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RETRACTED: Toxicity of polystyrene nanoplastics in Ctenopharyngodon idella juveniles: A genotoxic, mutagenic and cytotoxic perspective
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Researchers exposed juvenile grass carp (Ctenopharyngodon idella) to polystyrene nanoplastics and assessed genotoxic, mutagenic, and cytotoxic endpoints, finding DNA damage and cellular abnormalities at tested concentrations (note: this paper was subsequently retracted).
The increased contamination of surface water with plastic waste is proportional to the increased consumption of products that use them as raw material. However, the impact of these residues on aquatic biota remains limited, mainly when it comes to nanoplastics (NPs). Thus, the aim of the current study is to test the hypothesis that the exposure of Ctenopharyngodon idella juveniles to polystyrene nanoplastics (PS NPs) at low concentrations (0.04 ng/L, 34 ng/L and 34 μg/L), for 20 days, leads to DNA damage and has mutagenic and cytotoxic effects on their erythrocytes. Comet assay enabled observing that DNA damage (inferred from the greater tail length, DNA percentage in the tail and Olive tail moment) induced by PS NPs has increased as the pollutant concentrations have increased, as well as that the formation of micronuclei and other nuclear abnormalities was equitable in animals exposed to this pollutant. On the other hand, there were significant changes in erythrocyte shape and size, oxidative stress generation (NO levels, lipid peroxidation, hydrogen peroxide), antioxidant system inhibition (mediated by total hepatic glutathione) and PS NPs accumulation in the liver and brain of animals exposed to higher concentrations of it. Therefore, the current study has confirmed the initial hypothesis and enhanced the knowledge about the genotoxic, mutagenic and cytotoxic potential of PS NPs in freshwater fish at early developmental stage, relating these effects to biochemical changes and significant accumulation of these nanomaterials. Besides, it is a warning about the (eco) toxicological risk represented by these nanopollutants in aquatic environments. CAPSULE: Polystyrene nanoplastics are capable of inducing DNA damage, mutagenic and cytotoxicity changes in fish.
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Exposing common carp to polystyrene nanoplastics caused significant DNA damage in blood and brain cells, along with changes in genes related to immune function and stress response. Higher concentrations led to more severe effects, and the nanoplastics also disrupted liver antioxidant defenses. Since carp are widely consumed fish, these findings raise questions about the safety of fish from nanoplastic-contaminated waters for human consumption.
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Researchers exposed grass carp to different sizes and concentrations of polystyrene microplastics for up to 14 days, followed by a depuration period, and assessed physiological and intestinal microbiome effects. The study found that microplastics caused histological damage, oxidative stress, and shifts in gut microbial communities, with smaller particles and higher concentrations producing more severe effects.
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Researchers exposed common carp (Cyprinus carpio) to polystyrene particles in a controlled laboratory setting, measuring survival, growth, histological damage, and oxidative stress markers over a 30-day period. Exposed fish showed liver and gill tissue damage alongside elevated oxidative stress enzymes, demonstrating that polystyrene microplastics are harmful to freshwater fish at tested concentrations.
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