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Article ? AI-assigned paper type based on the abstract. Classification may not be perfect — flag errors using the feedback button. Tier 2 ? Original research — experimental, observational, or case-control study. Direct primary evidence. Environmental Sources Gut & Microbiome Sign in to save

Composition of the gut microbiota at the genus level following the administration of MP.

Figshare 2025
Yu Sang Choi (22656230), Yu Jeong Roh (14295511), Ji Eun Kim (403026), Hee Jin Song (14295514), Ayun Seol (14295505), Su Jeong Lim (22656233), Su Ha Wang (22656236), Ji Eun Sung (8040404), Ye Eun Ryu (22656239), Ye Ryeong Kim (22656242), Hyun Su Park (6163211), Hong Joo Son (6585203), Yu Jin Kim (804271), Eun Sang Jung (22656245), Sunho Park (2275411), Dae Youn Hwang (766634)

Summary

Researchers characterized gut microbiota at the genus level in wild-type and leptin-knockout obese mice following microplastic administration, identifying genus-level shifts with significant differences between obese and normal-weight animals that suggest obesity modifies the gut microbiome response to microplastic exposure.

Models
Mouse

(a) Fecal microbiota distribution at the genus level in WT and Lep KO mice. (b) Relative level of fecal microbiota distribution at the genus level in WT and Lep KO mice. Each color represents one bacterial genus. (c) Heat map showing a significant difference. Different colors indicate the relative abundance of each genus. The data are reported as mean ± SD values. *, p < 0.05 compared to the Vehicle-treated group. #, p < 0.05 compared to the WT mice. Abbreviation: WT; wild type, Lep KO; leptin knockout, MP; microplastics.

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