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The Complex Interplay Between Antibiotic Resistance and Pharmaceutical and Personal Care Products in the Environment

Environmental Toxicology and Chemistry 2022 44 citations ? Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count. Score: 55 ? 0–100 AI score estimating relevance to the microplastics field. Papers below 30 are filtered from public browse.

Jianhua Guo, Célia M. Manaia, Tong Zhang, Sara Rodríguez‐Mozaz William H. Gaze, Tong Zhang, Sara Rodríguez‐Mozaz Sara Rodríguez‐Mozaz Sara Rodríguez‐Mozaz Diana S. Aga, Eddie Cytryn, Jianhua Guo, Olga C. Nunes, Célia M. Manaia, William H. Gaze, Tong Zhang, Jianhua Guo, Jianhua Guo, Jianhua Guo, Jianhua Guo, Eddie Cytryn, Olga C. Nunes, William H. Gaze, Sara Rodríguez‐Mozaz Célia M. Manaia, Aimee K. Murray, Tong Zhang, Jianhua Guo, Aimee K. Murray, Célia M. Manaia, Tong Zhang, Sara Rodríguez‐Mozaz Tong Zhang, David W. Graham, Eddie Cytryn, Aimee K. Murray, Tong Zhang, Liguan Li, Jianhua Guo, Liguan Li, Aimee K. Murray, Aimee K. Murray, Jianhua Guo, Olga C. Nunes, Sara Rodríguez‐Mozaz William H. Gaze, Liguan Li, William H. Gaze, Anne Frances Clare Leonard, Célia M. Manaia, Tong Zhang, Tong Zhang, Sara Rodríguez‐Mozaz Liguan Li, Aimee K. Murray, Sara Rodríguez‐Mozaz Jianhua Guo, Aimee K. Murray, Olga C. Nunes, Sara Rodríguez‐Mozaz Sara Rodríguez‐Mozaz Sara Rodríguez‐Mozaz Edward Topp, Tong Zhang, Aimee K. Murray, Edward Topp, Célia M. Manaia, Célia M. Manaia, Sara Rodríguez‐Mozaz Eddie Cytryn, Sara Rodríguez‐Mozaz

Summary

This review explores the complex relationship between antibiotic-resistant bacteria, antibiotic resistance genes, and environmental contaminants including pharmaceuticals and personal care products. Researchers found that antibiotic resistance is often elevated in human-impacted environments, particularly where faecal waste and chemical contaminant mixtures are present. The study highlights how environmental pollution, including microplastic contamination, may contribute to the spread of antibiotic resistance through horizontal gene transfer and bacterial adaptation.

Antibiotic-resistant bacteria (ARB) and antibiotic resistance genes (ARGs) are important environmental contaminants. Nonetheless, what drives the evolution, spread, and transmission of antibiotic resistance dissemination is still poorly understood. The abundance of ARB and ARGs is often elevated in human-impacted areas, especially in environments receiving fecal wastes, or in the presence of complex mixtures of chemical contaminants, such as pharmaceuticals and personal care products. Self-replication, mutation, horizontal gene transfer, and adaptation to different environmental conditions contribute to the persistence and proliferation of ARB in habitats under strong anthropogenic influence. Our review discusses the interplay between chemical contaminants and ARB and their respective genes, specifically in reference to co-occurrence, potential biostimulation, and selective pressure effects, and gives an overview of mitigation by existing man-made and natural barriers. Evidence and strategies to improve the assessment of human health risks due to environmental antibiotic resistance are also discussed. Environ Toxicol Chem 2024;43:637-652. © 2022 SETAC.

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