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Interplay Between Antimicrobial Resistance and Global Environmental Change
Summary
This review explores how global environmental changes, including pollution, climate change, and habitat destruction, are accelerating the spread of antimicrobial resistance. Researchers found that factors like microplastic pollution, heavy metals, and pharmaceutical waste create conditions that promote the evolution of resistant bacteria. The study suggests that addressing antimicrobial resistance requires considering it as an environmental problem, not just a medical one.
Antibiotic resistance genes predate the therapeutic uses of antibiotics. However, the current antimicrobial resistance crisis stems from our extensive use of antibiotics and the generation of environmental stressors that impose new selective pressure on microbes and drive the evolution of resistant pathogens that now threaten human health. Similar to climate change, this global threat results from human activities that change habitats and natural microbiomes, which in turn interact with human-associated ecosystems and lead to adverse impacts on human health. Human activities that alter our planet at global scales exacerbate the current resistance crisis and exemplify our central role in large-scale changes in which we are both protagonists and architects of our success but also casualties of unanticipated collateral outcomes. As cognizant participants in this ongoing planetary experiment, we are driven to understand and find strategies to curb the ongoing crises of resistance and climate change.
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