic Antioxidants
This review examines how microalgae and their bioactive compounds — including polysaccharides, pigments, and polyphenols — protect liver health in animal models, summarizing evidence for anti-inflammatory and antioxidant mechanisms. The authors note that algal-derived compounds show hepatoprotective effects in rodent studies, though human clinical evidence remains limited.
The potential mechanism of huazhuojiedu decoction in the treatment of ulcerative colitis based on network pharmacology and experimental validation
Researchers used network pharmacology to identify 119 active components and 146 potential targets of the traditional Chinese medicine formula Huazhuojiedu decoction relevant to ulcerative colitis, then validated key predicted mechanisms in dextran sulfate sodium-induced rat colitis models, elucidating multi-target pathways underlying the formula's clinically observed therapeutic effects.
Galangin attenuates oxidative stress-mediated apoptosis in high glucose-induced renal tubular epithelial cells through modulating renin–angiotensin system and PI3K/AKT/mTOR pathway
Researchers found that a plant compound called galangin protected kidney cells from damage caused by high blood sugar by reducing oxidative stress and activating protective signaling pathways. While focused on diabetes treatment, this research is not directly related to microplastic contamination.
Repetitive Transcranial Magnetic Stimulation Improves Neuropathy and Oxidative Stress Levels in Rats with Experimental Cerebral Infarction through the Nrf2 Signaling Pathway
Repetitive transcranial magnetic stimulation treatment of rats with experimentally induced cerebral infarction reduced neurological deficits, lowered oxidative stress markers, and increased expression of the Nrf2 and HO-1 protective pathway proteins, suggesting that rTMS exerts neuroprotective effects after ischemia-reperfusion injury partly through antioxidant signaling.
Polystyrene nanoplastics induce cognitive dysfunction and dendritic spine deterioration via excessive mitochondrial fission
Researchers demonstrated that polystyrene nanoplastics can cross the blood-brain barrier and accumulate in mouse brains, leading to cognitive impairment and loss of connections between brain cells. The damage was driven by excessive splitting of mitochondria, the energy-producing structures within cells, which triggered runaway cellular cleanup processes. Importantly, a drug that blocks this mitochondrial splitting reversed the cognitive damage, suggesting a potential therapeutic approach to nanoplastic-related brain injury.
Alpha‐Mangostin Alleviates Mitochondrial Damage and Autophagy Dysregulation in the MPP + Cellular Model of Parkinson’s Disease
Researchers found that alpha-mangostin pretreatment protected neuronal cells from mitochondrial damage in a cellular model of Parkinson's disease, working through the mTOR autophagy pathway to reduce oxidative stress and improve mitochondrial integrity under conditions mimicking MPP⁺ toxicity.