We can't find the internet
Attempting to reconnect
Something went wrong!
Hang in there while we get back on track
Bisphenol A Induces Histopathological, Hematobiochemical Alterations, Oxidative Stress, and Genotoxicity in Common Carp (Cyprinus carpio L.)
AI summary Read the abstract
Researchers investigated the toxic effects of bisphenol A, a plastics-related endocrine disruptor, on common carp at different dose levels over 30 days. The study found dose-dependent reductions in blood cell counts, increased oxidative stress in the brain, liver, gills, and kidneys, and significant tissue damage, indicating that BPA exposure poses risks to aquatic organisms.
Bisphenol A (BPA) is one of the environmental endocrine disrupting toxicants and is widely used in the industry involving plastics, polycarbonate, and epoxy resins. This study was designed to investigate the toxicological effects of BPA on hematology, serum biochemistry, and histopathology of different organs of common carp (Cyprinus carpio). A total of 60 fish were procured and haphazardly divided into four groups. Each experimental group contained 15 fish. The fish retained in group A was kept as the untreated control group. Three levels of BPA 3.0, 4.5, and 6 mg/L were given to groups B, C, and D for 30 days. Result indicated significant reduction in hemoglobin (Hb), lymphocytes, packed cell volume (PCV), red blood cells (RBC), and monocytes in a dose-dependent manner as compared to the control group. However, significantly higher values of leucocytes and neutrophils were observed in the treated groups (P < 0.05). Results on serum biochemistry revealed that the quantity of glucose, cholesterol, triglycerides, urea, and creatinine levels was significantly high (P < 0.05). Our study results showed significantly (P < 0.05) increase level of oxidative stress parameters like reactive oxygen species (ROS) and thiobarbituric acid reactive substances (TBARS) and lower values of antioxidant enzymes (superoxide dismutase (SOD), catalase (CAT), peroxidase (POD) in treated groups (4.5 mg/L and 6 mg/L)) in the brain, liver, gills, and kidneys. Our study depicted significant changes in erythrocytes (pear shaped erythrocytes, leptocytes, microcytes, spherocytes, erythrocytes with broken, lobed, micronucleus, blabbed, vacuolated nucleus, and nuclear remnants) among treated groups (4.5 mg/L and 6 mg/L). Comet assay showed increased genotoxicity in different tissues including the brain, liver, gills, and kidneys in the treated fish group. Based on the results of our experiment, it can be concluded that the BPA exposure to aquatic environment is responsible for deterioration of fish health, performance leading to dysfunction of multiple vital organs.
More Papers Like This
New Insights Into Hematological, Serum Biochemical and Histopathological Toxicity of Bisphenol a on Bighead Carp (Aristichthys Nobils) Under Long-Term Exposure
AI summary Read the abstract
Bighead carp exposed to bisphenol A (BPA) — a chemical used in plastic manufacturing — for 60 days showed organ damage, blood abnormalities, and hormonal disruption at higher doses. BPA leaches from plastics and represents a key chemical exposure pathway alongside microplastic ingestion.
Long-term exposure of endangered Danube sturgeon (Acipenser gueldenstaedtii) to bisphenol A (BPA): growth, behavioral, histological, genotoxic, and hematological evaluation
AI summary Read the abstract
Researchers exposed endangered Danube sturgeon to bisphenol A (BPA), a chemical used in plastics, finding that even low concentrations reduced growth, damaged liver tissue, caused DNA strand breaks, and disrupted blood cell counts — raising concern for wild fish populations living in BPA-contaminated waterways.
Bisphenol A Used in Plastic Industry Negatively Affects Wild Vimba Bream (Vimba vimba)
AI summary Read the abstract
Researchers found that long-term exposure of wild vimba bream to bisphenol A caused significant histopathological damage in liver and gill tissues and altered antioxidant enzyme activity, demonstrating the endocrine-disrupting chemical's harmful effects on freshwater fish.
Toxic effects of microplastic (polyethylene) exposure: Bioaccumulation, hematological parameters and antioxidant responses in crucian carp, Carassius carassius
AI summary Read the abstract
Researchers exposed crucian carp to polyethylene microplastics at various concentrations and found that the particles accumulated in tissues including gills, gut, and liver. The microplastics altered blood cell counts and disrupted the fish's antioxidant defense system in a dose-dependent manner. The study suggests that even common polyethylene microplastics can cause measurable biological harm in freshwater fish.
Ecotoxicological effects of polystyrene nanoplastics on common carp: Insights into blood parameters, DNA damage, and gene expression
AI summary Read the abstract
Exposing common carp to polystyrene nanoplastics caused significant DNA damage in blood and brain cells, along with changes in genes related to immune function and stress response. Higher concentrations led to more severe effects, and the nanoplastics also disrupted liver antioxidant defenses. Since carp are widely consumed fish, these findings raise questions about the safety of fish from nanoplastic-contaminated waters for human consumption.
Research digests by email
When a large batch of papers lands in the Atlas, we read through it and send a short write-up of what stood out.