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LP-68 Subtoxic doses of polystyrene nanoplastics and microcystin-LR affect the bioenergetic status of Caco-2 and HepG2 cells
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Cellular Uptake and Nuclear Accumulation of Polystyrene Nanoplastics in 3T3 Fibroblasts and Hepatocytes of Rattus norvegicus
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Scientists found that tiny plastic particles called nanoplastics can get inside liver and connective tissue cells from rats, and even sneak into the cell's nucleus, where DNA is stored. Cells exposed to these plastics showed signs of stress and damage, including swelling and higher rates of cell death, suggesting these ultra-small plastic particles may be more harmful than previously thought. While this study used animal cells rather than human cells, it raises important questions about what everyday exposure to nanoplastics (found in food packaging, water, and other sources) might mean for our own cellular health.
The presence of polystyrene nanoplastics enhances the MCLR uptake in zebrafish leading to the exacerbation of oxidative liver damage
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Researchers found that polystyrene nanoplastics enhanced the uptake of the toxin microcystin-LR in zebrafish liver over three months of co-exposure, exacerbating oxidative damage and cellular swelling compared to microcystin exposure alone.
Stress (Cortisol) and Hepatotoxic Effects of Polystyrene Micro- and Nanoplastics in Swiss Albino Mice: A Comparative Study
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Researchers exposed Swiss albino mice to polystyrene micro- and nanoplastics and compared the stress and liver toxicity responses, finding that both sizes elevated cortisol levels and caused hepatotoxic damage, with nanoplastics generally producing more pronounced physiological disruption than microplastics.
Exposure of microplastic at levels relevant for human health : cytotoxicity and cellular localization of polystyrene microparticles in four human cell lines
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Researchers tested the cytotoxicity of polystyrene microplastics on four human cell lines at concentrations relevant to real-world human exposure from food, water, and packaging. At environmentally realistic doses, microplastics were taken up by cells but did not cause significant toxicity, though higher concentrations did produce cell damage, suggesting that current exposure levels may be near a threshold of concern.
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