Vitamin D Modulates Lipid Metabolism Disorder in Zebrafish (Danio Rerio) Liver Caused by Polystyrene Nanoplastic Exposure

Vitamin D modulates disordered lipid metabolism in zebrafish (Danio rerio) liver caused by exposure to polystyrene nanoplastics

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Researchers found that supplementing zebrafish with vitamin D helped counteract the lipid metabolism disruption caused by nanoplastic exposure. Nanoplastics accumulated in the liver and triggered fat buildup, but a high-vitamin-D diet significantly reduced the number of lipid droplets and restored metabolic balance. The study suggests that adequate vitamin D intake may offer some protective effect against the metabolic harm caused by nanoplastic pollution.

Vitamin D modulation of brain-gut-virome disorder caused by polystyrene nanoplastics exposure in zebrafish (Danio rerio)

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Zebrafish exposed to polystyrene nanoplastics were fed diets low or high in vitamin D. Fish on the high vitamin D diet had 20% less nanoplastic in brain tissue and more than 50% less in the intestine, with less tissue damage, more serotonin and less anxiety-like behavior.

Simulated Environmental Nanoplastics Induce Zebrafish Developmental Toxicity and Stress Response

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Scientists exposed zebrafish embryos to nanoplastics that were specially broken down to mimic how plastic actually degrades in oceans and rivers, and found they caused more harm than the lab-made plastic beads typically used in research, stunting growth, slowing hatching, and triggering stress hormone spikes even at very low doses. Because these effects showed up at concentrations similar to what's found in real water sources, the findings suggest current safety testing may be underestimating the risks nanoplastics pose to both aquatic life and, potentially, to people who drink that water or eat seafood from it.

Oxidative damage and intestinal microbial imbalance induced by polystyrene microplastics and cadmium in zebrafish (Danio rerio)

Lipid-Rich diet protects aquatic vertebrates by reducing polystyrene nanoparticles deposition and alleviating harmful effects from exposure

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Researchers showed in zebrafish that polystyrene nanoplastics accumulate selectively in a narrow intestinal segment and alter immune and lipid metabolism gene expression, and that a lipid-rich diet significantly reduced intestinal nanoplastic deposition and partially restored normal transcriptomic profiles.