Quercetin protects chicken mesenchymal stem cells from DEHP- induced toxicity by modulating the ROS/Wnt/β-catenin pathway

Huiling Zheng; Xinyu Huo; Chenxi Huang; Wenwen Zhang; Kang Yang; Tong Xu; Hongjin Lin

doi:10.21203/rs.3.rs-7530959/v1

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Quercetin protects chicken mesenchymal stem cells from DEHP- induced toxicity by modulating the ROS/Wnt/β-catenin pathway

The Journal of Physical Chemistry B 2025

Huiling Zheng, Xinyu Huo, Chenxi Huang, Wenwen Zhang, Kang Yang, Tong Xu, Hongjin Lin

Summary

Researchers found that quercetin, a plant-derived flavonoid, protects chicken mesenchymal stem cells from the plasticizer DEHP by modulating the ROS/Wnt/β-catenin signaling pathway, suggesting a dietary antioxidant mechanism that could counteract phthalate-induced tissue damage.

Body Systems

Immune

Di-2-ethylhexyl phthalate (DEHP), a ubiquitous plasticizer, induces systemic organ damage primarily via oxidative stress. Quercetin (Que), a flavonoid abundant in vegetables, possesses anti-inflammatory, anti-allergic, and antioxidant properties. Whether Que protects avian gizzard tissue again...

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