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Nanoplastics at the Placenta–Fetal Interface: Emerging Chemical Toxicology Concerns
Summary
Researchers reviewed how nanoplastics interact with trophoblasts at the placenta-fetal interface, identifying plastic additives, surface chemistry, and adsorbed protein coronas as drivers of oxidative stress and disrupted cellular function, and calling for advanced placental models to guide developmental toxicity risk assessment.
The interaction of nanoplastics with trophoblasts can potentially disrupt fetal development. The additives associated with nanoplastics, their surface chemistry, and protein corona may lead to oxidative stress and affect the cellular functions. Detailed studies revealing a clear mechanism using an advanced placental model is essential to assess developmental toxicity and guide risk assessment.