Papers

A meta-analysis-based adverse outcome pathway for the male reproductive toxicity induced by microplastics and nanoplastics in mammals

This meta-analysis of 39 studies mapped the adverse outcome pathway for microplastic and nanoplastic-induced male reproductive toxicity in mammals. Increased reactive oxygen species triggers a cascade of cellular damage including mitochondrial dysfunction, sperm DNA damage, and disrupted hormone signaling, ultimately leading to reduced sperm quality, impaired spermatogenesis, and decreased testosterone levels.

Epithelial Barrier Theory: The Role of Exposome, Microbiome, and Barrier Function in Allergic Diseases

This review presents the epithelial barrier theory, which proposes that damage to the body's protective barriers is a key driver of allergic diseases. Researchers identified numerous environmental factors including microplastics, nanoparticles, detergents, and processed food additives that can weaken epithelial barriers in the skin, lungs, and gut. The study suggests that the rising prevalence of allergies may be linked to increasing exposure to barrier-disrupting substances in our modern environment.

P10-03 Polystyrene nanoplastics exposure during early life induces testis development disorder in male offspring through m6A methylation

P10-04 Polystyrene nanoplastics exposure during pregnancy and lactation induces testis development disorder in male offspring in mice