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Single and combined effects of polyethylene microplastics and acetochlor on accumulation and intestinal toxicity of zebrafish (Danio rerio)

Environmental Pollution 2023 45 citations ? Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count. Score: 60 ? 0–100 AI score estimating relevance to the microplastics field. Papers below 30 are filtered from public browse.

Naqi Cui, Yangyang Wang, Yangyang Wang, Yangyang Wang, Huihui Cao, Yuexing Zhao, Yuexing Zhao, Yuexing Zhao, Yuexing Zhao, Naqi Cui, Yangyang Wang, Yuexing Zhao, Yuexing Zhao, Yuexing Zhao, Chaofan Ma, Chaofan Ma, Chaofan Ma, Chaofan Ma, Chaofan Ma, Chaofan Ma, Yuexing Zhao, Chaofan Ma, Wei Wei Chaofan Ma, Chaofan Ma, Chaofan Ma, Hongwu Liang, Yuexing Zhao, Huihui Cao, Huihui Cao, Chaofan Ma, Chaofan Ma, Yuexing Zhao, Yangyang Wang, Wei Wei Wei Wei Hongwu Liang, Yangyang Wang, Hongwu Liang, Chaofan Ma, Wei Wei Yuexing Zhao, Chaofan Ma, Yuexing Zhao, Wei Wei Yangyang Wang, Hongwu Liang, Chaofan Ma, Chaofan Ma, Huihui Cao, Naqi Cui, Huihui Cao, Naqi Cui, Huihui Cao, Huihui Cao, Naqi Cui, Huihui Cao, Huihui Cao, Naqi Cui, Yu Liu, Hongwu Liang, Hongwu Liang, Yuexing Zhao, Wei Wei Wei Wei Hongwu Liang, Hongwu Liang, Yu Liu, Yuexing Zhao, Hongwu Liang, Yu Liu, Yuexing Zhao, Yuexing Zhao, Yuexing Zhao, Wei Wei Huihui Cao, Wei Wei Naqi Cui, Yu Liu, Huihui Cao, Naqi Cui, Wei Wei

Summary

This study found that polyethylene microplastics significantly increased the toxicity of acetochlor, a common herbicide, in zebrafish. The microplastics boosted the accumulation of the pesticide in fish tissues and worsened intestinal damage including inflammation and disrupted gut barrier function. The findings are important because microplastics and pesticides frequently co-exist in agricultural waterways, and their combination may pose greater risks than either pollutant alone.

Polymers

Body Systems

Immune

Models

Zebrafish

The co-exposure of microplastics (MPs) and other contaminants has aroused extensive attention, but the combined impacts of MPs and pesticides remain poorly understood. Acetochlor (ACT), a widely used chloroacetamide herbicide, has raised concerns for its potential bio-adverse effects. This study evaluated the influences of polyethylene microplastics (PE-MPs) for acute toxicity, bioaccumulation, and intestinal toxicity in zebrafish to ACT. We found that PE-MPs significantly enhanced ACT acute toxicity. Also, PE-MPs increased the accumulation of ACT in zebrafish and aggravate the oxidative stress damage of ACT in intestines. Exposure to PE-MPs or/and ACT causes mild damage to the gut tissue of zebrafish and altered gut microbial composition. In terms of gene transcription, ACT exposure triggered a significant increase in inflammatory response-related gene expressions in the intestines, while some pro-inflammatory factors were found to be inhibited by PE-MPs. This study provides a new perspective on the fate of MPs in the environment and on the assessment of the combined effects of MPs and pesticides on organisms.

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