Polystyrene microplastics induce metabolic disturbances in marine medaka (Oryzias melastigmas) liver

Gauging the effects of a chronic exposure to polystyrene nanoplastics in the liver and intestine of Carassius auratus

Aging enhances the ecological toxicity of polyethylene microplastics to marine medaka larvae (Oryzias melastigma)

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Researchers found that UV- and Fenton-aged polyethylene microplastics caused greater harm to marine medaka larvae than virgin plastic, disrupting gut microbiota composition and altering microbial metabolic functions in ways that impaired growth and development, underscoring the need to assess weathered microplastics in ecological risk evaluations.

Polystyrene microplastics: a threat to renal energy metabolism and tissue morphology in Wistar rats

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Researchers orally exposed male Wistar rats to polystyrene microplastics at three doses over four weeks and found dose-dependent disruption of renal energy metabolism, including impaired glycolysis, suppressed gluconeogenesis, and a metabolic shift toward anaerobic pathways, accompanied by progressive histopathological damage including tubular inflammation and loss of Bowman's capsular space.

Polystyrene microplastics induce gut microbiome and metabolome changes in Javanese medaka fish (Oryzias javanicus Bleeker, 1854)

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Researchers found that polystyrene microplastic exposure altered gut microbiome composition and metabolic profiles in Javanese medaka fish, with effects on amino acid and lipid metabolism pathways suggesting microplastics can disrupt gut health in aquatic organisms.

Dietary chitosan reversed the toxic effects of polystyrene microplastics on Nile tilapia (Oreochromis niloticus) liver by inhibiting mitochondrial damage

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Dietary chitosan supplementation reversed polystyrene microplastic-induced liver damage in Nile tilapia by inhibiting mitochondrial damage, oxidative stress, inflammation, and cell death pathways after two weeks of exposure. This demonstrates a potential dietary intervention for mitigating microplastic toxicity in aquatic organisms, with implications for understanding protective strategies against plastic-related biological harm.