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Perinatal exposure to polystyrene microplastics induces multigenerational impairment of male reproduction via disrupted steroidogenesis and proteostasis
Summary
Scientists found that when pregnant and nursing rats were exposed to tiny plastic particles (microplastics), their male babies and grandbabies had damaged reproductive systems with lower sperm counts and reduced fertility hormones. While the grandbabies showed some ability to recover from this damage, the study suggests that microplastics in our environment could potentially harm male fertility across multiple generations. This research is concerning because humans are increasingly exposed to microplastics through food, water, and air.
Microplastics (MPs) are pervasive environmental contaminants that pose potential health risks through multiple exposure routes. Although their toxic effects have attracted increasing concern, their multigenerational impacts remain poorly understood. This study investigated the reproductive effects of maternal exposure to polystyrene microplastics (PS-MPs) during gestation and lactation, on male offspring across two generations (F1 and F2) of Sprague-Dawley rats. Results demonstrated that maternal PS-MPs exposure induced significant reproductive toxicity in both F1 and F2 male offspring, manifesting as impaired testicular development with reduced sperm count, and accompanied by increased oxidative stress and DNA damage, as indicated by elevated levels of ROS, 8-OHdG, and γ-H2AX. In the F1 generation, we observed suppressed testosterone synthesis and endoplasmic reticulum (ER) stress, characterized by decreased levels of testosterone and steroidogenic acute regulatory protein (StAR), along with increased GRP78. Interestingly, the F2 generation exhibited a distinct adaptive response, characterized by the upregulation of StAR and Serine arginine-rich splicing factor 1 (SRSF1), suggesting that modulation of steroidogenesis and RNA splicing may partially counteract the reproductive impairment induced by ancestral exposure. In conclusion, gestational and lactational exposure to PS-MPs induces multigenerational reproductive toxicity in male offspring. However, compensatory mechanisms appear to attenuate these effects in the F2 generation. These findings provide crucial experimental evidence for the comprehensive assessment of multigenerational reproductive risks from microplastic exposure.