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61,005 resultsShowing papers similar to Intergenerational and transgenerational reproductive toxicity of polystyrene microplastics in female mice
ClearMaternal exposure to polystyrene nanoplastics during gestation and lactation caused fertility decline in female mouse offspring
When pregnant mice were exposed to nanoplastics during pregnancy and nursing, their female offspring had significantly reduced fertility as adults. The nanoplastics caused premature activation of egg cells in the ovaries and damaged crucial connections between eggs and their supporting cells. This raises concerns that a mother's exposure to nanoplastics could have lasting effects on her daughters' ability to have children.
Impact of polystyrene microplastics (PS-MPs) on the entire female mouse reproductive cycle: Assessing reproductive toxicity of microplastics through in vitro follicle culture
Female mice exposed to polystyrene microplastics suffered significant damage to their reproductive systems, including ovarian cell death, abnormal egg development, and fewer offspring. The microplastics accumulated in the ovaries and triggered cell death pathways while disrupting survival signaling in the cells that support egg development, suggesting microplastic exposure could contribute to declining fertility.
Transplacental and lactational transfer of polystyrene nanoplastics leads to long-term ovarian impairment in rat offspring
Researchers found that polystyrene nanoplastics crossed the placental barrier in rats and accumulated in fetal and postnatal ovaries, causing dose-dependent damage to follicle development and ovarian structure. Exposed offspring showed reduced primordial follicle numbers, granulosa cell disorganization, and hormonal imbalances that persisted through postnatal day 60. The study suggests that maternal nanoplastic exposure during pregnancy and lactation may have long-lasting effects on female reproductive development.
Effects of polystyrene nanoplastics on the female reproductive system in mice: Implications for ovarian function and follicular development
Researchers exposed female mice to polystyrene nanoplastics orally for 29 days and examined the effects on their reproductive systems. They found that nanoplastic exposure disrupted estrous cycles, impaired follicle development, and altered hormone levels in a dose-dependent manner. The study suggests that nanoplastics, due to their extremely small size, may cross biological barriers and accumulate in reproductive tissues, raising concerns about potential effects on fertility.
Maternal Polystyrene Microplastic Exposure during Gestation and Lactation Altered Metabolic Homeostasis in the Dams and Their F1 and F2 Offspring
Researchers exposed pregnant mice to polystyrene microplastics during pregnancy and nursing and found significant metabolic disruptions in both the mothers and their offspring across two generations. The microplastics altered lipid metabolism, gut microbiota composition, and key metabolic signaling pathways. The study suggests that microplastic exposure during critical developmental windows may have lasting health consequences that pass to future generations.
Polystyrene Microplastics Affect the Reproductive Performance of Male Mice and Lipid Homeostasis in Their Offspring
Researchers found that long-term exposure to environmentally relevant doses of polystyrene microplastics over 21 weeks significantly impaired reproductive function in male mice, including decreased testicle weight and sperm quality. The study also revealed transgenerational effects, with offspring showing disrupted lipid homeostasis.
Lactating exposure to microplastics at the dose of infants ingested during artificial feeding induced reproductive toxicity in female mice and their offspring
When nursing mice were exposed to microplastics at levels matching what infants ingest from plastic baby bottles, the mothers developed reproductive problems including delayed puberty, irregular cycles, and reduced fertility. Strikingly, their male offspring also showed decreased sperm count and quality, even though they were only exposed through breast milk. This suggests microplastics can cause reproductive harm that passes from mother to child, with males being especially vulnerable.
Polystyrene microplastics induced female reproductive toxicity in mice
Researchers exposed female mice to polystyrene microplastics for 35 days and found the particles accumulated in multiple organs including the ovaries, where they caused inflammation and oxidative stress. The microplastics reduced egg quality by lowering protective antioxidants, disrupting mitochondrial function, and altering calcium levels in the cells. This study provides evidence that microplastic exposure could harm female fertility by directly damaging the ovaries and the eggs they produce.
Reproductive toxicity of polystyrene nanoplastics in Drosophila melanogaster under multi-generational exposure
Researchers exposed fruit flies to polystyrene nanoplastics across five consecutive generations and found increasing reproductive harm over time, including reduced egg laying and offspring survival. The damage worsened with each generation even at the same exposure levels, suggesting cumulative effects. The study indicates that nanoplastic exposure may pose growing reproductive risks across generations of organisms.
The reproductive and transgenerational toxicity of microplastics and nanoplastics: A threat to mammalian fertility in both sexes
This review examines how microplastics and nanoplastics can accumulate in reproductive organs and harm fertility in both males and females. In animal studies, exposure led to damaged sperm, disrupted hormones, and abnormal ovary and uterus structure. Offspring of exposed mothers also showed metabolic problems, immune issues, and cognitive disorders, suggesting these particles may affect future generations.
Perinatal exposure to polystyrene microplastics induces multigenerational impairment of male reproduction via disrupted steroidogenesis and proteostasis
Scientists found that when pregnant and nursing rats were exposed to tiny plastic particles (microplastics), their male babies and grandbabies had damaged reproductive systems with lower sperm counts and reduced fertility hormones. While the grandbabies showed some ability to recover from this damage, the study suggests that microplastics in our environment could potentially harm male fertility across multiple generations. This research is concerning because humans are increasingly exposed to microplastics through food, water, and air.
Exposure to Polystyrene Nanoplastics Compromise Ovarian Reserve Function and Endometrial Decidualization in Early Pregnant Mice
Female mice exposed to polystyrene nanoplastics for 90 days before pregnancy had fewer successful pregnancies, smaller pups, and damaged ovaries with reduced egg counts. The nanoplastics disrupted key reproductive hormones and interfered with the uterine process needed for embryo implantation. This study raises concerns that nanoplastic exposure through food and water could harm female fertility and pregnancy outcomes in humans.
