We can't find the internet
Attempting to reconnect
Something went wrong!
Hang in there while we get back on track
Papers
61,005 resultsShowing papers similar to The Role of Thrombin Time as an Independent Variable in Predicting In-Stent Stenosis Risk After Flow Diverter Treatment for Intracranial Aneurysms: A Retrospective Cohort Study
ClearMicrofluidic-based in vitro thrombosis model for studying microplastics toxicity
Researchers developed a microfluidic-based thrombosis model to study how microplastics interact with the vascular system. Using both a mouse model and an on-chip system, the study found that microplastic exposure led to accumulation in the blood and decreased binding of fibrin to platelets, suggesting a potential risk of thrombus instability in blood flow.
Microplastic Effects on Thrombin–Fibrinogen Clotting Dynamics Measured via Turbidity and Thromboelastography
Researchers found that microplastics directly altered fibrin clot formation dynamics in a human thrombin-fibrinogen model, with effects varying by plastic type, size, and concentration, suggesting potential impacts on blood clotting and cardiovascular health.
Microplastic Effects on Thrombin-Fibrinogen Clotting Dynamics Measured via Turbidity
Researchers found that non-modified polystyrene microplastics significantly slowed fibrin clot formation in a laboratory model — reducing clotting rate up to 27-fold — while aminated polystyrene had minimal effect, suggesting microplastic surface chemistry may influence blood coagulation dynamics.
Multimodal detection and analysis of microplastics in human thrombi from multiple anatomically distinct sites
This study used multiple detection methods to find and analyze microplastics in blood clots (thrombi) collected from different locations in the human body. The detection of microplastics within blood clots from various anatomical sites suggests that plastic particles may play a role in clot formation. This research adds to mounting evidence linking microplastic presence in the cardiovascular system to potential heart and stroke risks.
Microplastics and Nanoplastics in Atheromas and Cardiovascular Events
This landmark clinical study found that patients with micro- and nanoplastics detected in their carotid artery plaque had a significantly higher risk of heart attack, stroke, or death over a 34-month follow-up period compared to those without detectable plastics. This is one of the first studies to directly link microplastic presence in human blood vessels to worse cardiovascular outcomes. The findings suggest that plastic accumulation in arteries may be an important and previously unrecognized risk factor for heart disease.
PB1065 Microvesicles Display Opposite Coagulolytic Balances According to Their Cellular Origin and Activation Status
Polystyrene microplastics activated human vascular endothelial cells, upregulating inflammation markers ICAM-1 and VCAM-1, and promoted larger and denser blood clot formation when added to whole blood perfused over collagen at concentrations found in human plasma. These results raise concern that microplastics circulating in human blood could increase the risk of thrombosis and cardiovascular events.
The Effect of Peroral Polyvinyl Chloride Microplastic on the Value of Prothrombin Time and Activated Partial Thromboplastin Time in Rattus Norvegicus Wistar Strain
Researchers found that Wistar rats given 0.5 mg/day of PVC microplastics orally exhibited altered prothrombin time and activated partial thromboplastin time values compared to controls, suggesting that microplastic accumulation in the liver impairs hepatocyte synthesis of blood clotting factors.
Abstract TP089: Micro and Nano plastics in Cerebrovascular Health: A systematic Review of Current Evidence and Research Directions
This systematic review examines emerging evidence linking micro- and nanoplastics to cerebrovascular health problems. Studies found plastic particles in human brain blood vessels and arterial plaques, with evidence suggesting they may promote inflammation and oxidative stress that could contribute to stroke risk.
Microplastics are associated with elevated atherosclerotic risk and increased vascular complexity in acute coronary syndrome patients
Researchers found that blood microplastic levels were highest in heart attack patients, followed by patients with chest pain, and lowest in those with clear arteries, with polyethylene being the most common type detected. The findings suggest that microplastic accumulation in the bloodstream may be associated with increased risk of atherosclerosis and coronary artery disease.
Microplastics and Cardiovascular Disease: Should Clinicians Be Paying Attention?
This clinical review summarizes evidence for microplastics as a cardiovascular risk factor, noting that they have been detected in human cardiovascular tissues and that in vitro and animal studies link them to oxidative stress, endothelial dysfunction, and platelet disruption, while cautioning that human evidence remains associative.
Abstract TMP110: Impact of Microplastics and Nanoplastics on Ischemic Stroke in Mice
Researchers investigated the effect of polyethylene and polystyrene micro/nanoplastics on ischemic stroke outcomes in mice using a transient middle cerebral artery occlusion model. Daily MNP pretreatment before stroke induction was assessed for effects on infarct volume and neurological outcomes, exploring the emerging hypothesis that MNPs may be a cerebrovascular risk factor.
