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Process insights for harnessing biotechnology for plastic depolymerization
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Researchers reviewed biotechnological advances in plastic depolymerization, highlighting how engineered ester hydrolases now enable industrial-scale PET recycling, while plastics with carbon-only backbones such as polyolefins likely require hybrid chemo-biotechnological approaches that combine thermal deconstruction with microbial metabolism of the resulting small molecules.
Plastics (synthetic polymers) play an essential role in modern living, but their uncontrolled disposal has led to severe environmental impacts. The production of plastics is based on fossil feedstocks, which are associated with detrimental climate effects. Thus, sustainable concepts for the re- and upcycling of plastic waste are urgently required. Biotechnological approaches have recently emerged as innovative alternatives to conventional methods. Engineered ester hydrolases have enabled large-scale industrial recycling of the abundant polyester polyethylene terephthalate through monomer recovery, and recently discovered novel enzymes can depolymerize other plastics with hydrolyzable backbones. For plastics with only saturated carbon–carbon bonds in their backbones, such as polyolefins and polystyrene, a chemo-biotechnological process appears to be a viable option, where engineered microorganisms can metabolize small-molecule products from a (thermo)chemical polymer deconstruction to produce value-added products. Here recent achievements using biocatalytic and biotechnological methods are discussed. Plastics play an essential role in modern life, but their uncontrolled disposal has led to severe environmental impacts. Sustainable strategies for reusing plastics waste are urgently needed. This Perspective examines biotechnological solutions for plastics recycling and upcycling, with an emphasis on the process-oriented challenges involved in achieving a circular plastics economy.
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