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Total absence of colony-stimulating factor 1 in the macrophage-deficient osteopetrotic ( op/op ) mouse
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This research highlights the rising concern over micro- and nanoplastic pollution, with nanoplastics viewed as particularly worrying because their small size enables them to cross protective biological barriers. A significant knowledge gap persists due to limited tools for detecting particles below 1 micrometer.
Micro-nano plastics originating from the prevalent usage of plastics have raised increasingly alarming concerns worldwide. However, there remains a fundamental knowledge gap in nanoplastics because of the lack of effective analytical ...Plastics are now omnipresent in our daily lives. The existence of microplastics (1 µm to 5 mm in length) and possibly even nanoplastics (<1 μm) has recently raised health concerns. In particular, nanoplastics are believed to be more toxic since their ...
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Ingestion of micro- and nanoplastic perturbs tissue homeostasis and macrophage core functions
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Researchers fed mice polystyrene particles chronically and found that micro- and nanoplastics breached intestinal barriers and accumulated in multiple organs, disrupting tissue homeostasis and impairing core macrophage functions including phagocytosis and inflammatory regulation.
Nanoplastic impact on bone microenvironment: A snapshot from murine bone cells.
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This study examined how nanoplastics affect bone cell function in a murine model, investigating effects on osteoblasts and osteoclasts that govern bone formation and resorption in the bone microenvironment. Nanoplastic exposure altered bone cell activity, suggesting that daily plastic particle exposure could have long-term implications for bone health.
Nanoplastic impact on bone microenvironment: A snapshot from murine bone cells
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This study found that nanoplastics are toxic to bone cells in mice, causing cell death, increased production of damaging reactive oxygen species, and disruption of the bone remodeling process. The nanoplastics impaired the ability of bone-building cells to migrate and promoted the formation of bone-destroying cells. These findings suggest that nanoplastic exposure could potentially contribute to bone diseases like osteoporosis, though more research in living animals and humans is needed.
Human osteoblast-like cells exhibit anabolic attenuation and catabolic phenotypic signals after exposure to polystyrene microplastics
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Researchers exposed human bone-building cells (osteoblast-like cells) to polystyrene microplastics in a lab setting. The cells showed reduced signals linked to building new bone and increased signals linked to bone breakdown, suggesting microplastics may affect cell activity related to bone health.
Nanoplastic impact on bone microenvironment: A snapshot from murine bone cells.
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Researchers investigated how nanoplastics affect the bone microenvironment using murine bone cell models, examining effects on osteoblast and osteoclast activity that regulate bone formation and resorption. Nanoplastic exposure disrupted bone cell function, raising concerns about skeletal health impacts from daily plastic particle exposure.
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When a large batch of papers lands in the Atlas, we read through it and send a short write-up of what stood out.