We can't find the internet
Attempting to reconnect
Something went wrong!
Hang in there while we get back on track
Precision Nutrition Redefined: Integrative Molecular Frameworks for Personalized Dietary Interventions
AI summary Read the abstract
This review explored the biochemical and molecular foundations of personalized nutrition, integrating nutrigenetics, epigenomics, microbiomics, and metabolomics to tailor dietary strategies to individual biology. The authors identified environmental contaminants, including microplastics, as factors that may interact with genetic and metabolic profiles to influence nutritional outcomes.
Personalized nutrition represents a transformative paradigm in dietary science, aligning nutritional strategies with individual biological variability to optimize health outcomes and reduce chronic disease risk.This review explores the biochemical, molecular, and technological foundations of personalized nutrition, emphasizing its basis in nutrigenetics, epigenetics, microbiomics, and metabolomics.It examines how genetic polymorphisms, such as SNPs in genes like MTHFR, FTO, and APOE, influence nutrient metabolism and disease susceptibility, necessitating genotype-informed dietary interventions.Epigenetic mechanisms, including DNA methylation and histone modifications, dynamically regulate gene expression in response to dietary inputs and can be targeted through nutrient-specific interventions, especially during critical developmental windows.The gut microbiome is highlighted as a key determinant of individual dietary responses, with personalized modulation through prebiotics and probiotics showing benefits in nutrient absorption, metabolic regulation, and immune function.Metabolomic profiling offers real-time insights into nutrient utilization, enabling the development of biomarker-based dietary plans tailored to individual metabolic phenotypes.Integrating these omics technologies with digital health tools and artificial intelligence has allowed for more accurate and scalable nutrition strategies, paving the way for truly individualized interventions.Despite rapid advancements, the review also addresses major ethical, regulatory, and equity challenges, including concerns about data privacy, accessibility, and the standardization of nutrigenomic practices.It calls for robust multidisciplinary frameworks to ensure responsible implementation and equitable access.Furthermore, emerging areas such as microbiotaderived metabolites, bioactive herbal compounds, circadian-linked nutrient metabolism, and environmental exposures (e.g., microplastics) are discussed as novel biochemical considerations in personalized nutrition.In conclusion, personalized nutrition holds immense potential to revolutionize healthcare by translating molecular insights into actionable, precise, and preventive dietary recommendations.Its successful implementation requires continued innovation, ethical oversight, and a commitment to inclusivity across clinical and public health domains.
More Papers Like This
Multi-Omics Approach on the Ecotoxicological Assessment of Microplastics
AI summary Read the abstract
This review examines the application of multi-omics approaches — including genomics, transcriptomics, proteomics, and metabolomics — to the ecotoxicological assessment of microplastics in living organisms. The authors synthesize how these integrated molecular tools are advancing understanding of the mechanistic pathways by which microplastics disrupt biological systems, offering a more comprehensive picture than single-endpoint toxicity studies.
Microplastics to Metabolomics: Understanding the environmental and health implications of plastic pollution
AI summary Read the abstract
This review explores how metabolomics, a technique for analyzing small molecules in biological systems, is being used to understand how microplastic exposure affects living organisms at the biochemical level. The authors examine both targeted and untargeted metabolomics approaches that can reveal changes in metabolic pathways caused by microplastic pollution. The study suggests that metabolomics could become a powerful tool for identifying early biomarkers of microplastic-related health effects.
Molecular Mechanisms of Environmental Pollutants in Human Health for Unravelling the Pathophysiology of Chronic Diseases
AI summary Read the abstract
This review examined the integrated molecular mechanisms by which environmental pollutants—including heavy metals, persistent organic pollutants, endocrine disruptors, and microplastics—contribute to chronic diseases such as cancer, cardiovascular disease, and neurodegenerative conditions. The authors found that multiple pollutant classes converge on oxidative stress, epigenetic modification, and inflammatory signaling as shared pathogenic pathways.
Healthful Diet and Nutritional Food as a Preventive and Interventional Paradigm in the Face of Microplastic and Nanoplastic Crisis
AI summary Read the abstract
This review examines dietary patterns and nutritional interventions as potential strategies to reduce health risks from microplastic and nanoplastic exposure, discussing how antioxidant-rich foods and specific nutrients may mitigate inflammation and oxidative stress triggered by MNP ingestion.
Untoward Effects of Micro- and Nanoplastics: An Expert Review of Their Biological Impact and Epigenetic Effects
AI summary Read the abstract
This expert review examined the biological and epigenetic effects of micro- and nanoplastics on living organisms. The study suggests that while intestinal uptake of plastic particles appears relatively low and size-dependent, nanoplastics may dysregulate molecular signaling pathways, alter gut microbiota composition, and induce transgenerational epigenetic changes potentially linked to metabolic disorders.
Research digests by email
When a large batch of papers lands in the Atlas, we read through it and send a short write-up of what stood out.