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The distinct toxicity effects between commercial and realistic polystyrene microplastics on microbiome and histopathology of gut in zebrafish

Journal of Hazardous Materials 2022 67 citations ? Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count. Score: 55 ? 0–100 AI score estimating relevance to the microplastics field. Papers below 30 are filtered from public browse.

Jing Ding, Min Lv, Jing Ding, Xiaotong Guo, Jing Ding, Jing Ding, Xiaotong Guo, Jing Ding, Jing Ding, Yunqing Wang, Yunqing Wang, Yunqing Wang, Yunqing Wang, Yunqing Wang, Yunqing Wang, Jing Ding, Min Lv, Min Lv, Min Lv, Min Lv, Min Lv, Yunqing Wang, Yunqing Wang, Yunqing Wang, Jing Ding, Jinhua Li, Yunqing Wang, Min Lv, Xiaotong Guo, Jing Ding, Lingxin Chen Yunqing Wang, Jing Ding, Jing Ding, Longwen Fu, Longwen Fu, Lingxin Chen Yunqing Wang, Yunqing Wang, Lingxin Chen Lingxin Chen Lingxin Chen Yunqing Wang, Lingxin Chen Yunqing Wang, Yunqing Wang, Lingxin Chen Longwen Fu, Longwen Fu, Longwen Fu, Lingxin Chen Longwen Fu, Lingxin Chen Lingxin Chen Lingxin Chen Lingxin Chen Lingxin Chen Lingxin Chen Lingxin Chen Min Lv, Xiyan Sun, Xiaoyue Han, Xiyan Sun, Lingxin Chen Lingxin Chen Lingxin Chen Lingxin Chen Lingxin Chen Lingxin Chen Lingxin Chen Min Lv, Jing Ding, Xiyan Sun, Xiyan Sun, Xiaoyue Han, Xiyan Sun, Xiyan Sun, Lingxin Chen Xiyan Sun, Xiyan Sun, Min Lv, Xiyan Sun, Xiyan Sun, Lingxin Chen Lingxin Chen Lingxin Chen Lingxin Chen Lingxin Chen Xiyan Sun, Xiyan Sun, Lingxin Chen Xiyan Sun, Xiyan Sun, Min Lv, Min Lv, Lingxin Chen Lingxin Chen Lingxin Chen Lingxin Chen Lingxin Chen Lingxin Chen Lingxin Chen Lingxin Chen Lingxin Chen

Summary

Researchers compared the toxic effects of commercially manufactured polystyrene microplastics with environmentally weathered ones on the gut microbiome and intestinal tissue of zebrafish. The study found that the two types of microplastics produced distinct effects, suggesting that commonly used commercial microplastics in laboratory studies may not accurately represent the impacts of real-world microplastic pollution.

Polymers

Models

Zebrafish

As a ubiquitous emerging pollutant, microplastics (MPs) have attracted widespread attention. At this stage, researchers mainly employed commercial MPs (CMPs) as the model particles to explore the toxic effects of MPs. But whether CMPs can reflect the effects of realistic MPs (RMPs) still remains unknown. Herein, the effects of commercial and realistic polystyrene MPs on gut microbiota of zebrafish were compared. Considering MPs co-exist with antibiotics in real environment, we further distinguished the effects of CMPs and RMPs when they co-existed with enrofloxacin (ENR). The results revealed that while both CMPs and RMPs significantly shifted the gut microbiota, CMPs exhibited stronger toxic effects and more severe damage to gut. Furthermore, ENR exhibited a distinct effect with both CMPs and RMPs on gut microbiota, while the addition of CMPs and RMPs significantly alleviated the toxicity of ENR. In addition, analysis via Kyoto Encyclopedia of Genes and Genomes pathway database revealed that seven major level 1 pathways associated with metabolism, information processing and diseases in the microbial community were affected. Taken together, this work is the first to report that CMPs could not represent RMPs in terms of toxicity and other behaviors, reminding people the limits of using CMPs in ecotoxicology studies.

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