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Combined exposure to microplastics and pesticides with endocrine-disrupting potential: evidence of interaction, reproductive biomarkers, and tissue bioaccumulation in humans and animal models
Summary
This review study examines how tiny plastic particles (microplastics) and certain pesticides might work together to disrupt hormones and affect fertility in humans and animals. The research suggests these common pollutants may be more harmful when combined than when encountered separately, potentially impacting reproductive health. Understanding these interactions is important because people are exposed to both microplastics and pesticides daily through food, water, and the environment.
Systematic review protocol evaluating the evidence of interaction between microplastics and pesticides with endocrine-disrupting potential and their association with reproductive biomarkers and tissue bioaccumulation in humans and animal models. The project follows PRISMA-P and PRISMA-S guidelines and will be prospectively registered in PROSPERO. The review will synthesize evidence from human observational studies and experimental animal studies to assess potential additive, synergistic, or potentiating interactions between environmental contaminants within the exposome framework. All materials including the protocol, search strategies, data extraction templates, and PRISMA screening workflow will be deposited in this repository to ensure transparency and reproducibility.