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Article ? AI-assigned paper type based on the abstract. Classification may not be perfect — flag errors using the feedback button. Tier 2 ? Original research — experimental, observational, or case-control study. Direct primary evidence. Gut & Microbiome Human Health Effects Sign in to save

Hepatotoxicity induced by polylactic acid microplastics: The mediating role of gut microbiota and uric acid metabolism

Journal of Advanced Research 2025 8 citations ? Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count.
Yanhong Deng, Yanhong Deng, Zhiming Li, Yuji Huang, Yuji Huang, Yizhou Zhong, Alex Qiu, Xiaohong Chen, Xiyun Huang, Xiaohong Yang, Xiaohong Yang, Yujie Feng, Ruobing Bai, Bingchi Fan, Hongyi Xian, Hongyi Xian, Hao Li, Da Chen, Boxuan Liang, Zhenlie Huang

Summary

Researchers found that polylactic acid (PLA) microplastics, often marketed as biodegradable and eco-friendly, caused liver damage in a study by disrupting gut bacteria and raising uric acid levels. The gut microbiome changes triggered by PLA microplastics were the key driver of the liver injury, not direct contact with the liver. This challenges the assumption that biodegradable plastics are safe and highlights the gut-liver connection in microplastic toxicity.

Polymers
PLA
Body Systems
Hepatic

Our findings demonstrate that PLA MP-induced liver damage is mediated by gut microbiota-driven elevation of uric acid. This highlights the critical role of systemic factors, particularly gut microbiota, in assessing the hepatotoxicity of PLA MPs.

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