We can't find the internet
Attempting to reconnect
Something went wrong!
Hang in there while we get back on track
Papers
61,005 resultsShowing papers similar to Silent Invaders: the emerging impact of micro-, nanoplastics and plasticizers on human placental development and pregnancy outcomes
ClearYear 116 of the plastic age: a Pandora’s box as a time bomb for pregnancy? Review of clinical and fundamental data on prenatal exposure to plastics
This review examined evidence for micro- and nanoplastic presence in the human placenta and assessed implications for pregnancy outcomes, synthesizing in vitro, ex vivo, and epidemiological data. Multiple plastic types were detected in placental tissue from the basal plate to fetal membranes, and the authors raised concerns about placental dysfunction and fetal developmental risk.
Microplastics: A threat to Fetoplacental unit and Reproductive systems
This review examines how micro- and nanoplastics may harm the placenta and reproductive system, particularly during pregnancy. The authors highlight that these tiny plastic particles have been found in placental tissue and may interfere with fetal development, though they note that much more research is needed to understand the full risks to mothers and babies.
Micro/Nanoplastic Exposure on Placental Health and Adverse Pregnancy Risks: Novel Assessment System Based upon Targeted Risk Assessment Environmental Chemicals Strategy
Using a new risk assessment framework, researchers evaluated 40 studies on how micro- and nanoplastics affect the placenta during pregnancy. They found a moderate-to-low risk of reproductive harm, with smaller particles posing greater danger by disrupting cell function and triggering cell death in placental tissue. These findings suggest that widespread plastic pollution could have implications for pregnancy health.
Placental Exposure to Nanoplastics Threatening the Maternal and Fetal Health
This review examines how nanoplastics reaching the placenta threaten maternal and fetal health, summarizing evidence from animal and in vitro studies showing that placental nanoplastic accumulation disrupts nutrient transport, immune function, and fetal development.
Placental Micro- and Nanoplastic Contamination: A Systematic Review of Eco-Exposome Pathways to Preterm Birth and Neonatal Outcomes
This systematic review examined evidence that micro- and nanoplastics have been found in human placentas and may be linked to preterm birth. The particles appear to cause inflammation, oxidative stress, and disruption of placental function through multiple molecular pathways, raising concerns about the impact of plastic pollution on pregnancy outcomes and newborn health.
Breach of Security? Placental Uptake of Micro- and Nanoplastic Particles
This review examines emerging evidence for placental uptake of micro- and nanoplastic particles, exploring whether the placenta's barrier function can be breached by these contaminants during pregnancy. The review raises concerns about potential fetal exposure to plastic particles and the implications for developmental health.
"Unseen Dangers: The Effects of Micro- and Nanoplastics on Human Reproductive Health - A Narrative Review"
This review examines the effects of micro- and nanoplastics on human reproductive health, covering evidence from in vitro, animal, and epidemiological studies showing that plastic particles can disrupt hormone signaling, sperm function, ovarian development, and placental integrity.
Microplastics exposure: implications for human fertility, pregnancy and child health
This review examines growing evidence that microplastics accumulate in the human placenta and may affect pregnancy outcomes and child development. Given that exposure during pregnancy can program lifelong health in offspring, the presence of these tiny plastic particles in reproductive tissues raises important concerns about fertility, pregnancy complications, and children's health.
Gestational exposure to micro- and nanoplastics leads to poor pregnancy outcomes by impairing placental trophoblast syncytialization
Researchers found that exposing pregnant mice to micro- and nanoplastics led to increased embryo loss, reduced embryonic weight, and smaller placentas. The plastic particles impaired a critical process called syncytialization, where placental cells fuse together to form a functional barrier, by activating a stress-response signaling pathway. The study suggests that prenatal microplastic exposure could disrupt placental development and contribute to poor pregnancy outcomes.
Understanding the impact of nanoplastics on reproductive health: Exposure pathways, mechanisms, and implications
This review summarizes existing research on how nanoplastics (tiny plastic particles smaller than one micrometer) affect reproductive health in animals and potentially humans. Studies show that nanoplastics can accumulate in reproductive organs including the placenta, and evidence from animal studies links exposure to hormone disruption, reduced fertility, and developmental problems. The authors highlight a significant knowledge gap about nanoplastic effects on human reproduction, despite growing evidence that these particles reach our reproductive systems.
Assessing microplastics as a novel threat to maternal-fetal health: Placental barrier penetration and fetal developmental consequences
This review addressed how microplastics cross the placental barrier and affect fetal development, covering cellular responses in placental tissue, animal model findings, and limited human study data. The authors concluded that transplacental microplastic transfer is a plausible mechanism for intergenerational health effects.
Impact of prenatal micro/nanoplastics exposure on intrauterine development and growth: a systematic review
This systematic review examines how exposure to micro- and nanoplastics during pregnancy may affect fetal development and growth. The research gathered evidence showing that tiny plastic particles can reach the placenta and potentially disrupt normal intrauterine development. While more research is needed, these findings raise important questions about protecting pregnant women from microplastic exposure through food, water, and air.