A case-control study linking concentrations of microplastics in human cerebrospinal fluid to intracranial aneurysm risk
In a case-control study, researchers detected seven types of microplastics in the cerebrospinal fluid of both intracranial aneurysm patients and controls, with polyethylene and polypropylene being the most abundant. The study found that higher levels of polypropylene and PVC in cerebrospinal fluid were associated with a significantly elevated risk of intracranial aneurysm, suggesting a potential link between microplastic exposure and cerebrovascular health.
Microplastic particles in human blood and their association with coagulation markers
In a study of 36 healthy adults, microplastics were detected in the blood of 89% of participants, with polypropylene and polyethylene being the most common types found. Higher microplastic levels were associated with changes in blood clotting markers, suggesting that plastic particles in our bloodstream may affect how our blood coagulates, though larger studies are needed to confirm this link.
Abstract Tu0030: Carotid Plaque Microplastics are Associated with Clinical Symptoms and Mesenchymal Stem Cell-Macrophage Immunomodulatory Effects
This conference abstract reports findings from a study linking micronanoplastic content in carotid artery plaques with clinical symptoms and with altered immune signaling mediated by mesenchymal stem cells. Patients with symptomatic carotid stenosis had higher plaque microplastic loads, and stem cells modulated the inflammatory response in ways that differed based on microplastic presence.
Micro- and nanoplastics are elevated in femoral atherosclerotic plaques compared with undiseased arteries
Researchers found significantly higher concentrations of microplastics and nanoplastics in diseased arterial plaques from human patients with limb-threatening vascular disease compared to healthy arteries, adding to growing evidence that these particles accumulate in cardiovascular tissue and may play a role in artery disease.
Microplastics. a New Risk Factor for Atherosclerotic Cardiovascular Disease
This paper reviews emerging evidence linking microplastic exposure to atherosclerotic cardiovascular disease, noting that MPs have been detected in arterial plaques and human tissues and may contribute to cardiovascular risk through inflammation, oxidative stress, and endothelial disruption.
Percutaneous coronary intervention leads to microplastics entering the blood: Interventional devices are a major source
Researchers measured microplastic levels in the blood of 23 patients before and after heart stent procedures (percutaneous coronary intervention) and found that microplastic concentrations jumped nearly 19-fold after the procedure. The types of plastics found in the blood matched those detected on the medical devices used during the procedure, confirming that the devices themselves were the source. This study reveals that common medical procedures using plastic equipment may be an overlooked route for microplastics to enter the human bloodstream.
Microplastics and Nanoplastics in Atheromas
Researchers raise methodological concerns about a widely cited study that found microplastics and nanoplastics in arterial plaque, noting that the lack of contamination controls, the unusually small particle sizes detected, and the limited verification methods make it difficult to confirm whether the particles came from inside the body or were introduced during surgery.
Tissue-specific distribution of microplastics in human blood and carotid plaques: A paired sample analysis
In a study of 20 patients undergoing surgery for clogged neck arteries, researchers found microplastics in both blood and artery plaque samples from every patient. The plaques contained nearly six times more microplastics than blood, suggesting that plastics accumulate in damaged blood vessels. Some types of microplastics were linked to changes in cholesterol levels, raising questions about whether plastic particles could worsen heart disease.
Micro- and Nanoplastics as a Potential Risk Factor for Stroke: A Systematic Review
This systematic review assessed the potential link between micro- and nanoplastics and stroke risk. It found that plastic particles have been detected in human blood vessels and arterial plaques, and may contribute to inflammation and blood vessel damage — factors that could increase the risk of stroke.
P69 | Microplastics and Atherosclerosis: Evidence of Microplastics in Carotid Atherosclerotic Plaques
This conference abstract reports the detection of multiple types of microplastics in human coronary, carotid, and aortic arteries, finding higher MP concentrations in arteries with atherosclerotic plaques than in plaque-free aortic tissue, suggesting a link between microplastic accumulation and arterial disease.
Exploring microplastic impact on whole blood clotting dynamics utilizing thromboelastography
Researchers used a blood clotting analysis technique to study how polystyrene microplastics of different sizes and surface types affect human blood clotting. They found that negatively charged particles consistently activated the clotting process, increasing both the speed and strength of clot formation in a size-dependent manner. The findings highlight that microplastic surface chemistry and particle size play important roles in how these particles might interact with blood.
Microfluidic thrombosis analysis system: possibilities and limitations
This paper reviewed microfluidic thrombosis analysis systems, discussing their possibilities and limitations for studying clot formation dynamics under controlled flow conditions relevant to cardiovascular disease research.
Weekly Journal Scan: Plastic particles in carotid plaques—inactive debris or predictors of cardiovascular events?
This journal scan summarizes a prospective multicenter study that detected microplastics and nanoplastics in excised carotid artery plaques and found that higher plaque burden of plastic particles was associated with increased risk of cardiovascular events. The findings raise the possibility that microplastics in arterial tissue are not inert but biologically active.