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Composition of the gut microbiota at the genus level following the administration of MP.
Summary
Researchers characterized gut microbiota at the genus level in wild-type and leptin-knockout obese mice following microplastic administration, identifying genus-level shifts with significant differences between obese and normal-weight animals that suggest obesity modifies the gut microbiome response to microplastic exposure.
(a) Fecal microbiota distribution at the genus level in WT and Lep KO mice. (b) Relative level of fecal microbiota distribution at the genus level in WT and Lep KO mice. Each color represents one bacterial genus. (c) Heat map showing a significant difference. Different colors indicate the relative abundance of each genus. The data are reported as mean ± SD values. *, p < 0.05 compared to the Vehicle-treated group. #, p < 0.05 compared to the WT mice. Abbreviation: WT; wild type, Lep KO; leptin knockout, MP; microplastics.
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