Editorial: Maternal-fetal interface: new insight in placenta research, volume II
This editorial compiles research showing that microplastics have been detected in human placental tissue and induce cytotoxicity, oxidative stress, and metabolic disturbances in placental explants. The collection of studies underscores that environmental contaminants including microplastics represent a significant and urgent threat to placental function and fetal development.
Maternal-fetal implications of exposure to phthalates and nanoplastics during pregnancy in rats
Researchers studied the maternal-fetal implications of exposure to phthalates and PET nanoplastics during rat pregnancy, examining effects on placental function and fetal development. The study investigates how these endocrine-disrupting compounds accumulate in gestating animals and tests the hypothesis that adverse in utero conditions from plastic chemical exposure affect offspring development.
The Invisible Threat: Microplastics in Human Blood and Placenta
This review summarized current evidence on microplastic detection in human blood and placenta, discussing what is known about how these particles enter the bloodstream and reach fetal tissue. The authors highlight the potential implications for maternal and fetal health.
Nanoplastics at the Placenta–Fetal Interface: Emerging Chemical Toxicology Concerns
Researchers reviewed how nanoplastics interact with trophoblasts at the placenta-fetal interface, identifying plastic additives, surface chemistry, and adsorbed protein coronas as drivers of oxidative stress and disrupted cellular function, and calling for advanced placental models to guide developmental toxicity risk assessment.
Micro- and nanoplastic inhalation during pregnancy: Impacts on uteroplacental function and offspring health
This review examined evidence that inhaled micro- and nanoplastics during pregnancy accumulate in placental and fetal tissues, impair uteroplacental blood flow and immune function, and are associated with adverse developmental outcomes in offspring, identifying inhalation as a critical but understudied exposure route.
Microplastics in the Perinatal Period: Emerging Evidence on Maternal Exposure, Placental Transfer, and Fetal Health Outcomes
This review summarizes emerging evidence that microplastics can cross the placenta and reach developing babies, having been detected in maternal blood, placental tissue, amniotic fluid, cord blood, and breast milk. The tiny plastic particles may damage the placenta, disrupt hormones, alter immune responses, and potentially affect fetal growth and brain development. While more research is needed, the findings raise serious concerns about microplastic exposure during pregnancy and its implications for infant health.
Nano-scale dangers: Unravelling the impact of nanoplastics on human trophoblast invasion
Researchers exposed human trophoblast cells — which form the placenta — to 40 nm and 200 nm polystyrene nanoparticles and found that the smaller particles reduced expression of invasion-related proteins (integrins, N-cadherin, matrix metalloproteinase-2) and impaired cell migration, suggesting nanoplastics may interfere with early placental development.
Maternal exposure to phthalates and nanoplastics, isolated or combined: Impacts on placental structure, development, and antioxidant defense as a trigger for maternal-fetal adversities
Researchers exposed pregnant rats to a mixture of phthalates and nanoplastics, both separately and in combination, to study effects on the placenta and fetal development. They found that combined exposure caused more severe damage to placental structure and antioxidant defenses than either contaminant alone. The study suggests that simultaneous exposure to these common plastic-derived pollutants during pregnancy may compound risks to maternal and fetal health.
A Systematic Review of the Placental Translocation of Micro- and Nanoplastics
Nine out of eleven studies confirmed that micro- and nanoplastics can cross the placental barrier, with translocation depending on particle size, charge, chemical modification, and protein corona formation. Animal and in vitro studies showed emerging evidence of placental and fetal toxicity from plastic particle exposure.
Impact of Microplastics on Pregnancy and Fetal Development: A Systematic Review
A systematic review of 12 studies confirmed the presence of microplastics ranging from 2.1 to 100 micrometers in human placentas and fetal tissue. Microplastic levels correlated with reduced birthweight, affected gestational age, diminished microbiome diversity, and impaired fetal growth and development, with lifestyle choices influencing placental microplastic burden.
Microplastics: A threat for developing and repairing organs?
This review examines how micro- and nanoplastics may affect organ development and repair in humans and animals. Researchers found evidence that these particles and their chemical additives can disrupt critical developmental processes in multiple organs, including during fetal development via placental exposure. The study suggests that micro- and nanoplastics pose particular risks during early developmental windows and when the body is attempting to regenerate damaged tissue.
Exposure of the human placental primary cells to nanoplastics induces cytotoxic effects, an inflammatory response and endocrine disruption
Scientists exposed human placental cells to polystyrene nanoparticles at concentrations found in human blood and observed cell death, inflammation, and disrupted hormone production, with smaller 20-nanometer particles causing more damage than larger ones. This is significant because the placenta is the critical barrier protecting developing babies, and these findings suggest nanoplastics may interfere with pregnancy hormones and placental function at real-world exposure levels.