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Stress (Cortisol) and Hepatotoxic Effects of Polystyrene Micro- and Nanoplastics in Swiss Albino Mice: A Comparative Study

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Researchers exposed Swiss albino mice to polystyrene micro- and nanoplastics and compared the stress and liver toxicity responses, finding that both sizes elevated cortisol levels and caused hepatotoxic damage, with nanoplastics generally producing more pronounced physiological disruption than microplastics.

Polymers
Body Systems
Models

Plastic pollution is a global challenge and has emerged as a concerning environmental and public health issue. While the harmful effects of macro plastics are well-known, recent attention has shifted towards smaller microplastics (MPs) and nanoplastic (NPs), which...

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Article Tier 2

Cellular Uptake and Nuclear Accumulation of Polystyrene Nanoplastics in 3T3 Fibroblasts and Hepatocytes of Rattus norvegicus

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Scientists found that tiny plastic particles called nanoplastics can get inside liver and connective tissue cells from rats, and even sneak into the cell's nucleus, where DNA is stored. Cells exposed to these plastics showed signs of stress and damage, including swelling and higher rates of cell death, suggesting these ultra-small plastic particles may be more harmful than previously thought. While this study used animal cells rather than human cells, it raises important questions about what everyday exposure to nanoplastics (found in food packaging, water, and other sources) might mean for our own cellular health.

Article Tier 2

Chronic Toxicity of Polystyrene Microplastics in Blood and Organs of Albino Mice: a Histopathological and Biochemical Assessment

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Researchers assessed chronic toxicity of polystyrene microplastics in albino mice through histopathological and biochemical analysis of blood and organs, examining how repeated exposure alters tissue integrity and physiological markers over time.

Article Tier 2

The toxicity of polyethylene microplastics on molecular and biochemical parameters in albino mice

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Researchers assessed the molecular and biochemical effects of polyethylene microplastic exposure in albino mice, finding dose-dependent toxicity across multiple organ systems, with measurable alterations in liver enzymes, oxidative stress markers, and blood cell parameters consistent with systemic health impacts.

Article Tier 2

Biochemical, Histological and Molecular Docking into the Impact of Polystyrene Nanoplastics on Antioxidant Enzymes and Testicular Health in Rats

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Tiny plastic particles called nanoplastics, found widely in our environment, may harm male fertility, according to a new rat study. Rats exposed to higher doses of these plastics showed weakened antioxidant defenses and physical damage to testicular tissue, including fewer developing sperm cells. While this research was done in rats, not humans, it adds to growing concerns that the microplastics and nanoplastics we're routinely exposed to through food, water, and air could pose risks to reproductive health.

Article Tier 2

Prenatal exposure to polystyrene nanoplastics caused testicular development toxicities and relative mechanisms in male offspring mice from embryo to adulthood

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Scientists exposed pregnant mice to nanoplastics (tiny plastic particles found in our environment, blood, and even placentas) and found their male offspring had slowed growth before birth, hit puberty earlier, and had reduced fertility as adults. The nanoplastics appeared to disrupt key genes and cells needed for normal testicle development and hormone production. While this is animal research, it adds to growing evidence that plastic exposure during pregnancy could affect a baby's reproductive development later in life.

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