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Single-Cell Transcriptomic Analysis Reveals Heterogeneity Response Genes and Cell Communications in Zebrafish Liver to Polystyrene Nanoplastics Exposure
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Single-cell transcriptomic analysis reveals heterogeneity of the patterns of responsive genes and cell communications in liver cell populations of zebrafish exposed to polystyrene nanoplastics
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Researchers used single-cell gene analysis to examine how polystyrene nanoplastics affect different cell types in zebrafish livers. They discovered that various liver cell populations responded to nanoplastic exposure in distinctly different ways, with some cell types showing more disruption to fat metabolism and stress response genes than others. The study reveals that nanoplastic toxicity in the liver is not uniform and that certain cell populations may be more vulnerable than previously understood.
Single‐Cell Transcriptomic Analysis Reveals Hair Cell‐Specific Molecular Responses to Polystyrene Nanoplastics in a Zebrafish Embryo Model
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Researchers exposed zebrafish embryos to polystyrene nanoplastics at environmentally relevant concentrations and used single-cell RNA sequencing to identify hair cell-specific transcriptional changes in the inner ear, finding molecular-level effects without overt developmental phenotypes.
Integrated transcriptomic and metabolomic analyses to decipher the regulatory mechanisms of polystyrene nanoplastic-induced metabolic disorders in hepatocytes
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Using combined transcriptomic and metabolomic analysis, this study found that polystyrene nanoplastics disrupt lipid and amino acid metabolism in hepatocytes, identifying key regulatory genes and providing data relevant to assessing health risks from nanoplastic exposure.
Transcriptome Analysis of Soiny Mullet Larvae Challenge with Polystyrene Microplastics
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Researchers analyzed gene activity in fish larvae exposed to polystyrene microplastics and found that even short-term exposure disrupted immune-related pathways and promoted cell death, suggesting microplastics may compromise fish immune systems in ways that could have broader implications for aquatic food webs.
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