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Author response for "Nanoplastics from Single-Use Polyethylene Terephthalate Bottles Impair the Functionality of Human Gut-Dwelling Lactobacillus rhamnosus and Induce Toxicity in Human Cells"
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Nanoplastics from single-use polyethylene terephthalate bottles impair the functionality of human gut-dwelling Lactobacillus rhamnosus and induce toxicity in human cells
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Researchers synthesized nanoplastics from single-use PET water bottles and tested their effects on the gut probiotic Lactobacillus rhamnosus, red blood cells, and human lung cells. They found that the nanoplastics reduced probiotic survival in a dose-dependent manner, damaged cell membranes, and impaired the bacteria's beneficial functions including antioxidant activity. The study provides evidence that nanoplastics released from everyday plastic bottles could disrupt important gut bacteria and harm human cells.
Impact of Micro-nanoplastics on Gut and Immune Function
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This review examined how micro- and nanoplastics disrupt gut microbiota and immune function across aquatic and terrestrial vertebrates, with implications for human health. Because the gut microbiome governs immune regulation and metabolic health, microplastic-induced dysbiosis represents a plausible mechanism by which plastic ingestion could drive systemic inflammation and disease beyond the GI tract.
Microplastics and nanoplastics in the human gut: from signals to standards
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Researchers outlined major methodological gaps in current studies on microplastic and nanoplastic exposure through the human gastrointestinal tract, proposing minimum standards for study design and reporting to move the field from preliminary signals toward causal evidence linking gut plastic exposure to specific health outcomes.
Gut microbiome alterations associated with microplastics: Underestimated risk from tiny particle
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This review pulls together existing research showing that tiny plastic particles, found in our food, water, and even air, can disrupt the balance of bacteria living in our gut, and this disruption has been linked to problems ranging from digestive diseases to effects on the brain, liver, and reproductive system in animal studies. The catch: scientists still struggle to accurately detect and measure these particles in the body, meaning our real-world exposure and its health effects are likely underestimated. Bottom line, microplastics may be quietly messing with your gut health in ways we're only beginning to understand and measure.
Micro-nanoplastics induce the physiological toxicity and metabolic disorder of Bacillus cereus DFH-1
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Researchers exposed the bacterium Bacillus cereus to micro- and nanoplastics of varying polymer types and sizes, finding that 150 nm PET nanoparticles caused the greatest harm—inhibiting early growth, deforming cell morphology, reducing antioxidant enzyme activity, and broadly disrupting metabolic pathways including the tricarboxylic acid cycle.
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