We can't find the internet
Attempting to reconnect
Something went wrong!
Hang in there while we get back on track
The ameliorative effects of grape seed extract on bisphenol-A-induced reproductive toxicity and upregulated vitellogenin mRNA levels in Nile tilapia
AI summary Read the abstract
This study found that bisphenol A (BPA) exposure in Nile tilapia disrupted reproductive hormones, reduced sperm and egg quality, and elevated oxidative stress markers, while dietary supplementation with grape seed extract significantly reversed these effects by boosting antioxidant defenses and restoring gonadal health.
Abstract Aquatic pollution has increased significantly in recent decades due to increased waste from various sources. Pollutants like bisphenol A (BPA) are endocrine disruptors that interfere with natural hormones, impacting development, fertility, and homeostasis. This study assessed the impact of BPA on the freshwater fish Oreochromis niloticus , focusing on genotoxicity, reproductive toxicity, and endocrine disruption. It also explored the protective effects of dietary grape seed extract (GREX ® ) against BPA toxicity. One hundred eighty mixed-sex fish, averaging 15.04 ± 0.13 g, were randomly divided into four groups (three replicates each). The first group served as the control (0 mg GREX ® /kg), the second group received 200 mg GREX ® /kg, the third group was exposed to 3 mg BPA/L in water, and the fourth group received 3 mg BPA/L and 200 mg GREX ® /kg. Treatments lasted for 60 days. Body weight, gonadosomatic index (GSI), hepatosomatic index (HSI), cholesterol, triglycerides (TG), estradiol (E2), testosterone (T), cortisol, gonadal malondialdehyde (MDA), and superoxide dismutase (SOD) were measured. A histopathological examination of the liver, testes, and ovaries was conducted. BPA exposure induced significant pathophysiological alterations, including a significant decrease in GSI, HSI, E2, T, and gonadal antioxidant enzymes, while increasing cortisol, cholesterol, triglycerides (TG), and gonadal MDA. It also resulted in detrimental gonadal histology and downregulation of vitellogenin (VTG) mRNA levels. However, GREX ® significantly improved these BPA-induced effects and restored the VTG mRNA levels. GREX ® likely ameliorates BPA reproductive toxicity via antioxidant and stress-relieving mechanisms that improve gonadal sex hormones and pathology.
More Papers Like This
Dietary Protective Influence of Petroselinum crispum Nanoparticles on Some Biochemical, Reproductive Hormones, and Physiological Biomarkers of Female Clarias gariepinus (Burchell, 1822) Exposed to Bisphenol A Toxicity
AI summary Read the abstract
Researchers found that parsley nanoparticles (PNPs) significantly mitigated the toxic effects of bisphenol A (BPA) in female African catfish, restoring disrupted blood profiles, liver and kidney markers, antioxidant enzyme activity, and reproductive hormones including estradiol, FSH, and LH.
Multi-mechanistic effects of bisphenol A on testicular dysfunction and endocrine disruption in adult male Labeo bata: oxidative stress, inflammation, and dysregulated energy sensors
AI summary Read the abstract
Researchers studied how bisphenol A (BPA), a chemical that leaches from microplastics in water, affects reproductive function in male fish. They found that chronic BPA exposure at environmentally relevant concentrations caused significant testicular damage, including reduced sperm production, increased inflammation, and disrupted hormone signaling. The study reveals multiple mechanisms by which this common microplastic-associated chemical can impair male reproductive health in aquatic species.
Microplastics induced endocrine disruption, alteration in testicular tissue in tilapia (Oreochromis niloticus) pre-fed on Amphora coffeaeformis
AI summary Read the abstract
Researchers found that microplastic exposure caused hormonal disruption, reduced sperm quality, and damaged testicular tissue in male tilapia fish, but pre-feeding the fish with a microalgae feed supplement partially protected against these reproductive harms. The study suggests that dietary interventions may help mitigate microplastic toxicity in fish farmed for human consumption.
Bisphenol A Induces Histopathological, Hematobiochemical Alterations, Oxidative Stress, and Genotoxicity in Common Carp (Cyprinus carpio L.)
AI summary Read the abstract
Researchers investigated the toxic effects of bisphenol A, a plastics-related endocrine disruptor, on common carp at different dose levels over 30 days. The study found dose-dependent reductions in blood cell counts, increased oxidative stress in the brain, liver, gills, and kidneys, and significant tissue damage, indicating that BPA exposure poses risks to aquatic organisms.
Assessing the recovery of steroid levels and gonadal histopathology of tilapia exposed to polystyrene particle pollution by supplementary feed
AI summary Read the abstract
Researchers investigated whether supplementary feed containing probiotics and vitamin C could mitigate the reproductive harm caused by polystyrene particle exposure in tilapia, assessing steroid levels and gonadal histopathology after exposure. Results indicated that plastic particle pollution negatively affected tilapia reproduction and that probiotic and vitamin C supplementation offers a potential dietary strategy to counter these effects.
Research digests by email
When a large batch of papers lands in the Atlas, we read through it and send a short write-up of what stood out.