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Article ? AI-assigned paper type based on the abstract. Classification may not be perfect — flag errors using the feedback button. Tier 2 ? Original research — experimental, observational, or case-control study. Direct primary evidence. Environmental Sources Gut & Microbiome Human Health Effects Policy & Risk Sign in to save

Oral Exposure to Polystyrene Microplastics of Mice on a Normal or High-Fat Diet and Intestinal and Metabolic Outcomes

Environmental Health Perspectives 2023 115 citations ? Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count. Score: 65 ? 0–100 AI score estimating relevance to the microplastics field. Papers below 30 are filtered from public browse.
Takuro Okamura, Yuka Hasegawa, Takuro Okamura, Yuka Hasegawa, Masahide Hamaguchi, Takuro Okamura, Takuro Okamura, Yuka Hasegawa, Yuka Hasegawa, Yuka Hasegawa, Takuro Okamura, Yuka Hasegawa, Naoko Nakanishi, Yoshitaka Hashimoto, Naoko Nakanishi, Saori Majima, Masahide Hamaguchi, Saori Majima, Takafumi Senmaru, Naoko Nakanishi, Naoko Nakanishi, Michiaki Fukui Masahide Hamaguchi, Ryoichi Sasano, Emi Ushigome, Ryoichi Sasano, Hirohisa Takano, Naoko Nakanishi, Hirohisa Takano, Masahide Hamaguchi, Michiaki Fukui Mai Asano, Hirohisa Takano, Hirohisa Takano, Masahiro Yamazaki, Michiaki Fukui Hirohisa Takano, Hirohisa Takano, Ryoichi Sasano, Ryoichi Sasano, Masahide Hamaguchi, Michiaki Fukui Yuki Nakanishi, Hiroshi Seno, Hirohisa Takano, Hirohisa Takano, Michiaki Fukui

Summary

Researchers found that polystyrene microplastics caused metabolic problems like diabetes and fatty liver disease in mice, but only when combined with a high-fat diet. The high-fat diet appeared to damage the gut lining enough to allow microplastics to deposit in the intestinal wall, triggering inflammation that altered nutrient absorption. This suggests that people with poor diets may be more vulnerable to the harmful effects of microplastic exposure.

Polymers
PS
Body Systems
Immune
Models
Mouse

Our findings suggest that in this study, MP induced metabolic disturbances, such as diabetes and NAFLD, only in mice fed a high-fat diet. These findings suggest that LGS might have been triggered by HFD, causing MPs to be deposited in the intestinal mucosa, resulting in inflammation of the intestinal mucosal intrinsic layer and thereby altering nutrient absorption. These results highlight the need for reducing oral exposure to MPs through remedial environmental measures to improve metabolic disturbance under high-fat diet conditions. https://doi.org/10.1289/EHP11072.

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