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Low particle concentrations of nanoplastics impair the gut health of medaka

Aquatic Toxicology 2023 37 citations ? Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count. Score: 60 ? 0–100 AI score estimating relevance to the microplastics field. Papers below 30 are filtered from public browse.

Youji Wang Youji Wang Yinfeng Zhou, Yinfeng Zhou, Yinfeng Zhou, Elvis Genbo Xu, Elvis Genbo Xu, Elvis Genbo Xu, Yinfeng Zhou, Yinfeng Zhou, Yinfeng Zhou, Youji Wang Elvis Genbo Xu, Elvis Genbo Xu, Elvis Genbo Xu, Elvis Genbo Xu, Elvis Genbo Xu, Elvis Genbo Xu, Elvis Genbo Xu, Elvis Genbo Xu, Elvis Genbo Xu, Elvis Genbo Xu, Lang Gui, Lang Gui, Youji Wang Youji Wang Youji Wang Youji Wang Inna M. Sokolova, Elvis Genbo Xu, Wenbo Wei, Youji Wang Elvis Genbo Xu, Elvis Genbo Xu, Elvis Genbo Xu, Wenbo Wei, Elvis Genbo Xu, Youji Wang Youji Wang Elvis Genbo Xu, Elvis Genbo Xu, Elvis Genbo Xu, Elvis Genbo Xu, Elvis Genbo Xu, Elvis Genbo Xu, Elvis Genbo Xu, Elvis Genbo Xu, Elvis Genbo Xu, Elvis Genbo Xu, Elvis Genbo Xu, Youji Wang Youji Wang Youji Wang Inna M. Sokolova, Inna M. Sokolova, Inna M. Sokolova, Inna M. Sokolova, Inna M. Sokolova, Youji Wang Elvis Genbo Xu, Wenzhong Zhou, Elvis Genbo Xu, Elvis Genbo Xu, Elvis Genbo Xu, Elvis Genbo Xu, Elvis Genbo Xu, Youji Wang Youji Wang Youji Wang Youji Wang Youji Wang Youji Wang Youji Wang Inna M. Sokolova, Inna M. Sokolova, Inna M. Sokolova, Wenzhong Zhou, Mingyou Li, Mingyou Li, Youji Wang Youji Wang Youji Wang Youji Wang Youji Wang Elvis Genbo Xu, Youji Wang Youji Wang Youji Wang Inna M. Sokolova, Elvis Genbo Xu, Youji Wang Youji Wang Youji Wang Elvis Genbo Xu, Youji Wang Elvis Genbo Xu, Mingyou Li, Youji Wang Elvis Genbo Xu, Elvis Genbo Xu, Youji Wang Elvis Genbo Xu, Elvis Genbo Xu, Youji Wang Youji Wang Youji Wang Elvis Genbo Xu, Elvis Genbo Xu, Youji Wang Youji Wang Youji Wang Elvis Genbo Xu, Elvis Genbo Xu, Youji Wang Youji Wang Elvis Genbo Xu, Youji Wang Inna M. Sokolova, Youji Wang Youji Wang Youji Wang Youji Wang Youji Wang Youji Wang Youji Wang Inna M. Sokolova, Elvis Genbo Xu, Elvis Genbo Xu, Youji Wang Youji Wang Youji Wang Youji Wang Elvis Genbo Xu, Youji Wang Youji Wang Youji Wang Youji Wang Youji Wang Youji Wang Youji Wang Youji Wang Youji Wang Youji Wang Youji Wang Elvis Genbo Xu, Youji Wang Elvis Genbo Xu, Youji Wang Youji Wang Youji Wang Youji Wang Elvis Genbo Xu, Elvis Genbo Xu, Youji Wang Youji Wang Youji Wang Youji Wang Youji Wang

Summary

Researchers exposed Japanese medaka fish to low concentrations of nanoplastics for three months and observed significant damage to gut health, including tissue injury, impaired digestive enzymes, weakened immunity, and disrupted gut bacteria. Even at particle concentrations considered environmentally realistic, the nanoplastics caused measurable harm and increased mortality. The study suggests that long-term exposure to low levels of nanoplastics may pose greater risks to fish health than previously assumed.

Polymers

Body Systems

Digestive Immune

Models

Fish other

The environmental occurrence of nanoplastics (NPs) is now evident but their long-term impacts on organisms are unclear, limiting ecological and health risk assessment. We hypothesized that chronic exposure to low particle concentrations of NPs can result in gut-associated toxicity, and subsequently affect survival of fish. Japanese medaka Oryzias latipes were exposed to polystyrene NPs (diameter 100 nm; 0, 10, 10, and 10 items/L) for 3 months, and histopathology, digestive and antioxidant enzymes, immunity, intestinal permeability, gut microbiota, and mortality were assessed. NP exposures caused intestinal lesions, and increased intestinal permeability of the gut. The trypsin, lipase, and chymotrypsin activities were increased, but the amylase activity was decreased. Oxidative damage was reflected by the decreased superoxide dismutase and alkaline phosphatase and increased malondialdehyde, catalase, and lysozyme. The integrated biomarkers response index values of all NP-exposed medaka were significantly increased compared to the control group. Moreover, NP exposures resulted in a decrease of diversity and changed the intestinal microbiota composition. Our results provide new evidence that long-term NPs exposure impaired the health of fish at extremely low particle concentrations, suggesting the need for long-term toxicological studies resembling environmental particle concentrations when assessing the risk of NPs.

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