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Quercetin protects chicken mesenchymal stem cells from DEHP- induced toxicity by modulating the ROS/Wnt/β-catenin pathway
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Researchers found that quercetin, a plant-derived flavonoid, protects chicken mesenchymal stem cells from the plasticizer DEHP by modulating the ROS/Wnt/β-catenin signaling pathway, suggesting a dietary antioxidant mechanism that could counteract phthalate-induced tissue damage.
Di-2-ethylhexyl phthalate (DEHP), a ubiquitous plasticizer, induces systemic organ damage primarily via oxidative stress. Quercetin (Que), a flavonoid abundant in vegetables, possesses anti-inflammatory, anti-allergic, and antioxidant properties. Whether Que protects avian gizzard tissue again...
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Correction by "Quertin" of the oxidative-antioxidant system of rats at xenobiotics exposure
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This study tested whether the antioxidant flavonoid quercetin could protect rats from oxidative damage caused by xenobiotic (foreign chemical) exposure, finding that quercetin administration reduced biomarkers of oxidative stress and liver damage. The results suggest that natural antioxidants may help counteract some biochemical effects of environmental chemical exposures.
Quercetin attenuates polystyrene nanoplastic-induced intestinal barrier injury through modulation of macrophage inflammatory responses
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In mice and lab-grown cells, nanoscale polystyrene plastic particles damaged the gut lining and triggered inflammatory immune cell activity. Quercetin, a plant compound, reduced this inflammation and partially restored proteins that help keep the intestinal barrier intact.
Exploration of potential targets and toxicological mechanisms of microplastic exposure-induced osteoarthritis based on network toxicology, molecular docking and experimental validation
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Scientists found that tiny plastic particles (microplastics), which we regularly ingest through food and air, may damage joint cartilage and contribute to osteoarthritis by disrupting specific genes involved in inflammation and cell damage. Using computer modeling and lab experiments on cartilage cells, researchers also found that quercetin—a natural compound found in fruits and vegetables—may help protect against this damage, though more research is needed before it could be recommended as a treatment. This study adds to growing concerns about how everyday plastic exposure might affect joint health, while pointing toward a possible natural way to help defend against it.
Quercetin intervention mitigates small intestinal damage and immunologic derangement induced by polystyrene nanoplastics: Insights from multi-omics analysis in mice
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Researchers found that quercetin, a natural compound found in fruits and vegetables, protected mice from gut damage and immune system disruption caused by polystyrene nanoplastics. The nanoplastics damaged the small intestine and disrupted immune balance, but quercetin reversed much of this harm by restoring healthy gut bacteria and gene activity. This suggests that dietary compounds like quercetin might help counteract some negative health effects of nanoplastic exposure.
Attenuative effects of tamarixetin against polystyrene microplastics‐induced hepatotoxicity in rats by regulation of Nrf‐2/Keap‐1 pathway
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Researchers investigated whether tamarixetin, a naturally occurring flavonoid, could reduce liver damage caused by polystyrene microplastic exposure in rats. The study found that tamarixetin helped protect against microplastic-induced liver toxicity by activating antioxidant defense pathways, suggesting potential protective effects of certain plant-derived compounds against microplastic-related oxidative stress.
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When a large batch of papers lands in the Atlas, we read through it and send a short write-up of what stood out.