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Dietary chitosan reversed the toxic effects of polystyrene microplastics on Nile tilapia (Oreochromis niloticus) liver by inhibiting mitochondrial damage
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Dietary chitosan supplementation reversed polystyrene microplastic-induced liver damage in Nile tilapia by inhibiting mitochondrial damage, oxidative stress, inflammation, and cell death pathways after two weeks of exposure. This demonstrates a potential dietary intervention for mitigating microplastic toxicity in aquatic organisms, with implications for understanding protective strategies against plastic-related biological harm.
In recent years, the environmental pollution caused by microplastics (MPs) has attracted extensive attention. Numerous studies have shown that MPs could cause liver damage in aquatic animals. However, there is a limited range of technical approaches available to mitigate and minimize the detrimental impact of MPs on both wild fish populations and aquaculture operations. Thus, this study aimed to investigate the impact of dietary chitosan supplementation on the prevention and treatment of liver damage induced by exposure to polystyrene microplastics (PS-MPs) in Nile tilapia (Oreochromis niloticus). The results indicated that after two weeks of exposure, the liver of tilapia showed oxidative stress, inflammatory response and fibrosis. Meanwhile, after the chitosan addition, the oxidative stress, inflammatory response and fibrosis of tilapia liver were reversed, the pyroptosis and ferroptosis in tilapia liver were inhibited, the combination of mitochondria with PS-MPs in tilapia liver cells was inhibited, and the mitochondrial damage was reversed. In summary, the study confirmed the potential prophylaxis and treatment effect of dietary chitosan supplementation on PS-MPs exposure-induced liver damage in tilapia, and provided basic data for further studies on prophylaxis and treatment of the toxic effects of MPs. This study also presented efficacious strategies for alleviating the deleterious impacts of MPs on fish farming, thereby fostering sustainable and eco-friendly approaches in aquaculture.
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