We can't find the internet
Attempting to reconnect
Something went wrong!
Hang in there while we get back on track
Metagenomic analysis explores the interaction of aged microplastics and roxithromycin on gut microbiota and antibiotic resistance genes of Carassius auratus
AI summary Read the abstract
Researchers examined how aged polystyrene microplastics interact with the antibiotic roxithromycin in the gut of goldfish using metagenomic analysis. They found that aging enhanced the microplastics' ability to carry and release the antibiotic, leading to greater intestinal inflammation and disruption of gut microbial communities. The combined exposure also selectively enriched antibiotic resistance genes, suggesting that aged microplastics may amplify the ecological risks of antibiotic pollution.
The aging process changes the physicochemical structure of microplastics and affects environmental behaviors and toxicological effects of coexisting pollutants, thereby posing ecological risks. In this study, the effects of aged polystyrene microplastics alone or in combination with the 100 μg/L roxithromycin (ROX) on intestines of Carassius auratus were investigated. The carrier effect of microplastics was enhanced by aging due to changes in functional groups and surface area, which led to an increase in the bioaccumulation of ROX. The combined exposure of aged microplastics (APS) and ROX caused more inflammatory cell infiltration and cilia defects, and significantly inhibited the activity of amylase and lipase. Metagenomic sequencing revealed that the combined exposure of microplastics and ROX increased the abundance of Gemmobacter, Bosea, Rhizobium, and Shinella and decreased the abundance of Cetobacterium and Akkermansia (p < 0.05). The presence of APS enhanced the selective enrichment of antibiotic resistance genes. What's more, the influence of microplastics and antibiotics on gut microbiota was closely related to carbohydrate metabolism and amino acid metabolism activities, as well as the abundance of baca and sul1 resistance genes. These results expand our understanding of the interaction mechanism between APS and antibiotics in real aquatic environment.
More Papers Like This
Aged microplastics change the toxicological mechanism of roxithromycin on Carassius auratus: Size-dependent interaction and potential long-term effects
AI summary Read the abstract
Researchers studied how different sizes of aged microplastics (0.5, 5, and 50 micrometers) affect the toxicity of the antibiotic roxithromycin in goldfish. The study found that microplastics promoted antibiotic accumulation in tissues in a size-dependent manner, with smaller particles worsening liver and brain damage while larger particles caused more intestinal damage, and also altered gut microbiota composition.
Nanoplastics enhance the intestinal damage and genotoxicity of sulfamethoxazole to medaka juveniles (Oryzias melastigma) in coastal environment
AI summary Read the abstract
Scientists exposed young medaka fish to the antibiotic sulfamethoxazole and polystyrene nanoplastics, both individually and together, to study their combined effects on intestinal health. They found that co-exposure caused more severe gut damage than either pollutant alone, disrupting the gut microbiome and triggering changes in gene expression related to immune defense and DNA repair. The study suggests that nanoplastics may amplify the harmful effects of antibiotics on fish in coastal environments.
Unraveling the mechanism of brain damage in Carassius auratus by polypropylene microplastics and oxytetracycline via the brain-gut-microbiota axis
AI summary Read the abstract
Researchers investigated how polypropylene microplastics and the antibiotic oxytetracycline together affect the brain-gut-microbiota axis of goldfish at environmentally realistic levels. They found that microplastics acted as carriers for the antibiotic, leading to significantly higher accumulation in the brain and intestine, worsening inflammation and suppressing key neurotransmitter enzymes. The study suggests that co-exposure to microplastics and antibiotics can trigger nervous system disruption through the gut-brain connection.
Gut microbiota related response of Oryzias melastigma to combined exposure of polystyrene microplastics and tetracycline
AI summary Read the abstract
Researchers exposed estuarine fish to polystyrene microplastics and the antibiotic tetracycline, both alone and in combination, for four weeks. The combined exposure caused more severe disruption to gut bacteria and liver tissue than either pollutant alone, with microplastics appearing to worsen the effects of tetracycline. The study suggests that the co-occurrence of microplastics and antibiotics in coastal waters may pose greater ecological risks than either contaminant by itself.
Subchronic toxicity of dietary sulfamethazine and nanoplastics in marine medaka (Oryzias melastigma): Insights from the gut microbiota and intestinal oxidative status
AI summary Read the abstract
Researchers found that dietary co-exposure to the antibiotic sulfamethazine and polystyrene nanoplastics in marine medaka caused significant disruption of gut microbiota composition and increased intestinal oxidative stress, with combined effects exceeding individual exposures.
Research digests by email
When a large batch of papers lands in the Atlas, we read through it and send a short write-up of what stood out.