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Retracted: Exogenous Hydrogen Sulfide Mitigates Oxidative Stress and Mitochondrial Damages Induced by Polystyrene Microplastics in Osteoblastic Cells of Mice
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This entry retracts a previously published study on how hydrogen sulfide affected oxidative stress caused by polystyrene microplastics in mouse bone cells. The retraction means the original conclusions about microplastic effects on bone health cannot be relied upon until the errors are addressed.
[This retracts the article DOI: 10.1155/2023/2516472.].
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Exogenous Hydrogen Sulfide Mitigates Oxidative Stress and Mitochondrial Damages Induced by Polystyrene Microplastics in Osteoblastic Cells of Mice
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Researchers found that polystyrene microplastics induced oxidative stress, mitochondrial damage, and altered gene expression in mouse bone-forming cells, while exogenous hydrogen sulfide treatment mitigated these toxic effects by modulating key signaling pathways.
Endogenous hydrogen sulfide counteracts polystyrene nanoplastics-induced mitochondrial apoptosis and excessive autophagy via regulating Nrf2 and PGC-1α signaling pathway in mouse spermatocyte-derived GC-2spd(ts) cells
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Researchers investigated how polystyrene nanoplastics damage reproductive cells in mice and whether endogenous hydrogen sulfide can provide protection. The study found that nanoplastics induced mitochondrial damage, excessive autophagy, and cell death in spermatocyte-derived cells, while hydrogen sulfide counteracted these effects by regulating oxidative stress defense pathways.
Human osteoblast-like cells exhibit anabolic attenuation and catabolic phenotypic signals after exposure to polystyrene microplastics
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Researchers exposed human bone-building cells (osteoblast-like cells) to polystyrene microplastics in a lab setting. The cells showed reduced signals linked to building new bone and increased signals linked to bone breakdown, suggesting microplastics may affect cell activity related to bone health.
Keap1-Nrf2 pathway up-regulation via hydrogen sulfide mitigates polystyrene microplastics induced-hepatotoxic effects
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Researchers investigated whether hydrogen sulfide could protect against liver damage caused by polystyrene microplastics in mice. They found that hydrogen sulfide activated the Keap1-Nrf2 antioxidant defense pathway, which reduced oxidative stress and inflammation in liver tissues exposed to microplastics. The study suggests that the Keap1-Nrf2 pathway plays a protective role against microplastic-induced hepatotoxicity and that hydrogen sulfide could be a potential therapeutic agent.
Effects of Polystyrene Microplastics on Bone-Related Protein Expression, Mineralization Capacity, and Mitochondrial Function in Osteoblastlike Cells (MG-63)
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Scientists found that tiny plastic particles (the kind now showing up in human bones) can get absorbed by bone-building cells and disrupt some of the proteins these cells need to properly regulate bone formation. The good news: in this lab study, the plastics didn't actually stop the cells from depositing calcium or affect their energy production, suggesting bone strength itself wasn't compromised, but the findings raise questions about long-term effects of microplastic buildup on bone health that scientists will need to investigate further.
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