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Cyanidin-3-O-glucoside impacts fecal discharge of polystyrene microplastics in mice: Potential role of microbiota-derived metabolites
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Researchers found that the dietary compound cyanidin-3-O-glucoside accelerated the fecal discharge of polystyrene microplastics in mice by remodeling gut microbiota composition and altering microbiota-derived metabolites, suggesting a potential dietary strategy for reducing microplastic accumulation.
Microplastic particles degraded from plastic litters are recognized as a global environmental pollutant, which can be transferred and enriched via the food chain to impact ecosystems and human health. A balanced gut microbiota contributes to human health through host-gut interactions, environmentally-driven factors such as microplastic exposure would disturb the gut bacteria and affect its functionality. Dietary compounds can remodel the compositions of gut microbes, and interact with bacteria exerting profound effects on host physiology. This study explored the effects of bayberry-derived anthocyanin cyanidin-3-O-glucoside (C3G) and microplastic polystyrene (PS) on the gut microbiome in C57BL/6 mice, especially the alterations in gut bacteria and its metabolites. Using 16S rRNA high-throughput sequencing, variations in gut bacterial composition and enrichment of functional pathways were found upon PS and C3G administration. Meanwhile, the differential metabolites and metabolic pathways were identified by metabolomic analysis. Importantly, colonic and fecal PS levels were found to be strongly correlated with key microbiota-derived metabolites, which are associated with xenobiotic metabolism via regulation of xenobiotics-metabolizing enzymes and transporters. These results may offer new insights regarding the protective effects of C3G against xenobiotic PS exposure and the roles of gut bacterial metabolites.
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Food-derived cyanidin-3-O-glucoside reverses microplastic toxicity via promoting discharge and modulating the gut microbiota in mice
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In mice exposed to polystyrene microplastics, cyanidin-3-O-glucoside (C3G), an anthocyanin found in many fruits, was given as a supplement. Mice that received C3G had less polystyrene in tissue, more in feces, and lower oxidative stress and inflammation. C3G also shifted gut bacteria linked to inflammation.
Modulation of Gut Microbial Metabolism by Cyanidin-3-O-Glucoside in Mitigating Polystyrene-Induced Colonic Inflammation: Insights from 16S rRNA Sequencing and Metabolomics
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In mice exposed to polystyrene microplastics, cyanidin-3-O-glucoside (C3G), an anthocyanin from red bayberry, reversed the rise in inflammatory signaling molecules in the colon. C3G also reshaped the gut bacterial community and its metabolites. The study used a C57BL/6 mouse model.
Long-term exposure to polystyrene microplastics promotes HFD-induced obesity in mice through exacerbating microbiota dysbiosis
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Researchers found that long-term polystyrene microplastic exposure worsened high-fat-diet-induced obesity in mice by exacerbating gut microbiota dysbiosis, suggesting microplastic ingestion may amplify metabolic disease risk through disruption of the gut microbiome.
Association between microplastics exposure and gut microbiota and metabolites in older adults: A cross-sectional study
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Researchers analyzed fecal samples from 45 older adults to assess the relationship between microplastic exposure and gut microbiota. They found an average of 70 microplastic particles per gram of feces, primarily PVC, butadiene rubber, and polyethylene, and observed that microplastic exposure was associated with changes in gut microbial diversity and metabolite levels. The study suggests that microplastics may influence gut health in older adults by altering bacterial community composition and metabolic pathways.
Deciphering Gut Microbiome Responses upon Microplastic Exposure via Integrating Metagenomics and Activity-Based Metabolomics
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Using advanced metagenomics and metabolomics techniques, researchers studied how polystyrene microplastic exposure affects the gut microbiome in mice. The study found that microplastics disrupted the balance of gut bacteria and altered metabolic pathways related to amino acids and lipids. These findings suggest that microplastic exposure could influence gut health and metabolism, though more research is needed to understand the implications for human health.
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