Maternal exposure to polystyrene nanoplastics during gestation and lactation induces hepatic and testicular toxicity in male mouse offspring
Researchers exposed pregnant and nursing mice to polystyrene nanoplastics and studied the effects on their male offspring. The offspring showed reduced body weight, liver damage with inflammation and disrupted sugar metabolism, and testicular harm including decreased sperm counts. The findings suggest that nanoplastic exposure during pregnancy and breastfeeding can cause significant organ damage in the next generation.
Maternal exposure to polystyrene nanoplastics leads to ovotoxicity in female mouse offspring
Researchers exposed pregnant mice to polystyrene nanoplastics throughout mating, pregnancy, and nursing, then examined the ovaries of their female offspring. They found that maternal nanoplastic exposure significantly reduced ovarian weight and follicle numbers in the offspring and lowered the expression of key antioxidant genes. The study suggests that nanoplastic exposure during pregnancy may pose risks to the reproductive development of female offspring.
Polystyrene microplastics impaired decidualization in mice via oxidative stress and inflammation and disrupted the reproductive function of their female offspring
Mouse experiments found that polystyrene microplastics impaired uterine decidualization and embryo implantation via oxidative stress and inflammation, and that maternal PS-MP exposure also disrupted the reproductive function of female offspring.
Reproductive toxicity of microplastics in female mice and their offspring from induction of oxidative stress
When female mice were fed microplastics for 30 days, their egg quality, fertilization rates, and fertility dropped significantly due to oxidative stress and DNA damage. Even more concerning, the reproductive harm carried over to the next generation, with the daughters of exposed mice also showing reduced fertility. This study suggests that microplastic exposure could affect not just a person's own reproductive health but also that of their children.
Dual impact of microplastic exposure in a mouse model: Impaired uterine receptivity and altered maternal-offspring metabolism
Researchers exposed female mice to polystyrene microplastics and found that the particles impaired uterine receptivity, which is critical for embryo implantation, and altered metabolic profiles in both the mothers and their offspring. The microplastics disrupted gene expression related to uterine function and caused metabolic changes across multiple organs. The findings suggest that microplastic exposure could have reproductive and metabolic consequences that extend to the next generation.
Comparing the effects of polystyrene microplastics exposure on reproduction and fertility in male and female mice
Researchers exposed both male and female mice to polystyrene microplastics for 30 to 44 days and found that the particles accumulated more in ovaries than testes, causing oxidative stress and reproductive damage in both sexes. Male mice had fewer viable sperm and more deformed sperm, while female mice had smaller ovaries with fewer eggs, and both sexes showed altered hormone levels and reduced fertility. This study suggests that microplastic exposure could contribute to declining fertility in both men and women.
Reproductive toxicity and related mechanisms of micro(nano)plastics in terrestrial mammals: Review of current evidence.
This review of terrestrial mammal studies found that micro- and nanoplastics induce reproductive toxicity through oxidative stress, inflammation, endocrine disruption, and DNA damage, affecting both male and female fertility. In males, effects include blood-testis barrier disruption and impaired spermatogenesis, while females show compromised oocyte maturation, ovarian fibrosis, and diminished ovarian reserve, with particles also capable of crossing the maternal-fetal interface.
Teratological, neurochemical and histomorphic changes in the limbic areas of F1 mice progeny due to co-parental polystyrene nanoplastic exposure
Researchers exposed parent mice to polystyrene nanoplastics before and during pregnancy and found that offspring exhibited skeletal and visceral malformations, impaired neonatal reflexes, learning deficits, and structural brain changes — including reduced hippocampal neurons — demonstrating transgenerational neurodevelopmental harm from nanoplastic exposure.
Can Mammalian Reproductive Health Withstand Massive Exposure to Polystyrene Micro- and Nanoplastic Derivatives? A Systematic Review
This systematic review examined how polystyrene micro- and nanoplastics affect reproductive health in mammals. The evidence from animal studies shows these particles can cause oxidative stress, inflammation, and hormonal imbalances in reproductive organs, raising concerns about potential effects on human fertility.
Micro-nanoplastics pollution and mammalian fertility: A systematic review and meta-analysis
This meta-analysis of 79 studies across five mammalian species found that micro- and nanoplastics cause reproductive toxicity in a concentration-dependent manner, particularly at high doses. Polystyrene was the most studied polymer, and most research focused on male fertility in mice, leaving a significant gap in knowledge about effects on food-producing animals that could serve as vectors for human exposure.
Polystyrene nanoplastics induced transgenerational reproductive toxicity in Caenorhabditis elegans through enhanced DNA damage accompanied by DNA repair inhibition
Researchers exposed roundworms (C. elegans) to polystyrene nanoplastics at environmentally relevant concentrations and found that reproductive harm persisted across multiple generations, even after exposure stopped. The nanoplastics caused DNA damage while simultaneously suppressing the organisms' DNA repair mechanisms, creating a compounding effect. The study suggests that nanoplastic exposure may have lasting consequences that are passed down through generations, amplifying harm beyond the originally exposed organisms.
The ovarian-related effects of polystyrene nanoplastics on human ovarian granulosa cells and female mice
This study tested the effects of polystyrene nanoplastics on both human ovarian cells in the lab and on female mice. The nanoplastics accumulated in ovarian tissue, caused cell death, disrupted hormone levels, and reduced egg quality and fertility in mice. These findings suggest that nanoplastic exposure could threaten female reproductive health by damaging the ovaries.