0
Article Tier 2 Gut & Microbiome Sign in to save

The Effect of Polystyrene Foam on the White Mice’s Intestinal Microbiota

Mikrobiolohichnyi Zhurnal 2023 3 citations

AI summary Read the abstract

This study fed white mice polystyrene foam and analyzed changes in intestinal microbiota composition, finding that polystyrene exposure significantly altered the gut microbial community structure, adding to evidence that microplastic ingestion disrupts mammalian gut health.

Polymers
Models

Millions of tons of microplastics get into the environment, being eaten by many species of mammals and humans. One of the main types of plastic, polystyrene, and its monomer, bisphenol, have been fairly well studied in terms of their effects on metabolism, but changes in the intestinal microbiota under the influence of its addition to the diet remain insufficiently studied. The aim of this article is to describe the changes in the main components of the mice intestinal microbiota in the conditions of adding different concentrations of crushed polystyrene foam to their diet. Methods. Four groups of white laboratory mice ate crushed particles of polystyrene foam (10% of the polymer by weight of the feed, 1%, 0.1%, and the control group — without addition of plastic) as part of the compound feed for 42 days. At the end of the experiment, cultures of animal feces samples were analyzed. Results. Polystyrene foam particles in the main mice diet, especially at a higher concentration (10%), have changed the number.

More Papers Like This

Article Tier 2

Impacts of polystyrene microplastic on the gut barrier, microbiota and metabolism of mice

AI summary Read the abstract

Researchers exposed mice to polystyrene microplastics for six weeks and found that the particles accumulated in the gut, reduced protective mucus secretion, and damaged the intestinal barrier. The microplastics also significantly altered the composition of gut bacteria, decreasing beneficial species and increasing harmful ones. The study suggests that microplastic ingestion could disrupt gut health in mammals by simultaneously impairing the physical barrier and reshaping the microbiome.

Article Tier 2

Polystyrene microplastics induce gut microbiota dysbiosis and hepatic lipid metabolism disorder in mice

AI summary Read the abstract

Researchers fed mice two sizes of polystyrene microplastics for five weeks and observed significant disruption of gut bacteria and changes in liver fat metabolism. The microplastics decreased mucus production in the gut and shifted the balance of key bacterial populations at multiple taxonomic levels. The study suggests that microplastic ingestion can trigger gut microbiota imbalance in mammals, which may in turn affect metabolic health.

Article Tier 2

The impact of microplastics polystyrene on the microscopic structure of mouse intestine, tight junction genes and gut microbiota

AI summary Read the abstract

In a mouse study, polystyrene microplastics damaged the intestinal lining by reducing the height and surface area of gut structures and turning down genes responsible for keeping the gut barrier sealed. The microplastics also reduced the diversity of gut bacteria, with female mice showing more pronounced changes than males, suggesting that microplastic exposure may weaken the gut wall and shift the microbiome in ways that could affect overall health.

Article Tier 2

Long-term exposure to polystyrene microplastics promotes HFD-induced obesity in mice through exacerbating microbiota dysbiosis

AI summary Read the abstract

Researchers found that long-term polystyrene microplastic exposure worsened high-fat-diet-induced obesity in mice by exacerbating gut microbiota dysbiosis, suggesting microplastic ingestion may amplify metabolic disease risk through disruption of the gut microbiome.

Article Tier 2

Long-term exposure to polystyrene microplastics reduces macrophages and affects the microbiota–gut–brain axis in mice

AI summary Read the abstract

Mice that consumed polystyrene microplastics over an extended period showed reduced immune cells called macrophages in their colons and changes in gut bacteria that were linked to altered brain chemistry. This study provides evidence for a gut-brain connection where microplastics may affect brain function indirectly by first disrupting gut health and the immune system.

Research digests by email

When a large batch of papers lands in the Atlas, we read through it and send a short write-up of what stood out.

Email me about

Share this paper